AB128944

Anti-Inhibin beta B antibody [EPR2788(2)]

RabMAb
Recombinant
What is this?

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(2 Publications)

Rabbit Recombinant Monoclonal Inhibin beta B antibody. Suitable for WB and reacts with Mouse, Human, Rat samples. Cited in 2 publications.

View Alternative Names

Inhibin beta B chain, Activin beta-B chain, INHBB

3 Images

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Western blot - Anti-Inhibin beta B antibody [EPR2788(2)] (AB128944)

All lanes:

Western blot - Anti-Inhibin beta B antibody [EPR2788(2)] (ab128944) at 1/1000 dilution

Lane 1:

Mouse brain lysate at 10 µg

Lane 2:

Rat brain lysate at 10 µg

Secondary

All lanes:

HRP labelled goat anti-rabbit at 1/2000 dilution

Predicted band size: 45 kDa

Observed band size: 52 kDa

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Western blot - Anti-Inhibin beta B antibody [EPR2788(2)] (AB128944)

All lanes:

Western blot - Anti-Inhibin beta B antibody [EPR2788(2)] (ab128944) at 1/1000 dilution

All lanes:

Human Inhibin beta B recombinant protein (mature form: 17 kDa) (10 ng)

Secondary

All lanes:

HRP labelled goat anti-rabbit at 1/2000 dilution

Predicted band size: 45 kDa

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OI-RD Scanning - Anti-Inhibin beta B antibody [EPR2788(2)] (AB128944)

OI-RD Scanning

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OI-RD Scanning - Anti-Inhibin beta B antibody [EPR2788(2)] (AB128944)

We have systematically measured KD (the equilibrium dissociation constant between the antibody and its antigen), of more than 840 recombinant antibodies to assess not only their individual KD values but also to see the average affinity of antibody. Based on the comparison with published literature values for mouse monoclonal antibodies, Recombinant antibodies appear to be on average 1-2 order of magnitude higher affinity.

Carrier free

Anti-Inhibin beta B antibody [EPR2788(2)] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR2788(2)

Isotype

IgG

Carrier free

Reacts with

Mouse, Rat, Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Product details

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Stable for 12 months at -20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Inhibin beta B also known as INHBB protein is a subunit of the inhibin protein family. This protein has a molecular mass near 45 kDa. Inhibin beta B is expressed in the pituitary gland reproductive organs such as the ovary and testis and also can be found in the placenta. The subunit can dimerize with other members of the inhibin family to form dimers like activin AB which play a role in diverse physiological processes.

Biological function summary

The inhibin protein and its subunits such as inhibin beta B participate in the regulation of reproductive functions. It is part of the activin-inhibin complex influencing the secretion of follicle-stimulating hormone (FSH). Inhibin beta B can bind with another inhibin beta chain or with inhibin alpha to form different dimers which exert distinct biological effects through their interaction with specific receptors on target cells.

Pathways

Inhibin beta B is an essential component in the TGF-beta signaling pathway. It contributes to the regulation of cell growth and differentiation. Inhibin beta B interacts closely with proteins like follistatin which binds to activins and modulates their activities. The participation of inhibin beta B in this signaling pathway holds significant implications for its function in both reproductive and systemic processes.

Inhibin beta B shows a connection to conditions like polycystic ovary syndrome (PCOS) and certain reproductive tumors. The imbalanced expression of this protein can contribute to the pathophysiology of these disorders. Alongside proteins such as inhibin alpha inhibin beta B's altered signaling activity in the TGF-beta pathway may influence disease progression making it a target of interest for therapeutic interventions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

See full target information INHBB

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cancers 15: PubMed36612143

2022

Activin B and Activin C Have Opposing Effects on Prostate Cancer Progression and Cell Growth.

Applications

Unspecified application

Species

Unspecified reactive species

Karen L Reader,Simon John-McHaffie,Sylvia Zellhuber-McMillan,Tim Jowett,David G Mottershead,Heather E Cunliffe,Elspeth J Gold

Journal of the American Heart Association 7:e009179 PubMed30371330

2018

Regulator of G Protein Signaling 6 Facilities Cardiac Hypertrophy by Activating Apoptosis Signal-Regulating Kinase 1-P38/c-JUN N-Terminal Kinase 1/2 Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Zhijun Huang,Jingxian Shu,Weihong Jiang,Mengqing Jiang,Yao Lu,Haijiang Dai,Nana Xu,Hong Yuan,Jingjing Cai

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Inhibin beta B antibody [EPR2788(2)]

Western blot - Anti-Inhibin beta B antibody [EPR2788(2)] (AB128944)

Western blot - Anti-Inhibin beta B antibody [EPR2788(2)] (AB128944)

OI-RD Scanning - Anti-Inhibin beta B antibody [EPR2788(2)] (AB128944)

Related conjugates and formulations (1)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

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