AB181434

Anti-Integrin alpha 1 antibody - C-terminal

Name: Anti-Integrin alpha 1 antibody - C-terminal (ab181434) | Abcam
Brand: Abcam Limited
SKU: AB181434
Price: 545 USD
Availability: InStock

(1 Review)

(9 Publications)

Rabbit Polyclonal Integrin alpha 1 antibody. C-terminal. Suitable for IHC-P, WB and reacts with Rat, Human samples. Cited in 9 publications. Immunogen corresponding to Synthetic Peptide within Human ITGA1 aa 1100-1150.

View Alternative Names

CD49a, Integrin alpha-1, CD49 antigen-like family member A, Laminin and collagen receptor, VLA-1, ITGA1

4 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Integrin alpha 1 antibody - C-terminal (AB181434)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Integrin alpha 1 antibody - C-terminal (AB181434)

Immunohistochemical analysis of paraffin embedded Human intestinal cancer tissue labeling Integrin alpha 1 with ab181434 at 1.0 μg/ml.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Integrin alpha 1 antibody - C-terminal (AB181434)

Immunohistochemical analysis of paraffin embedded Human lung cancer tissue labeling Integrin alpha 1 with ab181434 at 1.0 μg/ml.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Integrin alpha 1 antibody - C-terminal (AB181434)

Immunohistochemical analysis of paraffin embedded rat intestine tissue labeling Integrin alpha 1 with ab181434 at 1.0 μg/ml.

Supplier Data

Western blot - Anti-Integrin alpha 1 antibody - C-terminal (AB181434)

All lanes:

Western blot - Anti-Integrin alpha 1 antibody - C-terminal (ab181434) at 0.5 µg/mL

Lane 1:

Rat Brain Tissue Lysate at 50 µg

Lane 2:

HeLa Whole Cell Lysate at 50 µg

Lane 3:

SW620 Whole Cell Lysate at 50 µg

Predicted band size: 130 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat, Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human ITGA1 aa 1100-1150. The exact immunogen used to generate this antibody is proprietary information.

P56199

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "0.5-1 µg/mL", "IHCP-species-notes": " Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "0.5-1 µg/mL", "IHCP-species-notes": " Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-1 µg/mL", "WB-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

Constituents: 1.6% Trehalose, 0.36% Sodium chloride, 0.08% Sodium dihydrogen phosphate

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Integrin alpha 1 also called CD49a is a protein that functions as a mechanical link between cells and the extracellular matrix. It is part of the integrin protein family and partners with beta 1 integrin to form the integrin alpha 1 beta 1 complex. This protein is a heterodimer and weighs approximately 180 kDa. The integrin alpha 1 is expressed in various tissues including the dermis cartilage and the immune system especially on activated T cells and natural killer cells.

Biological function summary

Integrin alpha 1 beta 1 mediates cell adhesion and migration. It plays an important role in collagen binding influencing various cellular processes like proliferation and differentiation. Integrin alpha 1 forms a complex with ligand molecules notably collagen which assists in remodeling the extracellular matrix. This activity contributes to the development and repair of tissues offering structural support and pathways for cell signaling events.

Pathways

Integrin alpha 1 engages in the MAPK signaling pathway and regulation of the TGF-beta signaling cascade. By mediating interactions between cells and their environment it influences downstream signaling and gene expression. Integrins including integrin alpha 1 have roles in pathways related to cellular stress responses and signal modulation interacting with proteins such as fibronectin within these processes.

Integrin alpha 1 has been linked to fibrosis and chronic inflammatory diseases. By modulating matrix-related signals it influences the pathology of fibrosis through upregulation of matrix metalloproteinases. In chronic inflammatory diseases its interaction with collagen and other matrix proteins can affect immune cell trafficking and signaling. Understanding these connections helps in exploring potential therapeutic targets and interventions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.

See full target information ITGA1

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Publications (9)

Recent publications for all applications. Explore the full list and refine your search

Investigative ophthalmology & visual science 66:22 PubMed39918477

2025

Extracellular Matrix Stiffness Modulates Myopia Scleral Remodeling Through Integrin/F-Actin/YAP Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Xin Liu,Ying Yuan,Yue Wu,Chengcheng Zhu,Yuying Liu,Bilian Ke

Small (Weinheim an der Bergstrasse, Germany) 19:e2301426 PubMed37271895

2023

Magnetic Field Boosts the Transmembrane Transport Efficiency of Magnesium Ions from PLLA Bone Scaffold.

Applications

Unspecified application

Species

Unspecified reactive species

Zuyun Yan,Tianshi Sun,Wei Tan,Zhicheng Wang,Jinpeng Yan,Jinglei Miao,Xin Wu,Pei Feng,Youwen Deng

Cell 185:3753-3769.e18 PubMed36179668

2022

Ensembles of endothelial and mural cells promote angiogenesis in prenatal human brain.

Applications

Unspecified application

Species

Unspecified reactive species

Elizabeth E Crouch,Aparna Bhaduri,Madeline G Andrews,Arantxa Cebrian-Silla,Loukas N Diafos,Janeth Ochoa Birrueta,Kaylee Wedderburn-Pugh,Edward J Valenzuela,Neal K Bennett,Ugomma C Eze,Carmen Sandoval-Espinosa,Jiapei Chen,Cristina Mora,Jayden M Ross,Clare E Howard,Susana Gonzalez-Granero,Jaime Ferrer Lozano,Maximo Vento,Maximilian Haeussler,Mercedes F Paredes,Ken Nakamura,Jose Manuel Garcia-Verdugo,Arturo Alvarez-Buylla,Arnold R Kriegstein,Eric J Huang

Cancer research 82:2031-2044 PubMed35260882

2022

Chemotherapy-Induced Collagen IV Drives Cancer Cell Motility through Activation of Src and Focal Adhesion Kinase.

Applications

Unspecified application

Species

Unspecified reactive species

Jackson P Fatherree,Justinne R Guarin,Rachel A McGinn,Stephen P Naber,Madeleine J Oudin

Reproductive sciences (Thousand Oaks, Calif.) 28:207-217 PubMed32676925

2020

Proteomic Analysis of Uterine Tissues During Peri-Implantation Period in Mice with Experimentally Induced Adenomyosis that Treated with anti-Ngf: Implications for Cell-Cell Adhesion and Metabolic Processes.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Li,Dan Zhang,Bailing Jin,Lan Xia,Aijun Zhang

Oncoimmunology 7:e1490855 PubMed30288359

2018

Formation and phenotypic characterization of CD49a, CD49b and CD103 expressing CD8 T cell populations in human metastatic melanoma.

Applications

Unspecified application

Species

Unspecified reactive species

Marit M Melssen,Walter Olson,Nolan A Wages,Brian J Capaldo,Ileana S Mauldin,Adela Mahmutovic,Ciara Hutchison,Cornelis J M Melief,Timothy N Bullock,Victor H Engelhard,Craig L Slingluff

Scientific reports 7:10060 PubMed28855593

2017

ITGA1 is a pre-malignant biomarker that promotes therapy resistance and metastatic potential in pancreatic cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Armen Gharibi,Sa La Kim,Justin Molnar,Daniel Brambilla,Yvess Adamian,Malachia Hoover,Julie Hong,Joy Lin,Laurelin Wolfenden,Jonathan A Kelber

Nature communications 8:224 PubMed28794456

2017

Activated NK cells cause placental dysfunction and miscarriages in fetal alloimmune thrombocytopenia.

Applications

Unspecified application

Species

Unspecified reactive species

Issaka Yougbaré,Wei-She Tai,Darko Zdravic,Brigitta Elaine Oswald,Sean Lang,Guangheng Zhu,Howard Leong-Poi,Dawei Qu,Lisa Yu,Caroline Dunk,Jianhong Zhang,John G Sled,Stephen J Lye,Jelena Brkić,Chun Peng,Petter Höglund,B Anne Croy,S Lee Adamson,Xiao-Yan Wen,Duncan J Stewart,John Freedman,Heyu Ni

Circulation. Cardiovascular genetics 10: PubMed28077433

2017

Osteoprotegerin Disruption Attenuates HySu-Induced Pulmonary Hypertension Through Integrin αvβ3/FAK/AKT Pathway Suppression.

Applications

Unspecified application

Species

Unspecified reactive species

Daile Jia,Qian Zhu,Huan Liu,Caojian Zuo,Yuhu He,Guilin Chen,Ankang Lu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Integrin alpha 1 antibody - C-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Integrin alpha 1 antibody - C-terminal (AB181434)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Integrin alpha 1 antibody - C-terminal (AB181434)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Integrin alpha 1 antibody - C-terminal (AB181434)

Western blot - Anti-Integrin alpha 1 antibody - C-terminal (AB181434)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (9)

Product promise