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AB69696

Anti-INPP5E antibody

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(1 Publication)

Mouse Polyclonal INPP5E antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Phosphatidylinositol polyphosphate 5-phosphatase type IV.

View Alternative Names

Phosphatidylinositol polyphosphate 5-phosphatase type IV, 72 kDa inositol polyphosphate 5-phosphatase, Inositol polyphosphate-5-phosphatase E, INPP5E

1 Images
Western blot - Anti-INPP5E antibody (AB69696)
  • WB

Unknown

Western blot - Anti-INPP5E antibody (AB69696)

All lanes:

Western blot - Anti-INPP5E antibody (ab69696) at 1/500 dilution

Lane 1:

INPP5E transfected 293T cell lysate at 25 µg

Lane 2:

Non-transfected 293T cell lysate at 25 µg

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Predicted band size: 70 kDa

Observed band size: 70 kDa

false

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human Phosphatidylinositol polyphosphate 5-phosphatase type IV.

Q9NRR6

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
pH: 7.4 Constituents: 100% PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

INPP5E also known as type I inositol polyphosphate-5-phosphatase plays a significant role as an enzyme regulating phosphoinositide signaling. This protein has a molecular mass of approximately 72 kDa. INPP5E cleaves the 5-phosphate from phosphoinositides affecting cellular processes. It is widely expressed in various tissues with notable presence in the brain and testis indicating its importance in these tissue types.
Biological function summary

INPP5E is involved in maintaining phosphoinositide balance within cells which regulates cellular signaling pathways. It is essential for the function of primary cilia by controlling ciliary membrane composition. This protein often interacts with components of the ciliary transition zone forming part of the complex that regulates trafficking proteins and movement.

Pathways

INPP5E engages in the phosphoinositide signaling pathway and the ciliary signaling pathway. It influences the activity of proteins such as phosphatidylinositol and adenylyl cyclase playing a role in signaling cascades that affect cell metabolism and spatial orientation. Disruption in its function can alter these signaling pathways demonstrating its importance in cellular communication and function.

Studies link INPP5E to Joubert syndrome and Meckel syndrome conditions affecting ciliary function. These ciliopathies are marked by abnormal brain development and a range of other symptoms. INPP5E interacts with proteins like ARL13B and CEP290 which are also associated with these disorders highlighting its integral role in maintaining healthy ciliary architecture and function.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity) (PubMed : 10764818). Specific for lipid substrates, inactive towards water soluble inositol phosphates (PubMed : 10764818). Plays an essential role in the primary cilium by controlling ciliary growth and phosphoinositide 3-kinase (PI3K) signaling and stability (By similarity).
See full target information Phosphatidylinositol polyphosphate 5-phosphatase type IV
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 29:4010-4023.e5 PubMed31851930

2019

Induction of an Alternative mRNA 5' Leader Enhances Translation of the Ciliopathy Gene Inpp5e and Resistance to Oncolytic Virus Infection.

Applications

Unspecified application

Species

Unspecified reactive species

Huy-Dung Hoang,Tyson E Graber,Jian-Jun Jia,Nasana Vaidya,Victoria H Gilchrist,Xiao Xiang,Wencheng Li,Kyle N Cowan,Christos G Gkogkas,Maritza Jaramillo,Seyed Mehdi Jafarnejad,Tommy Alain
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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Associated Products

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