JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB91646

Anti-Influenza A H1N1 Neuraminidase antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal Influenza A H1N1 Neuraminidase antibody. Suitable for ELISA and reacts with Synthetic peptide - Influenza A virus (A/Georgia/20/2006(H1N1)) samples. Cited in 1 publication.
1 Images
ELISA - Anti-Influenza A H1N1 Neuraminidase antibody (AB91646)
  • ELISA

Unknown

ELISA - Anti-Influenza A H1N1 Neuraminidase antibody (AB91646)

ab91646, at 1 μg/ml, detects 2 ng of free Influenza A H1N1 Neuraminidase peptide by ELISA.
The blocking and corresponding peptides were used at 50, 10, 2 and 0 ng/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Influenza A virus (A/Georgia/20/2006(H1N1))

Applications

ELISA

applications

Specificity

ab91646 detects Neuraminidase protein from the seasonal influenza A (H1N1). It will not crossreact with peptide corresponding to the swine origin influenza (H1N1) Neuraminidase.

style
left-column

Complementary Products

Primary Antibodies

AB91645

Anti-Seasonal and Swine H1N1 Neuraminidase antibody

ELISA - Anti-Seasonal and Swine H1N1 Neuraminidase antibody (AB91645)

  • 0
  • 0
Primary Antibodies

AB197020

Anti-Neuraminidase antibody [EPR15712]

20ul selling size|RabMAb|Recombinant|KO Validated

Western blot - Anti-Neuraminidase antibody [EPR15712] (AB197020)

  • 0
  • 0
Primary Antibodies

AB313343

Anti-Influenza A Virus Nucleoprotein antibody [EPR28253-17]

20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Influenza A Virus Nucleoprotein antibody [EPR28253-17] (AB313343)

  • 5
  • 1
Primary Antibodies

AB91643

Anti-Swine H1N1 Neuraminidase antibody

ELISA - Anti-Swine H1N1 Neuraminidase antibody (AB91643)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Influenza A virus (A/Georgia/20/2006(H1N1))": { "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "" }, "Synthetic peptide - Influenza A virus (A/Georgia/20/2006(H1N1))": { "ELISA-species-checked": "testedAndGuaranteed", "ELISA-species-dilution-info": "1 µg/mL", "ELISA-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Affinity chromatography purified via peptide column.
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Influenza A H1N1 Neuraminidase often called "anti-NA" is a surface glycoprotein expressed on the Influenza A virus including strains like H1N1 Singapore. This protein has a mass of about 470 kDa. Neuraminidase cleaves sialic acid residues from glycoproteins facilitating the spread of the virus by assisting in the release of virions from infected cells. This enzymatic action is essential for the efficient propagation of the influenza virus.
Biological function summary

The function of Neuraminidase facilitates viral mobility and infectivity by preventing virion aggregation after budding from the host cell. While not part of a larger protein complex its role complements other viral surface proteins such as Hemagglutinin (HA) in mediating host cell entry and subsequent infection cycles. The interaction with Hemagglutinin is vital for maintaining viral infectivity balancing attachment to and release from host cells.

Pathways

Neuraminidase activity is embedded in processes essential to the viral life cycle such as the respiratory epithelium invasion. The protein plays a role in the neuraminidase pathway distinct from but linked to the Hemagglutinin-mediated endocytosis pathway. These pathways ensure the virus manages effective host penetration and immune evasion strategies.

The activity of Neuraminidase is directly linked to diseases such as seasonal influenza and pandemics involving H1N1 strains including Influenza A: A/Brisbane/10/07. The inhibition of Neuraminidase forms the basis for antiviral treatments like oseltamivir which aim to curb viral spread. The protein relates to disorders of immune response controlled partially by interactions with other viral proteins like Hemagglutinin which enhance or mitigate host immune activation.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

See full target information Influenza A H1N1 Neuraminidase
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Virology journal 20:183 PubMed37596622

2023

Influenza a virus regulates interferon signaling and its associated genes; MxA and STAT3 by cellular miR-141 to ensure viral replication.

Applications

Unspecified application

Species

Unspecified reactive species

Mai Alalem,Emad Dabous,Ahmed M Awad,Nedaa Alalem,Adel A Guirgis,Samir El-Masry,Hany Khalil
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com