Sample Prep & Detection Kits
Conjugation kitsPurification kitsSample preparation kitsChromogen kitsIHC kitsChIP kitsAccessory Reagents & Controls
Accessory reagents & controlsBiochemicals
BiochemicalsProteins and Peptides
Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
Learn about all product ranges with our product overviews.
Featured events
Make new connections at our global events.
Our programs
New Lab Program
Get a head start with our exclusive new lab discount. Enjoy 20% off and free shipping for three months.
New Biotech Program
Just starting out? Get 15% off and free shipping to your lab for six months.
Product promise
Peace of mind that all products perform as stated.
Product reviews
Leave reviews, get rewarded and help your community.
Trial program
Try untested species and applications to earn money off your next order.
Product Insider Program
Be the first to know about our latest product launches - and unlock exclusive offers and discounts.
Rabbit Polyclonal Integrin alpha 3 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human ITGA3.
IgG
Rabbit
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS
Liquid
Polyclonal
IHC-P | |
---|---|
Human | Tested |
Mouse | Predicted |
Bat | Predicted |
Common marmoset | Predicted |
Cow | Predicted |
Dog | Predicted |
Elephant | Predicted |
Gorilla | Predicted |
Hamster | Predicted |
Horse | Predicted |
Monkey | Predicted |
Opossum | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 7.50000-10.00000 µg/mL | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Species | Dilution info | Notes |
---|---|---|
Species Mouse, Horse, Hamster, Cow, Dog, Monkey, Gorilla, Opossum, Common marmoset, Bat, Elephant | Dilution info - | Notes - |
Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.
Integrin alpha-3, CD49 antigen-like family member C, FRP-2, Galactoprotein B3, VLA-3 subunit alpha, GAPB3, ITGA3, MSK18
Rabbit Polyclonal Integrin alpha 3 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human ITGA3.
Integrin alpha-3, CD49 antigen-like family member C, FRP-2, Galactoprotein B3, VLA-3 subunit alpha, GAPB3, ITGA3, MSK18
IgG
Rabbit
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS
Liquid
Polyclonal
Affinity purification Immunogen
BLAST analysis of the peptide immunogen showed no homology with other Human proteins.
Blue Ice
-80°C
Upon delivery aliquot
Avoid freeze / thaw cycle
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Integrin alpha 3 functions as a cell surface receptor that helps regulate cell migration proliferation and differentiation. It is a part of the alpha-3-beta-1 integrin complex which interacts with extracellular proteins like laminin-5 and collagen. This interaction facilitates the transmission of signals from the outside to the inside of the cell affecting various cellular responses and activities.
Integrin alpha 3 also known as ITGA3 or alpha 3 is a protein that plays an important role in cell adhesion and signaling. It forms complexes with other integrins to mediate interactions between cells and the extracellular matrix. Integrin alpha 3 is a type I transmembrane protein with a molecular weight of approximately 120 kDa. This protein is primarily expressed in epithelial tissues including the skin kidneys and respiratory tract.
Integrin alpha 3 plays a significant role in the cell signaling and communication pathways. It is involved in the pathways like focal adhesion and MAPK signaling. In these pathways integrin alpha 3 interacts with other proteins such as paxillin and FAK (focal adhesion kinase) which are critical for the downstream signaling that regulates cell shape and movement.
Integrin alpha 3 is linked to conditions like skin blistering diseases and cancers particularly those affecting the epithelial tissues. Alterations in integrin alpha 3 expression or function can disturb cell adhesion leading to diseases like epidermolysis bullosa. Additionally in cancer integrin alpha 3 often collaborates with proteins like MMP-9 to promote tumor invasion and metastasis.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
Immunohistochemical analysis of paraffin-embedded, formalin-fixed Human skin tissue labelling Integrin alpha 3 with ab133198 at 10 μg/ml,
Immunohistochemical analysis of paraffin-embedded, formalin-fixed Human colon, smooth muscle, tissue labelling Integrin alpha 3 with ab133198 at 10 μg/ml, followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com