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AB254687

Anti-Inhibin beta E chain antibody

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(2 Publications)

Rabbit Polyclonal Inhibin beta E chain antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human INHBE aa 150-300.

View Alternative Names

Inhibin beta E chain, Activin beta-E chain, INHBE

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-Inhibin beta E chain antibody (AB254687)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Inhibin beta E chain antibody (AB254687)

PFA fixed, Triton X-100 permeabilized Hep G2 (Human liver hepatocellular carcinoma cell line) cells labeling Inhibin beta E chain using ab254687 at 4µg/ml (green) in ICC/IF.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Inhibin beta E chain antibody (AB254687)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Inhibin beta E chain antibody (AB254687)

Paraffin-embedded human liver tissue stained for Inhibin beta E chain using ab254687 at 1/200 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Inhibin beta E chain antibody (AB254687)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Inhibin beta E chain antibody (AB254687)

Paraffin-embedded human kidney tissue stained for Inhibin beta E chain using ab254687 at 1/200 dilution in immunohistochemical analysis. Low expression, as expected.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human INHBE aa 150-300. The exact immunogen used to generate this antibody is proprietary information.

P58166

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Inhibin beta E chain also known as 'INHBE' is a protein with multiple roles in the human body weighing about 42 kDa. It is a member of the transforming growth factor-beta (TGF-β) superfamily. The protein can be expressed in many tissues including the liver and placenta. INHBE is associated with other proteins to form different complexes affecting various biological processes.
Biological function summary

The Inhibin beta E chain participates in the regulation of reproductive hormone activity. It forms either homodimers or heterodimers combining with other inhibin and activin molecules. The dimerization with alpha chains forms inhibins while pairing with other beta subunits forms activins. These complexes then modulate signaling pathways that adjust hormonal secretion particularly in the pituitary and gonadal tissues.

Pathways

Inhibin beta E chain plays a significant role in the activin signaling pathway. This pathway affects the regulation of FSH (follicle-stimulating hormone) secretion which is important for reproductive processes. INHBE relates to proteins such as follistatin and activin A within these pathways influencing activities flowing from ligand-receptor interactions to transcriptional regulation.

Inhibin beta E chain has been linked to certain reproductive and metabolic disorders. For instance abnormal expression or dysfunction of INHBE may relate to polycystic ovary syndrome (PCOS) affecting women’s fertility. Liver diseases such as non-alcoholic fatty liver disease (NAFLD) also show associations with INHBE levels. In these contexts INHBE interacts with various TGF-β family proteins contributing to either disease progression or regulation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.. Activin E is a homodimer of INHBE secreted by the liver that plays a crucial role in regulating metabolic homeostasis particularly in lipid metabolism and energy homeostasis. Plays a central role in the regulation of adipose tissue lipolysis by preventing the influx of fatty acids from adipose tissue into the liver. Mechanistically, signals via ACVR1C to activate SMAD2/3 signaling, suppressing PPARG target genes in adipose tissue, thereby reducing liver lipid content and improving glycemic control (PubMed : 38533769). Induces beige adipocyte formation and thermogenesis in response to cold exposure (By similarity).
See full target information INHBE
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 25: PubMed38542224

2024

Mitochondrial Ribosomal Protein MRPS15 Is a Component of Cytosolic Ribosomes and Regulates Translation in Stressed Cardiomyocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Florian David,Emilie Roussel,Carine Froment,Tangra Draia-Nicolau,Françoise Pujol,Odile Burlet-Schiltz,Anthony K Henras,Eric Lacazette,Florent Morfoisse,Florence Tatin,Jean-Jacques Diaz,Frédéric Catez,Barbara Garmy-Susini,Anne-Catherine Prats

Therapeutic advances in medical oncology 13:17588359211006949 PubMed33889215

2021

Development and external validation of a composite immune-clinical prognostic model associated with EGFR mutation in East-Asian patients with lung adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Chengming Liu,Sufei Zheng,Sihui Wang,Xinfeng Wang,Xiaoli Feng,Nan Sun,Jie He
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Product promise

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