Rabbit Polyclonal Inhibin beta A antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 9 publications. Immunogen corresponding to Synthetic Peptide within Human Inhibin beta A chain aa 350 to C-terminus.
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Publications
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- Cells 12:2023Tubule-Derived Follistatin Is Increased in the Urine of Rats with Renal Ischemia and Reflects the Severity of Acute Tubular Damage.Applications:Unspecified applicationReactive species:Unspecified reactive speciesIzumi Nagayama,Kaori Takayanagi,Hajime Hasegawa,Akito MaeshimaPubMed 36899937
- Disease markers 2021:42517632021Development and Verification of an Immune-Based Gene Signature for Risk Stratification and Immunotherapeutic Efficacy Assessment in Gastric Cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFeng Qiu,Yumei Zhu,Yafeng Shi,Jingjing Ji,Yingchao JinPubMed 34804261
- Molecular medicine reports 24:2021Inhibin βA is an independent prognostic factor that promotes invasion via Hippo signaling in non‑small cell lung cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYijun Zhang,Shumei Yan,Yan Li,Jiangbo Zhang,Yuan Luo,Pengcheng Li,Yuanzhong Yang,Yong Li,Yuhua Huang,Enhua WangPubMed 34505633
- Frontiers in immunology 11:6139752021GM-CSF Expression and Macrophage Polarization in Joints of Undifferentiated Arthritis Patients Evolving to Rheumatoid Arthritis or Psoriatic Arthritis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSara Fuentelsaz-Romero,Andrea Cuervo,Lizbeth Estrada-Capetillo,Raquel Celis,Raquel García-Campos,Julio Ramírez,Sergi Sastre,Rafael Samaniego,Amaya Puig-Kröger,Juan D CañetePubMed 33679701
- PloS one 14:e02237032019Urinary Activin A is a novel biomarker reflecting renal inflammation and tubular damage in ANCA-associated vasculitis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYoshinori Takei et. al.PubMed 31613925
- Bioscience reports 39:2019Activin A: a novel urinary biomarker of renal impairment in multiple myeloma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHirono Iriuchishima et. al.PubMed 31072919
- Circulation research 122:1347-13532018Regulates Igf2bp2 Translation in Cardiomyocytes.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMohammed Rabiul Hosen et. al.PubMed 29483092
- Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 20:757-692012Identification of biomarkers in sequential biopsies of patients with chronic wounds receiving simultaneous acute wounds: a genetic, histological, and noninvasive imaging study.Applications:Unspecified applicationReactive species:Unspecified reactive speciesBarbara Shih,Muhammad J Sultan,Iskander H Chaudhry,Kian T Tan,Kavan S Johal,Arshiya Marstan,Melody Tsai,Mohammed Baguneid,Ardeshir BayatPubMed 22985042
- Endocrinology 152:3779-902011IL-1beta stimulates activin betaA mRNA expression in human skin fibroblasts through the MAPK pathways, the nuclear factor-kappaB pathway, and prostaglandin E2.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.025% Proclin 300
Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human Inhibin beta A chain aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link P08476
Reactivity data
Select an application| WB | ICC/IF | |
|---|---|---|
| Human | Tested | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100.00000 - 1/200.00000 | Notes - |
Associated Products
Select an associated product type
2 products for Alternative Product
Target data
Function
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Alternative names
Inhibin beta A chain, Activin beta-A chain, Erythroid differentiation protein, EDF, INHBA
Recommended products
Rabbit Polyclonal Inhibin beta A antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 9 publications. Immunogen corresponding to Synthetic Peptide within Human Inhibin beta A chain aa 350 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.025% Proclin 300
Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human Inhibin beta A chain aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link P08476
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Inhibin beta A also known as activin beta A chain and inhibin A is a protein with a significant role in the regulation of diverse physiological processes. This protein has a molecular mass of approximately 45 kDa and originates primarily from gonadal tissues but also from the placenta pituitary gland and other tissues. Inhibin beta A consists of several subunits that can dimerize to form both activins and inhibins depending on the pairing with other subunits like the alpha chain.
- Biological function summary
Activin beta A chain plays an important role in the modulation of follicle-stimulating hormone (FSH) regulation cellular growth and differentiation. It often functions as part of a complex with activin and inhibin proteins influencing reproductive hormone levels and participating in tissue repair and inflammation processes. Inhibin beta A forms activin A when paired with another inhibin beta A subunit or inhibin A when paired with an inhibin alpha subunit therefore contributing to the modulation of FSH-releasing protein activity.
- Pathways
Activin and inhibin proteins participate in the regulation of the TGF-beta signaling pathway which is essential for reproductive and developmental processes. In this context inhibin beta A interacts functionally with proteins such as follistatin and FSH-releasing protein which modulate pathways that influence follicle maturation and hormone secretion. The protein's role in these pathways highlights its importance in orchestrating hormonal responses and facilitating proper cellular communication within the endocrine system.
- Associated diseases and disorders
Inhibin beta A becomes relevant in the context of reproductive health and oncology. Changes in its expression can associate with disorders like polycystic ovary syndrome (PCOS) and certain cancers particularly ovarian cancer where it may alter hormonal regulation and tumor progression. Related proteins such as inhibin B and follistatin also play roles in these conditions further complicating the pathways and the potential development of therapeutic interventions that target inhibin beta A and its network of interactions.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Western blot - Anti-Inhibin beta A antibody (ab97705)
10% SDS-PAGE.
All lanes: Western blot - Anti-Inhibin beta A antibody (ab97705) at 1/1000 dilution
Lane 1: H1299 whole cell lysate at 30 µg
Lane 2: HeLa S3 whole cell lysate at 30 µg
Lane 3: HepG2 whole cell lysate at 30 µg
Predicted band size: 47 kDa
Immunocytochemistry/ Immunofluorescence - Anti-Inhibin beta A antibody (ab97705)
ab97705, at 1/200 dilution, staining Inhibin beta A in paraformaldehyde-fixed HeLa cells by Immunofluorescence. Lower image is merged with DNA probe.
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