AB20141

Anti-Integrin alpha 3 antibody [IA3]

Name: Anti-Integrin alpha 3 antibody [IA3] (ab20141) | Abcam
Brand: Abcam Limited
SKU: AB20141
Price: 525 USD
Availability: InStock

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(3 Publications)

Mouse Monoclonal Integrin alpha 3 antibody. Suitable for FuncS, IHC-Fr and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Cell preparation containing ITGA3 protein.

View Alternative Names

CD49c, MSK18, ITGA3, Integrin alpha-3, CD49 antigen-like family member C, FRP-2, Galactoprotein B3, VLA-3 subunit alpha, GAPB3

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

IA3

Isotype

IgG1

Light chain type

unknown

Carrier free

Reacts with

Human

Applications

IHC-Fr, FuncS

applications

Immunogen

Cell preparation containing ITGA3 protein. The exact immunogen used to generate this antibody is proprietary information.

P26006

Specificity

Specific to alpha 3 integrin. IA3 is useful for studies on inhibition of cell-cell adhesion and cell-substrate adhesion.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FuncS" : {"fullname" : "Functional Studies", "shortname":"FuncS"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FuncS-species-checked": "guaranteed", "FuncS-species-dilution-info": "", "FuncS-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" } } }

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Product details

Fusion partner: NS2

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A/G

Storage buffer

Preservative: 0.02% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Integrin alpha 3 also known as ITGA3 or alpha 3 is a protein that plays an important role in cell adhesion and signaling. It forms complexes with other integrins to mediate interactions between cells and the extracellular matrix. Integrin alpha 3 is a type I transmembrane protein with a molecular weight of approximately 120 kDa. This protein is primarily expressed in epithelial tissues including the skin kidneys and respiratory tract.

Biological function summary

Integrin alpha 3 functions as a cell surface receptor that helps regulate cell migration proliferation and differentiation. It is a part of the alpha-3-beta-1 integrin complex which interacts with extracellular proteins like laminin-5 and collagen. This interaction facilitates the transmission of signals from the outside to the inside of the cell affecting various cellular responses and activities.

Pathways

Integrin alpha 3 plays a significant role in the cell signaling and communication pathways. It is involved in the pathways like focal adhesion and MAPK signaling. In these pathways integrin alpha 3 interacts with other proteins such as paxillin and FAK (focal adhesion kinase) which are critical for the downstream signaling that regulates cell shape and movement.

Integrin alpha 3 is linked to conditions like skin blistering diseases and cancers particularly those affecting the epithelial tissues. Alterations in integrin alpha 3 expression or function can disturb cell adhesion leading to diseases like epidermolysis bullosa. Additionally in cancer integrin alpha 3 often collaborates with proteins like MMP-9 to promote tumor invasion and metastasis.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.. (Microbial infection) Integrin ITGA3 : ITGB1 may act as a receptor for R.delemar CotH7 in alveolar epithelial cells, which may be an early step in pulmonary mucormycosis disease progression.

See full target information ITGA3

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Bioactive materials 10:32-47 PubMed34901527

2021

Magnesium cationic cue enriched interfacial tissue microenvironment nurtures the osseointegration of gamma-irradiated allograft bone.

Applications

Unspecified application

Species

Unspecified reactive species

Wenhao Wang,Jie Shen,Yuan Meng,Miaoman Ye,Shaozhang Lin,Qi Zhao,Le Wang,Kenneth M C Cheung,Shuilin Wu,Yufeng Zheng,Xuanyong Liu,Paul K Chu,Kelvin W K Yeung,Zhi-Yong Zhang

Matrix biology : journal of the International Soci 90:61-78 PubMed32147508

2020

Basement membrane ligands initiate distinct signalling networks to direct cell shape.

Applications

Unspecified application

Species

Unspecified reactive species

Michael J Randles,Franziska Lausecker,Jonathan D Humphries,Adam Byron,Simon J Clark,Jeffrey H Miner,Roy Zent,Martin J Humphries,Rachel Lennon

Journal of cell science 107 ( Pt 12):3557-68 PubMed7535787

1994

Branching morphogenesis of human mammary epithelial cells in collagen gels.

Applications

Unspecified application

Species

Unspecified reactive species

F Berdichevsky,D Alford,B D'Souza,J Taylor-Papadimitriou

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Integrin alpha 3 antibody [IA3]

Key facts

Host species

Clonality

Clone number

Isotype

Light chain type

Carrier free

Reacts with

Applications

Immunogen

Specificity

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

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