Anti-Inhibin beta B antibody [EPR2787(2)]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Inhibin beta B also known as INHBB protein is a subunit of the inhibin protein family. This protein has a molecular mass near 45 kDa. Inhibin beta B is expressed in the pituitary gland reproductive organs such as the ovary and testis and also can be found in the placenta. The subunit can dimerize with other members of the inhibin family to form dimers like activin AB which play a role in diverse physiological processes.

Biological function summary

The inhibin protein and its subunits such as inhibin beta B participate in the regulation of reproductive functions. It is part of the activin-inhibin complex influencing the secretion of follicle-stimulating hormone (FSH). Inhibin beta B can bind with another inhibin beta chain or with inhibin alpha to form different dimers which exert distinct biological effects through their interaction with specific receptors on target cells.

Pathways

Inhibin beta B is an essential component in the TGF-beta signaling pathway. It contributes to the regulation of cell growth and differentiation. Inhibin beta B interacts closely with proteins like follistatin which binds to activins and modulates their activities. The participation of inhibin beta B in this signaling pathway holds significant implications for its function in both reproductive and systemic processes.

Associated diseases and disorders

Inhibin beta B shows a connection to conditions like polycystic ovary syndrome (PCOS) and certain reproductive tumors. The imbalanced expression of this protein can contribute to the pathophysiology of these disorders. Alongside proteins such as inhibin alpha inhibin beta B's altered signaling activity in the TGF-beta pathway may influence disease progression making it a target of interest for therapeutic interventions.