Mouse Monoclonal Insulin antibody. Carrier free. Suitable for ELISA, IHC-P, RIA, FuncS, ICC/IF and reacts with Pig, Human, Cow samples. Cited in 6 publications. Immunogen corresponding to Full Length Protein corresponding to Pig INS.
IgG1
Mouse
pH: 7.4
Constituents: 100% PBS
Liquid
Monoclonal
| ELISA | IHC-P | RIA | FuncS | ICC/IF | |
|---|---|---|---|---|---|
| Human | Expected | Expected | Expected | Expected | Expected |
| Cow | Expected | Expected | Expected | Expected | Expected |
| Pig | Expected | Expected | Expected | Expected | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Pig, Human, Cow | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Pig, Human, Cow | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Pig, Human, Cow | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Pig | Dilution info - | Notes Blocks the binding of insulin to the receptor. |
Species Human | Dilution info - | Notes Blocks the binding of insulin to the receptor. |
Species Cow | Dilution info - | Notes Blocks the binding of insulin to the receptor. |
| Species | Dilution info | Notes |
|---|---|---|
Species Pig, Human, Cow | Dilution info Use at an assay dependent concentration. | Notes - |
Select an associated product type
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
Insulin, INS
Mouse Monoclonal Insulin antibody. Carrier free. Suitable for ELISA, IHC-P, RIA, FuncS, ICC/IF and reacts with Pig, Human, Cow samples. Cited in 6 publications. Immunogen corresponding to Full Length Protein corresponding to Pig INS.
Insulin, INS
IgG1
Mouse
pH: 7.4
Constituents: 100% PBS
Liquid
Monoclonal
Yes
IN-05
Affinity purification Protein A
The antibody blocks binding of insulin to the receptor.
Purified from TCS. Purity >95% by SDS-PAGE. Preserved by filter sterilization.
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
This product was changed from ascites to tissue culture supernatant. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.
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This supplementary information is collated from multiple sources and compiled automatically.
Insulin a peptide hormone plays an essential mechanical role in carbohydrate and fat metabolism. Insulin alternatively known as bovine insulin in some research contexts has a molecular mass of around 5800 Da. Beta cells in the pancreas express insulin where it gets secreted directly into the bloodstream. The hormone regulates glucose levels by facilitating the uptake of glucose into cells such as muscle and adipose tissues.
Insulin influences several key metabolic processes by binding to its receptor a component of the insulin receptor substrate family. This triggers a cascade of events within cells promoting the uptake of glucose and converting it into energy. Insulin operates as a singular entity but plays a critical role in forming a complex with its receptor. This interaction triggers downstream effects that alter the activity of enzymes and transcription factors involved in glucose and lipid metabolism.
Insulin is critical for the regulation of the PI3K-AKT signaling pathway and the MAPK pathway. These pathways modulate processes such as cell growth proliferation and survival. Insulin interacts closely with other proteins in these pathways such as the insulin receptor substrate proteins and influences downstream proteins like AKT kinase which has a significant role in mediating the metabolic effects initiated by insulin binding.
Insulin is most notably linked to diabetes mellitus characterized by insufficient insulin production or action. This deficiency disrupts normal glucose homeostasis leading to hyperglycemia. Other associated proteins include glucagon which counteracts insulin's role in lowering blood glucose levels and IRS-1 an important element through which insulin signaling is transduced. Researchers utilize mouse insulin ELISA and insulin ELISA kits to better understand these relationships and develop treatments for insulin-related disorders.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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