Mouse Monoclonal M2 antibody. Suitable for ICC and reacts with Influenza A samples. Cited in 72 publications.
Images
![Immunocytochemistry - Anti-Influenza A Virus M2 Protein antibody [14C2] (AB5416), expandable thumbnail](https://content.abcam.com/products/images/influenza-a-virus-m2-protein-antibody-14c2-ab5416--immunocytochemistry-img24147.jpg/_jcr_content/renditions/webp-475.webp "Immunocytochemistry - Anti-Influenza A Virus M2 Protein antibody [14C2] (AB5416)")
Publications
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- JACC. Basic to translational science 7:1214-12282022Targeting the Autophagy-Lysosome Pathway in a Pathophysiologically Relevant Murine Model of Reversible Heart Failure.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSarah Evans,Xiucui Ma,Xiqiang Wang,Yana Chen,Chen Zhao,Carla J Weinheimer,Attila Kovacs,Brian Finck,Abhinav Diwan,Douglas L MannPubMed 36644282
- Biophysical journal 120:5478-54902021Influenza A M2 recruits M1 to the plasma membrane: A fluorescence fluctuation microscopy study.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAnnett Petrich,Valentin Dunsing,Sara Bobone,Salvatore ChiantiaPubMed 34808098
- Cell reports 37:1098992021Subtractive CRISPR screen identifies the ATG16L1/vacuolar ATPase axis as required for non-canonical LC3 lipidation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRachel Ulferts,Elena Marcassa,Lewis Timimi,Liam Changwoo Lee,Andrew Daley,Beatriz Montaner,Suzanne Dawn Turner,Oliver Florey,John Kenneth Baillie,Rupert BealePubMed 34706226
- mBio 12:e01484212021MARCH8 Restricts Influenza A Virus Infectivity but Does Not Downregulate Viral Glycoprotein Expression at the Surface of Infected Cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFernando Villalón-Letelier,Andrew G Brooks,Sarah L Londrigan,Patrick C ReadingPubMed 34517760
- Viruses 13:2021Influenza Antigens NP and M2 Confer Cross Protection to BALB/c Mice against Lethal Challenge with H1N1, Pandemic H1N1 or H5N1 Influenza A Viruses.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNutan Mytle,Sonja Leyrer,Jon R Inglefield,Andrea M Harris,Thomas E Hickey,Jacob Minang,Hang Lu,Zhidong Ma,Hanné Andersen,Nathan D Grubaugh,Tina Guina,Mario H Skiadopoulos,Michael J LacyPubMed 34578289
- Molecular cell 81:2031-2040.e82021Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJoanne Durgan,Alf H Lystad,Katherine Sloan,Sven R Carlsson,Michael I Wilson,Elena Marcassa,Rachel Ulferts,Judith Webster,Andrea F Lopez-Clavijo,Michael J Wakelam,Rupert Beale,Anne Simonsen,David Oxley,Oliver FloreyPubMed 33909989
- Cellular microbiology 23:e133222021NS1-mediated upregulation of ZDHHC22 acyltransferase in influenza a virus infected cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMohamed Rasheed Gadalla,Eliot Morrison,Marina V Serebryakova,Xueijiao Han,Thorsten Wolff,Christian Freund,Larisa Kordyukova,Michael VeitPubMed 33629465
- Advanced science (Weinheim, Baden-Wurttemberg, Germany) 8:20045552021Trojan Horse Delivery of 4,4'-Dimethoxychalcone for Parkinsonian Neuroprotection.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWenlong Zhang,Huaqing Chen,Liuyan Ding,Junwei Gong,Mengran Zhang,Wenyuan Guo,Pingyi Xu,Shiying Li,Yunlong ZhangPubMed 33977069
- Vaccines 9:2021-Based Cell-Free Protein Synthesis for Iterative Design of Tandem-Core Virus-Like Particles.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNoelle Colant,Beatrice Melinek,Stefanie Frank,William Rosenberg,Daniel G BracewellPubMed 33669126
- PLoS pathogens 17:e10093402021Mitochondrial morphodynamics alteration induced by influenza virus infection as a new antiviral strategy.Applications:Unspecified applicationReactive species:Unspecified reactive speciesIrene Pila-Castellanos,Diana Molino,Joe McKellar,Laetitia Lines,Juliane Da Graca,Marine Tauziet,Laurent Chanteloup,Ivan Mikaelian,Laurène Meyniel-Schicklin,Patrice Codogno,Jacky Vonderscher,Cédric Delevoye,Olivier Moncorgé,Eric Meldrum,Caroline Goujon,Etienne Morel,Benoit de ChasseyPubMed 33596274
Key facts
- Isotype
- IgG1
- Host species
- Mouse
- Storage buffer
Preservative: 0.05% Sodium azide
Constituents: 99% PBS, 0.1% BSA- Form
- Liquid
- Clonality
- Monoclonal
Reactivity data
Select an application| ICC | |
|---|---|
| Influenza A | Tested |
ICC
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Influenza A | Dilution info 1 µg/mL | Notes - |
Alternative names
Influenza A virus matrix protein M2, Matrix protein 2, Membrane ion channel M2, Membrane protein M2, Proton channel protein M2
Recommended products
Mouse Monoclonal M2 antibody. Suitable for ICC and reacts with Influenza A samples. Cited in 72 publications.
Key facts
- Isotype
- IgG1
- Host species
- Mouse
- Storage buffer
Preservative: 0.05% Sodium azide
Constituents: 99% PBS, 0.1% BSA- Form
- Liquid
- Clonality
- Monoclonal
- Clone number
- 14C2
- Purification technique
- Affinity purification Protein G
- Epitope
- Detects the N-terminal of the Influenza A Virus M2 Protein.
- Light chain type
- kappa
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The Influenza A Virus M2 Protein also known as M2 ion channel or matrix protein 2 plays an essential role in the viral life cycle. This protein has a mass of approximately 97 amino acids and is expressed on the envelope of the Influenza A virus. It functions as a proton-selective channel facilitating the acidification of the viral interior after the virus enters the host cell. This acidification process is important for the uncoating of the viral genome allowing subsequent replication of the virus in host cells.
- Biological function summary
The M2 protein from Influenza A virus participates in virus assembly budding and release. The protein operates as a tetramer creating a channel across the viral membrane. This channel is essential for the correct function and structure of the virus playing an important role in membrane fusion and release of the viral particles. It often works in conjunction with another matrix protein M1 which assists in stabilizing the integrity of the viral structure.
- Pathways
The M2 Influenza protein is integral to the viral replication and assembly pathway. It aligns with the function of the viral ribonucleoprotein complex and is significant in the viral entry and exit pathways. Additionally the connection to the M1 matrix protein highlights its coordinated role in facilitating the assembly and release of new virions from the infected cells emphasizing its necessity in productive viral replication.
- Associated diseases and disorders
The Influenza A virus M2 protein is directly related to the pathogenesis of seasonal influenza. Antiviral drugs like amantadine and rimantadine target this ion channel to disrupt viral replication. Resistance mutations in the M2 protein can influence the efficacy of these drugs impacting treatment outcomes. There is also a link with immune system responses where M2 interactions with other viral proteins can modulate host immune evasion mechanisms.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
![Immunocytochemistry - Anti-Influenza A Virus M2 Protein antibody [14C2] (ab5416), expandable thumbnail](https://content.abcam.com/products/images/influenza-a-virus-m2-protein-antibody-14c2-ab5416--immunocytochemistry-img24147.jpg "Immunocytochemistry - Anti-Influenza A Virus M2 Protein antibody [14C2] (ab5416)")
Immunocytochemistry - Anti-Influenza A Virus M2 Protein antibody [14C2] (ab5416)
Immunofluorescence staining of infected dog MDCK cells using ab5416.
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