Rabbit Polyclonal INPP5A antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human INPP5A aa 100-350.
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Publications
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- Iranian biomedical journal 26:440-532022INPP5A/HLA-G1/IL-10/MMP-21 Axis in Progression of Esophageal Squamous Cell CarcinomaApplications:Unspecified applicationReactive species:Unspecified reactive speciesSima Ardalan Khales,Azadeh Aarabi,Mohammad Reza Abbaszadegan,Mohammad Mahdi ForghanifardPubMed 36437782
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 1% BSA- Form
- Lyophilized
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human INPP5A aa 100-350. The exact immunogen used to generate this antibody is proprietary information. Database link Q14642
Reactivity data
Select an application| WB | IHC-P | |
|---|---|---|
| Human | Tested | Tested |
| Mouse | Predicted | Predicted |
| Rat | Predicted | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/1000.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100.00000 - 1/500.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
Target data
Function
Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate (PubMed:8013665, PubMed:8626616, PubMed:8769125). Plays a crucial role in the survival of cerebellar Purkinje cells (By similarity).
Alternative names
5PTASE, INPP5A, Inositol polyphosphate-5-phosphatase A, 43 kDa inositol polyphosphate 5-phosphatase, 5PTase
Recommended products
Rabbit Polyclonal INPP5A antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human INPP5A aa 100-350.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 1% BSA- Form
- Lyophilized
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human INPP5A aa 100-350. The exact immunogen used to generate this antibody is proprietary information. Database link Q14642
- Purification technique
- Affinity purification Immunogen
- Reconstitution
- Reconstitute in 200 µL of water
- Concentration
- Purification notes
ab118418 is purified by a protein affinity column.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
INPP5A also known as Inositol Polyphosphate-5-Phosphatase A plays a role in cellular signaling by dephosphorylating inositol phosphates. The protein has a molecular mass of approximately 44 kDa. This enzyme mainly expresses in the brain and skin tissues where it carries out its signaling functions. INPP5A acts on substrates such as inositol 145-trisphosphate (IP3) and inositol hexakisphosphate participating in the regulation of various signaling pathways.
- Biological function summary
INPP5A enzymes regulate calcium signaling and apoptosis through their phosphatase activity. By removing phosphate groups INPP5A enzymes contribute to the termination of inositol phosphate signaling which affects a wide variety of cell processes. This enzyme functions as a singular unit rather than part of a larger enzyme complex allowing it to target inositol phosphates independently. The control of these signaling pathways is important for maintaining proper cellular function and communicating signals within cells.
- Pathways
INPP5A contributes to the phosphoinositide signaling pathway and calcium signaling pathway. Its phosphatase activity provides an important regulatory function modulating the levels of inositol phosphates and thereby affecting downstream signaling processes like calcium release. It relates to proteins such as IP3 receptors and other inositol phosphatases emphasizing its role in orchestrating complex signaling networks within cells.
- Associated diseases and disorders
Alterations in INPP5A activity have connections to spinocerebellar ataxia and certain skin disorders like psoriasis. Disrupted INPP5A expression or function can interfere with normal cellular signaling potentially leading to neurological symptoms or skin pathologies. In the context of these diseases INPP5A shows interactions with proteins involved in neurodegeneration and epidermal regulation highlighting its significance in maintaining homeostasis and disease prevention.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Western blot - Anti-INPP5A antibody (ab118418)
All lanes: Western blot - Anti-INPP5A antibody (ab118418) at 1/500 dilution
Lane 1: Human fetal brain lysate
Lane 2: Human fetal heart lysate
Lane 3: Human fetal lung lysate
Lane 4: Human fetal colon lysate
Predicted band size: 48 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-INPP5A antibody (ab118418)
ab118418, at 1/100 dilution, staining INPPA5 in paraffin-embedded Human fetal spleen tissue by Immunohistochemistry.
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