Anti-influenza A H1N1 (A/Brisbane/59/2007) neuraminidase antibody [3A2] - BSA and Azide free

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Influenza A H1N1 (A/Brisbane/59/2007) neuraminidase also known as NA plays an important role mechanically in the viral life cycle. This enzyme facilitates the release of viral particles from infected host cells by cleaving sialic acid residues from glycoproteins. NA has an approximate molecular weight of 60 kDa and is expressed on the surface of influenza viral particles. Neuraminidase works closely with hemagglutinin (HA) another surface glycoprotein to ensure efficient viral budding and spread.

Biological function summary

Influenza A H1N1 neuraminidase contributes significantly to the virus's replication and transmission. As part of the viral envelope NA aids in the detachment of newly formed virions from the host cell surface. It operates as a homotetramer meaning it forms a complex with four identical subunits to execute its enzymatic activity. The neuraminidase protein is critical for overcoming the host's mucosal barriers facilitating infection of respiratory epithelial cells.

Pathways

Neuraminidase from the H1N1 influenza strain is directly involved in the viral replication cycle. The two main pathways where NA functions are the influenza virus life cycle and viral entry into host cells. In these pathways neuraminidase acts in tandem with hemagglutinin (HA) to mediate the initial host cell entry and subsequent virus spread making it a focal point for vaccine and antiviral drug development.

Associated diseases and disorders

Influenza A H1N1 neuraminidase associates closely with influenza infection a significant cause of respiratory illness globally. The NA protein also plays a role in the pathogenesis of pandemic influenza marked by rapid spread and high morbidity. In this context neuraminidase inhibitors such as oseltamivir target NA to disrupt its function and curb the infection. Additionally research connects neural cell adhesion molecule (NCAM) to influenza pathogenesis highlighting the complex interactions between viral proteins and host cell receptors that contribute to disease progression.