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AB95995

Anti-INPP5B antibody

5

(1 Review)

|

(1 Publication)

Rabbit Polyclonal INPP5B antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.

View Alternative Names

OCRL2, INPP5B, 75 kDa inositol polyphosphate-5-phosphatase, Phosphoinositide 5-phosphatase, 5PTase

1 Images
Western blot - Anti-INPP5B antibody (AB95995)
  • WB

Unknown

Western blot - Anti-INPP5B antibody (AB95995)

7.5% SDS PAGE

All lanes:

Western blot - Anti-INPP5B antibody (ab95995) at 1/1000 dilution

All lanes:

H1299 whole cell lysate at 30 µg

Predicted band size: 113 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

INPP5B or Type II inositol polyphosphate-5-phosphatase B catalyzes the dephosphorylation of phosphatidylinositol 45-bisphosphate. This enzyme removes the 5-phosphate group from inositol phosphates impacting phosphoinositide signaling pathways. The protein has a mass of approximately 75 kDa and is mainly expressed in the cytosol of cells including kidney and testis tissues. Scientists also observe its expression in other tissues related to phosphoinositide metabolism and signaling.
Biological function summary

INPP5B regulates cellular processes by modulating signaling events. This protein controls calcium signal transduction impacting cell proliferation and motility. INPP5B is part of the inositol phosphate signaling complex which plays a role in maintaining cellular phosphoinositide balance. Its enzymatic activity influences diverse cellular functions important for normal developmental processes and homeostasis.

Pathways

INPP5B participates in the phosphatidylinositol signaling system and calcium signaling pathways. In the phosphatidylinositol pathway INPP5B interacts with other inositol polyphosphate phosphatases like SHIP1 and PTEN working together to regulate phosphoinositide turnover and cellular respond to stimuli. In calcium signaling it closely interacts with proteins controlling intracellular calcium levels thereby influencing diverse cellular responses.

INPP5B links to Lowe syndrome and Dent disease. Mutations affecting INPP5B's enzymatic activity can disrupt normal inositol phosphate metabolism impacting cellular functions and organ development. These diseases also show association with OCRL another inositol phosphatase. OCRL mutations share similar phenotypes with INPP5B dysfunctions causing similar disruptions in kidney and neurological systems highlighting their critical roles in maintaining phosphoinositide homeostasis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Regulates phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) cellular levels by cleaving the phosphate at the 5-position producing PtdIns(4)P. Also hydrolyzes the 5-position phosphate from inositol 1,4,5-trisphosphate (Ins(1,4,5)P3), thereby modulating cellular signaling events.
See full target information INPP5B
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular human reproduction 17:669-78 PubMed21593214

2011

Highly purified spermatozoal RNA obtained by a novel method indicates an unusual 28S/18S rRNA ratio and suggests impaired ribosome assembly.

Applications

Unspecified application

Species

Unspecified reactive species

Heike Cappallo-Obermann,Wolfgang Schulze,Holger Jastrow,Vera Baukloh,Andrej-Nikolai Spiess
View all publications
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Product promise

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For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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