Rabbit Polyclonal Integrin alpha 1 antibody. C-terminal. Suitable for IHC-P, WB and reacts with Rat, Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human ITGA1 aa 1100-1150.
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- Cell 185:3753-3769.e182022Ensembles of endothelial and mural cells promote angiogenesis in prenatal human brain.Applications:Unspecified applicationReactive species:Unspecified reactive speciesElizabeth E Crouch,Aparna Bhaduri,Madeline G Andrews,Arantxa Cebrian-Silla,Loukas N Diafos,Janeth Ochoa Birrueta,Kaylee Wedderburn-Pugh,Edward J Valenzuela,Neal K Bennett,Ugomma C Eze,Carmen Sandoval-Espinosa,Jiapei Chen,Cristina Mora,Jayden M Ross,Clare E Howard,Susana Gonzalez-Granero,Jaime Ferrer Lozano,Maximo Vento,Maximilian Haeussler,Mercedes F Paredes,Ken Nakamura,Jose Manuel Garcia-Verdugo,Arturo Alvarez-Buylla,Arnold R Kriegstein,Eric J HuangPubMed 36179668
- Cancer research 82:2031-20442022Chemotherapy-Induced Collagen IV Drives Cancer Cell Motility through Activation of Src and Focal Adhesion Kinase.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJackson P Fatherree,Justinne R Guarin,Rachel A McGinn,Stephen P Naber,Madeleine J OudinPubMed 35260882
- Reproductive sciences (Thousand Oaks, Calif.) 28:207-2172020Proteomic Analysis of Uterine Tissues During Peri-Implantation Period in Mice with Experimentally Induced Adenomyosis that Treated with anti-Ngf: Implications for Cell-Cell Adhesion and Metabolic Processes.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYan Li,Dan Zhang,Bailing Jin,Lan Xia,Aijun ZhangPubMed 32676925
- Oncoimmunology 7:e14908552018Formation and phenotypic characterization of CD49a, CD49b and CD103 expressing CD8 T cell populations in human metastatic melanoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMarit M Melssen et. al.PubMed 30288359
- Scientific reports 7:100602017ITGA1 is a pre-malignant biomarker that promotes therapy resistance and metastatic potential in pancreatic cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesArmen Gharibi et. al.PubMed 28855593
- Nature communications 8:2242017Activated NK cells cause placental dysfunction and miscarriages in fetal alloimmune thrombocytopenia.Applications:Unspecified applicationReactive species:Unspecified reactive speciesIssaka Yougbaré et. al.PubMed 28794456
- Circulation. Cardiovascular genetics 10:2017Osteoprotegerin Disruption Attenuates HySu-Induced Pulmonary Hypertension Through Integrin αvβ3/FAK/AKT Pathway Suppression.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDaile Jia,Qian Zhu,Huan Liu,Caojian Zuo,Yuhu He,Guilin Chen,Ankang LuPubMed 28077433
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Constituents: 1.6% Trehalose, 0.36% Sodium chloride, 0.08% Sodium dihydrogen phosphate
- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human ITGA1 aa 1100-1150. The exact immunogen used to generate this antibody is proprietary information. Database link P56199
Reactivity data
Select an application| IHC-P | WB | |
|---|---|---|
| Human | Tested | Expected |
| Mouse | Predicted | Predicted |
| Rat | Tested | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info 0.50000-1.00000 µg/mL | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Species Human | Dilution info 0.50000-1.00000 µg/mL | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info - | Notes - |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info 0.50000-1.00000 µg/mL | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info - | Notes - |
Associated Products
Select an associated product type
5 products for Alternative Product
Target data
Function
Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.
Alternative names
CD49a, Integrin alpha-1, CD49 antigen-like family member A, Laminin and collagen receptor, VLA-1, ITGA1
Recommended products
Rabbit Polyclonal Integrin alpha 1 antibody. C-terminal. Suitable for IHC-P, WB and reacts with Rat, Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human ITGA1 aa 1100-1150.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Constituents: 1.6% Trehalose, 0.36% Sodium chloride, 0.08% Sodium dihydrogen phosphate
- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human ITGA1 aa 1100-1150. The exact immunogen used to generate this antibody is proprietary information. Database link P56199
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Integrin alpha 1 also called CD49a is a protein that functions as a mechanical link between cells and the extracellular matrix. It is part of the integrin protein family and partners with beta 1 integrin to form the integrin alpha 1 beta 1 complex. This protein is a heterodimer and weighs approximately 180 kDa. The integrin alpha 1 is expressed in various tissues including the dermis cartilage and the immune system especially on activated T cells and natural killer cells.
- Biological function summary
Integrin alpha 1 beta 1 mediates cell adhesion and migration. It plays an important role in collagen binding influencing various cellular processes like proliferation and differentiation. Integrin alpha 1 forms a complex with ligand molecules notably collagen which assists in remodeling the extracellular matrix. This activity contributes to the development and repair of tissues offering structural support and pathways for cell signaling events.
- Pathways
Integrin alpha 1 engages in the MAPK signaling pathway and regulation of the TGF-beta signaling cascade. By mediating interactions between cells and their environment it influences downstream signaling and gene expression. Integrins including integrin alpha 1 have roles in pathways related to cellular stress responses and signal modulation interacting with proteins such as fibronectin within these processes.
- Associated diseases and disorders
Integrin alpha 1 has been linked to fibrosis and chronic inflammatory diseases. By modulating matrix-related signals it influences the pathology of fibrosis through upregulation of matrix metalloproteinases. In chronic inflammatory diseases its interaction with collagen and other matrix proteins can affect immune cell trafficking and signaling. Understanding these connections helps in exploring potential therapeutic targets and interventions.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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In the unlikely event of one of our products not working as expected, you are covered by our product promise.
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4 product images
Western blot - Anti-Integrin alpha 1 antibody - C-terminal (ab181434)
All lanes: Western blot - Anti-Integrin alpha 1 antibody - C-terminal (ab181434) at 0.5 µg/mL
Lane 1: Rat Brain Tissue Lysate at 50 µg
Lane 2: HeLa Whole Cell Lysate at 50 µg
Lane 3: SW620 Whole Cell Lysate at 50 µg
Predicted band size: 130 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Integrin alpha 1 antibody - C-terminal (ab181434)
Immunohistochemical analysis of paraffin embedded rat intestine tissue labeling Integrin alpha 1 with ab181434 at 1.0 μg/ml.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Integrin alpha 1 antibody - C-terminal (ab181434)
Immunohistochemical analysis of paraffin embedded Human intestinal cancer tissue labeling Integrin alpha 1 with ab181434 at 1.0 μg/ml.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Integrin alpha 1 antibody - C-terminal (ab181434)
Immunohistochemical analysis of paraffin embedded Human lung cancer tissue labeling Integrin alpha 1 with ab181434 at 1.0 μg/ml.
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