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Rabbit Recombinant Monoclonal Inhibin beta B antibody. Carrier free. Suitable for WB and reacts with Mouse, Rat, Human samples.

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Images

Western blot - Anti-Inhibin beta B antibody [EPR2788(2)] - BSA and Azide free (AB226845), expandable thumbnail
  • OI-RD Scanning - Anti-Inhibin beta B antibody [EPR2788(2)] - BSA and Azide free (AB226845), expandable thumbnail

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.2 - 7.4
Constituents: PBS

Form

Liquid

Clonality

Monoclonal

Immunogen

  • The exact immunogen used to generate this antibody is proprietary information.

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WB
Human
Tested
Mouse
Tested
Rat
Tested

Tested
Tested

Species

Mouse, Rat, Human

Dilution info

-

Notes

-

Associated Products

Select an associated product type

2 products for Alternative Product

Target data

Function

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Alternative names

Inhibin beta B chain, Activin beta-B chain, INHBB

Recommended products

Rabbit Recombinant Monoclonal Inhibin beta B antibody. Carrier free. Suitable for WB and reacts with Mouse, Rat, Human samples.

Alternative names

Inhibin beta B chain, Activin beta-B chain, INHBB

Key facts

Isotype

IgG

Form

Liquid

Clonality

Monoclonal

Immunogen
  • The exact immunogen used to generate this antibody is proprietary information.
Carrier free

Yes

Clone number

EPR2788(2)

Purification technique

Affinity purification Protein A

Dissociation constant

2.78 x 10-11 M

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate long-term storage conditions

+4°C

Storage information

Do Not Freeze

Notes

ab226845 is the carrier-free version of Anti-Inhibin beta B antibody [EPR2788(2)] ab128944.

Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. The carrier-free buffer and high concentration allow for increased conjugation efficiency.

This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

This product is compatible with the Maxpar® Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar® is a trademark of Fluidigm Canada Inc.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Inhibin beta B also known as INHBB protein is a subunit of the inhibin protein family. This protein has a molecular mass near 45 kDa. Inhibin beta B is expressed in the pituitary gland reproductive organs such as the ovary and testis and also can be found in the placenta. The subunit can dimerize with other members of the inhibin family to form dimers like activin AB which play a role in diverse physiological processes.

Biological function summary

The inhibin protein and its subunits such as inhibin beta B participate in the regulation of reproductive functions. It is part of the activin-inhibin complex influencing the secretion of follicle-stimulating hormone (FSH). Inhibin beta B can bind with another inhibin beta chain or with inhibin alpha to form different dimers which exert distinct biological effects through their interaction with specific receptors on target cells.

Pathways

Inhibin beta B is an essential component in the TGF-beta signaling pathway. It contributes to the regulation of cell growth and differentiation. Inhibin beta B interacts closely with proteins like follistatin which binds to activins and modulates their activities. The participation of inhibin beta B in this signaling pathway holds significant implications for its function in both reproductive and systemic processes.

Associated diseases and disorders

Inhibin beta B shows a connection to conditions like polycystic ovary syndrome (PCOS) and certain reproductive tumors. The imbalanced expression of this protein can contribute to the pathophysiology of these disorders. Alongside proteins such as inhibin alpha inhibin beta B's altered signaling activity in the TGF-beta pathway may influence disease progression making it a target of interest for therapeutic interventions.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

2 product images

  • Western blot - Anti-Inhibin beta B antibody [EPR2788(2)] - BSA and Azide free (ab226845), expandable thumbnail

    Western blot - Anti-Inhibin beta B antibody [EPR2788(2)] - BSA and Azide free (ab226845)

    This data was developed using the same antibody clone in a different buffer formulation containing PBS, BSA, glycerol, and sodium azide (Anti-Inhibin beta B antibody [EPR2788(2)] ab128944).

    All lanes: Western blot - Anti-Inhibin beta B antibody [EPR2788(2)] (Anti-Inhibin beta B antibody [EPR2788(2)] ab128944) at 1/1000 dilution

    All lanes: Human Inhibin beta B recombinant protein (mature form: 17 kDa) (10 ng)

    Secondary

    All lanes: HRP labelled goat anti-rabbit at 1/2000 dilution

    Predicted band size: 45 kDa

  • OI-RD Scanning - Anti-Inhibin beta B antibody [EPR2788(2)] - BSA and Azide free (ab226845), expandable thumbnail

    OI-RD Scanning - Anti-Inhibin beta B antibody [EPR2788(2)] - BSA and Azide free (ab226845)

    We have systematically measured KD (the equilibrium dissociation constant between the antibody and its antigen), of more than 840 recombinant antibodies to assess not only their individual KD values but also to see the average affinity of antibody.
    Based on the comparison with published literature values for mouse monoclonal antibodies, Recombinant antibodies appear to be on average 1-2 order of magnitude higher affinity.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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