AB34445

Anti-Integrin alpha 1 antibody [TS2/7]

Name: Anti-Integrin alpha 1 antibody [TS2/7] (ab34445) | Abcam
Brand: Abcam Limited
SKU: AB34445
Price: 450 USD
Availability: InStock
Rating: 3 (1 reviews)

(1 Review)

(3 Publications)

Mouse Monoclonal Integrin alpha 1 antibody. Suitable for Flow Cyt and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Cell preparation containing ITGA1 protein.

View Alternative Names

CD49a, Integrin alpha-1, CD49 antigen-like family member A, Laminin and collagen receptor, VLA-1, ITGA1

1 Images

Flow Cytometry - Anti-Integrin alpha 1 antibody [TS2/7] (AB34445)

Flow Cyt

Unknown

Flow Cytometry - Anti-Integrin alpha 1 antibody [TS2/7] (AB34445)

Staining of HeLa cells with MOUSE ANTI HUMAN CD49a (ab34445).

519 FITC

FITC Anti-Integrin alpha 1 antibody [TS2/7]

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

TS2/7

Isotype

IgG1

Carrier free

Reacts with

Human

Applications

Flow Cyt

applications

Immunogen

Cell preparation containing ITGA1 protein. The exact immunogen used to generate this antibody is proprietary information.

P56199

Specificity

ab34445 recognises alpha 1 integrin subunit.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1/25 - 1/50", "FlowCyt-species-notes": "Use 10μl of the suggested working dilution to label 106 cells in 100μl.<a href='/en-us/products/primary-antibodies/mouse-igg1-kappa-monoclonal-15-6e10a7-isotype-control-ab170190'>ab170190</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody." } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Purification notes

Purified from tissue culture supernatant.

Storage buffer

pH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Integrin alpha 1 also called CD49a is a protein that functions as a mechanical link between cells and the extracellular matrix. It is part of the integrin protein family and partners with beta 1 integrin to form the integrin alpha 1 beta 1 complex. This protein is a heterodimer and weighs approximately 180 kDa. The integrin alpha 1 is expressed in various tissues including the dermis cartilage and the immune system especially on activated T cells and natural killer cells.

Biological function summary

Integrin alpha 1 beta 1 mediates cell adhesion and migration. It plays an important role in collagen binding influencing various cellular processes like proliferation and differentiation. Integrin alpha 1 forms a complex with ligand molecules notably collagen which assists in remodeling the extracellular matrix. This activity contributes to the development and repair of tissues offering structural support and pathways for cell signaling events.

Pathways

Integrin alpha 1 engages in the MAPK signaling pathway and regulation of the TGF-beta signaling cascade. By mediating interactions between cells and their environment it influences downstream signaling and gene expression. Integrins including integrin alpha 1 have roles in pathways related to cellular stress responses and signal modulation interacting with proteins such as fibronectin within these processes.

Integrin alpha 1 has been linked to fibrosis and chronic inflammatory diseases. By modulating matrix-related signals it influences the pathology of fibrosis through upregulation of matrix metalloproteinases. In chronic inflammatory diseases its interaction with collagen and other matrix proteins can affect immune cell trafficking and signaling. Understanding these connections helps in exploring potential therapeutic targets and interventions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.

See full target information ITGA1

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

PloS one 11:e0148906 PubMed26848974

2016

Integrin Ligation Results in Nephrin Tyrosine Phosphorylation In Vitro.

Applications

Unspecified application

Species

Unspecified reactive species

Rakesh Verma,Madhusudan Venkatareddy,Anne Kalinowski,Sanjeevkumar R Patel,Puneet Garg

Oncotarget 7:5289-305 PubMed26700621

2015

VE-cadherin cleavage by ovarian cancer microparticles induces β-catenin phosphorylation in endothelial cells.

Applications

Species

Unspecified reactive species

Hamda Al Thawadi,Nadine Abu-Kaoud,Haleema Al Farsi,Jessica Hoarau-Véchot,Shahin Rafii,Arash Rafii,Jennifer Pasquier

The Journal of clinical investigation 124:3295-310 PubMed24983314

2014

Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling.

Applications

Flow Cyt, IHC-Fr

Species

Human, Human

Xiwu Chen,Hongtao Wang,Hong-Jun Liao,Wen Hu,Leslie Gewin,Glenda Mernaugh,Sheng Zhang,Zhong-Yin Zhang,Lorenzo Vega-Montoto,Roberto M Vanacore,Reinhard Fässler,Roy Zent,Ambra Pozzi

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Integrin alpha 1 antibody [TS2/7]

Flow Cytometry - Anti-Integrin alpha 1 antibody [TS2/7] (AB34445)

Related conjugates and formulations (1)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

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