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AB118418

Anti-INPP5A antibody

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(2 Publications)

Rabbit Polyclonal INPP5A antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human INPP5A aa 100-350.

View Alternative Names

5PTASE, INPP5A, Inositol polyphosphate-5-phosphatase A, 43 kDa inositol polyphosphate 5-phosphatase, 5PTase

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-INPP5A antibody (AB118418)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-INPP5A antibody (AB118418)

ab118418, at 1/100 dilution, staining INPPA5 in paraffin-embedded Human fetal spleen tissue by Immunohistochemistry.

Western blot - Anti-INPP5A antibody (AB118418)
  • WB

Unknown

Western blot - Anti-INPP5A antibody (AB118418)

All lanes:

Western blot - Anti-INPP5A antibody (ab118418) at 1/500 dilution

Lane 1:

Human fetal brain lysate

Lane 2:

Human fetal heart lysate

Lane 3:

Human fetal lung lysate

Lane 4:

Human fetal colon lysate

Predicted band size: 48 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human INPP5A aa 100-350. The exact immunogen used to generate this antibody is proprietary information.

Q14642

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Lyophilized
Reconstitution
Reconstitute in 200 µL of water
Purification technique
Affinity purification Immunogen
Purification notes
ab118418 is purified by a protein affinity column.
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

INPP5A also known as Inositol Polyphosphate-5-Phosphatase A plays a role in cellular signaling by dephosphorylating inositol phosphates. The protein has a molecular mass of approximately 44 kDa. This enzyme mainly expresses in the brain and skin tissues where it carries out its signaling functions. INPP5A acts on substrates such as inositol 145-trisphosphate (IP3) and inositol hexakisphosphate participating in the regulation of various signaling pathways.
Biological function summary

INPP5A enzymes regulate calcium signaling and apoptosis through their phosphatase activity. By removing phosphate groups INPP5A enzymes contribute to the termination of inositol phosphate signaling which affects a wide variety of cell processes. This enzyme functions as a singular unit rather than part of a larger enzyme complex allowing it to target inositol phosphates independently. The control of these signaling pathways is important for maintaining proper cellular function and communicating signals within cells.

Pathways

INPP5A contributes to the phosphoinositide signaling pathway and calcium signaling pathway. Its phosphatase activity provides an important regulatory function modulating the levels of inositol phosphates and thereby affecting downstream signaling processes like calcium release. It relates to proteins such as IP3 receptors and other inositol phosphatases emphasizing its role in orchestrating complex signaling networks within cells.

Alterations in INPP5A activity have connections to spinocerebellar ataxia and certain skin disorders like psoriasis. Disrupted INPP5A expression or function can interfere with normal cellular signaling potentially leading to neurological symptoms or skin pathologies. In the context of these diseases INPP5A shows interactions with proteins involved in neurodegeneration and epidermal regulation highlighting its significance in maintaining homeostasis and disease prevention.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate (PubMed : 8013665, PubMed : 8626616, PubMed : 8769125). Plays a crucial role in the survival of cerebellar Purkinje cells (By similarity).
See full target information INPP5A
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Iranian biomedical journal 26:440-53 PubMed36437782

2022

INPP5A/HLA-G1/IL-10/MMP-21 Axis in Progression of Esophageal Squamous Cell Carcinoma

Applications

Unspecified application

Species

Unspecified reactive species

Sima Ardalan Khales,Azadeh Aarabi,Mohammad Reza Abbaszadegan,Mohammad Mahdi Forghanifard

The Journal of biological chemistry 289:10270-5 PubMed24596094

2014

Importin 8 regulates the transport of mature microRNAs into the cell nucleus.

Applications

Unspecified application

Species

Unspecified reactive species

Yao Wei,Limin Li,Dong Wang,Chen-Yu Zhang,Ke Zen
View all publications
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