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AB91531

Anti-Influenza A Virus Hemagglutinin H1 antibody

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(4 Publications )

Rabbit Polyclonal Hemagglutinin antibody. Suitable for ELISA, WB and reacts with Influenza A samples. Cited in 4 publications.
1 Images
Western blot - Anti-Influenza A Virus Hemagglutinin H1 antibody (AB91531)
  • WB

Unknown

Western blot - Anti-Influenza A Virus Hemagglutinin H1 antibody (AB91531)

All lanes:

Western blot - Anti-Influenza A Virus Hemagglutinin H1 antibody (ab91531) at 2 µg/mL

Lane 1:

Recombinant Influenza A Virus Hemagglutinin H1

Lane 2:

Recombinant Swine A Virus Hemagglutinin H1

Predicted band size: 63 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Influenza A

Applications

ELISA, WB

applications

Specificity

ab91531 is specific for the seasonal Influenza A Virus Hemagglutinin H1 and does not cross-react with Swine Influenza A (H1N1) Hemagglutinin.

Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Affinity chromatography purified via peptide column.
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Influenza A Virus Hemagglutinin H1 often referred to as HA or simply H1 hemagglutinin is a glycoprotein critical in the mechanical entry of influenza virus into host cells. This protein with a molecular mass of approximately 63 kDa is expressed on the surface of the Influenza A virus. It facilitates the initial attachment of the virus to the host cell by binding to sialic acid residues on the host's cell membrane. This binding prompts viral entry through endocytosis a vital step in the infectious cycle of Influenza A virus including strains like H1 influenza and H1 flu.
Biological function summary

Hemagglutinin H1 plays an important role in membrane fusion enabling the viral genome to enter the host cell cytoplasm after endocytosis. This protein functions as part of a larger complex combining with neuraminidase to facilitate successful viral replication and host infection. Neuraminidase helps in the release of new viral particles from host cells while hemagglutinin is important for initiating attachment to host cells. Therefore H1 hemagglutinin's interaction with host cells marks an essential step in the influenza viral lifecycle.

Pathways

The Influenza A H1 protein is a major player in the viral infection pathway and is intricately involved in the viral replication cycle. It interacts closely with other viral proteins predominantly neuraminidase to ensure proper viral assembly and release. The coordinated action of these proteins within the viral life cycle emphasizes hemagglutinin's role in the perpetuation and spread of the Influenza A virus aligning with broader pathways of host cell infection and immune evasion.

Hemagglutinin H1 is directly associated with influenza a contagious respiratory illness caused by influenza viruses. The protein's role in viral entry and replication makes it a target for antiviral drugs and vaccines aimed at preventing influenza infections including H1 influenza. Scientists also study the protein in understanding the body’s immune response and designing anti-flu therapies. Antibodies targeting H1 hemagglutinin can inhibit viral entry helping mitigate the symptoms and spread of flu pandemics. Additionally its structural variations contribute to the adaptability of the virus complicating vaccine development.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Target data

See full target information Influenza A Virus Hemagglutinin H1

Alternative Names

HA, Hemagglutinin, Hemagglutinin HA

Publications (4)

Recent publications for all applications. Explore the full listand refine your search

Frontiers in microbiology 11:566348 PubMed33117314

2020

Influenza A Virus Induces Autophagy by Its Hemagglutinin Binding to Cell Surface Heat Shock Protein 90AA1.

Applications

Unspecified application

Species

Unspecified reactive species

Xingbo Wang,Tuyuan Zheng,Lulu Lin,Yina Zhang,Xiran Peng,Yan Yan,Jing Lei,Jiyong Zhou,Boli Hu

Methods in molecular biology (Clifton, N.J.) 2183:331-356 PubMed32959252

2020

Attenuation Methods for Live Vaccines.

Applications

Unspecified application

Species

Unspecified reactive species

Dipasree Hajra,Akshay Datey,Dipshikha Chakravortty

Journal of virology 89:10762-73 PubMed26269186

2015

Generation of Live Attenuated Influenza Virus by Using Codon Usage Bias.

Applications

WB

Species

Unspecified reactive species

Rebecca L Y Fan,Sophie A Valkenburg,Chloe K S Wong,Olive T W Li,John M Nicholls,Raul Rabadan,J S Malik Peiris,Leo L M Poon

PloS one 8:e64555 PubMed23734205

2013

Characterization of influenza vaccine immunogenicity using influenza antigen microarrays.

Applications

Unspecified application

Species

Unspecified reactive species

Jordan V Price,Justin A Jarrell,David Furman,Nicole H Kattah,Evan Newell,Cornelia L Dekker,Mark M Davis,Paul J Utz
View all publications

Product promise

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