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AB151046

Anti-INO80C antibody

4

(1 Review)

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(1 Publication)

Rabbit Polyclonal INO80C antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human INO80C.

View Alternative Names

C18orf37, INO80C, INO80 complex subunit C, IES6 homolog, hIes6

5 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-INO80C antibody (AB151046)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-INO80C antibody (AB151046)

Immunohistochemistry analysis of human skeletal muscle tissue labeling INO80C of myocytes with ab151046 at a 1/200 dilution.

Performed heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-INO80C antibody (AB151046)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-INO80C antibody (AB151046)

Immunohistochemistry analysis of human kidney tissue labeling INO80C of tubules cells with ab151046 at 1/200 dilution.

Performed heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunocytochemistry/ Immunofluorescence - Anti-INO80C antibody (AB151046)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-INO80C antibody (AB151046)

Immunofluorescence analysis of U-2 OS (human bone osteosarcoma epithelial cell line) whole cells labeling INO80C at the nucleoli fibrilar center with ab151046 at 2 μg/ml.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-INO80C antibody (AB151046)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-INO80C antibody (AB151046)

Immunohistochemistry analysis of human testis tissue labeling INO80C at the nuclues of seminiferous ducts with ab151046 at a 1/200 dilution.

Performed heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunocytochemistry/ Immunofluorescence - Anti-INO80C antibody (AB151046)
  • ICC/IF

AbReview37564****

Immunocytochemistry/ Immunofluorescence - Anti-INO80C antibody (AB151046)

ab151046 staining INO80C in Mouse paraffin-fixed tissue sections by ICC/IF (Immunocytochemistry/immunofluorescence). Cells were fixed with paraformaldehyde. Samples were incubated with primary antibody (1/100 in Goat serum) for 24 hours at 4°C. An Alexa Fluor® 555-conjugated anti-rabbit IgG polyclonal (1/125) was used as the secondary antibody. Red - INO80C, Blue (DAPI) - nuclei.

This image is courtesy of an anonymous Abreview

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human INO80C. The exact immunogen used to generate this antibody is proprietary information.

Q6PI98

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "0.04-4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

INO80C also known as Ino80 complex subunit C is a component of the INO80 chromatin remodeling complex. It plays a critical role in modifying chromatin structure. INO80C with a molecular mass of approximately 81 kDa is widely expressed in human tissues. This protein contributes to the dynamic regulation of chromatin by altering the position and composition of nucleosomes which assists in regulating access to DNA.
Biological function summary

INO80C is involved in maintaining genome stability and is an important player in DNA repair processes. It forms part of the multi-subunit INO80 complex a member of the ATP-dependent chromatin-remodeling family. This complex facilitates the repair of DNA double-strand breaks by promoting homologous recombination a precise DNA repair mechanism. INO80C's role in the complex also supports DNA replication and transcription regulation indicating its importance in cell cycle progression.

Pathways

INO80C is involved in the DNA damage response and repair pathway as well as the transcriptional regulation pathway. Within these pathways INO80C interacts with other proteins such as RAD51 and BRCA1 to assist in the repair of double-strand breaks. It also influences the transcriptional activities by affecting RNA polymerase II-mediated transcription initiation. The interactions with these proteins help integrate INO80C's function into broader cellular responses to DNA damage and gene expression.

INO80C's function connects to cancer and aging-related disorders. Its role in DNA repair and genome stability suggests that abnormalities in INO80C could contribute to genomic instability and tumorigenesis. Furthermore INO80C links to BRCA1 a protein associated with breast and ovarian cancer susceptibility. Dysregulation of INO80C and related pathways might also contribute to premature aging by affecting cellular repair processes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
See full target information INO80C
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Redox report : communications in free radical research 29:2354625 PubMed38794801

2024

TOM5 regulates the mitochondrial membrane potential of alveolar epithelial cells in organizing pneumonia.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Qian,Xiao Li,Xinyu Li,Xijie Zhang,Qi Yuan,Zhengxia Wang,Minghun Zhang,Mao Huang,Ningfei Ji
View all publications
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Product promise

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