Anti-Influenza B Virus Neuraminidase antibody [HL1476] - BSA and Azide free

Supplementary info

Activity summary

Influenza B Virus Neuraminidase also known as Influenza B NA is an enzyme important for the viral life cycle. This protein has an approximate molecular mass of 60 kDa and is expressed on the surface of the Influenza B virus. Neuraminidase facilitates the release of virions from infected cells by cleaving sialic acid residues aiding viral spread. It acts as a tetramer forming a homotetrameric structure which is essential for its enzymatic activity.

Biological function summary

The neuraminidase functions as part of the viral replication process. By cleaving sialic acid it prevents viral aggregation at the host cell surface ensuring efficient viral dissemination. This activity complements hemagglutinin another glycoprotein on the viral surface which binds to sialic acid on host cells to initiate infection. Together these proteins orchestrate the infection process marking the structural and functional complexity of the virus.

Pathways

Neuraminidase plays an integral role in the viral lifecycle pathway of the Influenza B virus. It closely interacts with the HA/NA balance where hemagglutinin (HA) binding necessitates subsequent neuraminidase activity to liberate progeny virions. This interaction is critical for maintaining the balance of viral attachment and release during infection influencing the overall efficiency of viral propagation.

Associated diseases and disorders

The neuraminidase of the Influenza B virus is a significant target in antiviral drug design particularly in relation to influenza infections. Drugs like oseltamivir target neuraminidase to block its activity reducing viral spread and severity of infection. Furthermore the activity of neuraminidase is associated with resistance mutations influencing the effectiveness of antiviral treatment therefore posing significant challenges in combating influenza outbreaks.