Anti-Inhibin beta E chain antibody ab103167 is a rabbit polyclonal antibody that is used in Inhibin beta E chain western blotting. Suitable for human and mouse samples.
Images
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.4
Constituents: 100% PBS- Form
Liquid
- Clonality
Polyclonal
Immunogen
- Recombinant Full Length Protein corresponding to Human INHBE. Database link P58166
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
| Mouse | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/500.00000 - 1/1000.00000 | Notes - |
Species Human | Dilution info 1/500.00000 - 1/1000.00000 | Notes - |
Associated Products
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Target data
Function
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Alternative names
Inhibin beta E chain, Activin beta-E chain, INHBE
Recommended products
Anti-Inhibin beta E chain antibody ab103167 is a rabbit polyclonal antibody that is used in Inhibin beta E chain western blotting. Suitable for human and mouse samples.
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.4
Constituents: 100% PBS- Form
Liquid
- Clonality
Polyclonal
- Immunogen
- Recombinant Full Length Protein corresponding to Human INHBE. Database link P58166
- Carrier free
Yes
- Purification technique
Affinity purification Protein A
- Concentration
Storage
- Shipped at conditions
Blue Ice
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The Inhibin beta E chain also known as 'INHBE' is a protein with multiple roles in the human body weighing about 42 kDa. It is a member of the transforming growth factor-beta (TGF-β) superfamily. The protein can be expressed in many tissues including the liver and placenta. INHBE is associated with other proteins to form different complexes affecting various biological processes.
- Biological function summary
The Inhibin beta E chain participates in the regulation of reproductive hormone activity. It forms either homodimers or heterodimers combining with other inhibin and activin molecules. The dimerization with alpha chains forms inhibins while pairing with other beta subunits forms activins. These complexes then modulate signaling pathways that adjust hormonal secretion particularly in the pituitary and gonadal tissues.
- Pathways
Inhibin beta E chain plays a significant role in the activin signaling pathway. This pathway affects the regulation of FSH (follicle-stimulating hormone) secretion which is important for reproductive processes. INHBE relates to proteins such as follistatin and activin A within these pathways influencing activities flowing from ligand-receptor interactions to transcriptional regulation.
- Associated diseases and disorders
Inhibin beta E chain has been linked to certain reproductive and metabolic disorders. For instance abnormal expression or dysfunction of INHBE may relate to polycystic ovary syndrome (PCOS) affecting women’s fertility. Liver diseases such as non-alcoholic fatty liver disease (NAFLD) also show associations with INHBE levels. In these contexts INHBE interacts with various TGF-β family proteins contributing to either disease progression or regulation.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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In the unlikely event of one of our products not working as expected, you are covered by our product promise.
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3 product images
Western blot - Anti-Inhibin beta E chain antibody (ab103167)
All lanes: Western blot - Anti-Inhibin beta E chain antibody (ab103167) at 1/500 dilution
All lanes: Human liver tissue lysate at 50 µg
Predicted band size: 118 kDa, 39 kDa, 49 kDa, 67 kDa
Western blot - Anti-Inhibin beta E chain antibody (ab103167)
All lanes: Western blot - Anti-Inhibin beta E chain antibody (ab103167) at 1/500 dilution
All lanes: Mouse liver tissue lysate at 50 µg
Predicted band size: 39 kDa
Western blot - Anti-Inhibin beta E chain antibody (ab103167)
All lanes: Western blot - Anti-Inhibin beta E chain antibody (ab103167) at 1/500 dilution
Lane 1: INHBE transfected 293T cell line lysate at 25 µg
Lane 2: Non-transfected 293T cell line lysate at 25 µg
Predicted band size: 23 kDa, 29 kDa, 31 kDa, 32 kDa, 33 kDa, 39 kDa, 41 kDa, 43 kDa, 48 kDa, 59 kDa, 60 kDa, 69 kDa, 96 kDa
Observed band size: 35 kDa, 60 kDa
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