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Mouse Monoclonal Integrin alpha 3 antibody. Suitable for ICC, WB, IHC-Fr and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Human Integrin alpha-3 conjugated to Keyhole Limpet Haemocyanin.

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Publications

Key facts

Isotype

IgG1

Host species

Mouse

Storage buffer

Preservative: 0.09% Sodium azide
Constituents: PBS

Form

Liquid

Clonality

Monoclonal

Immunogen

  • Synthetic Peptide within Human Integrin alpha-3 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link P26006

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
ICCWBIHC-Fr
Human
Expected
Expected
Expected

Expected
Expected

Species

Human

Dilution info

Use at an assay dependent concentration.

Notes

-

Expected
Expected

Species

Human

Dilution info

Use at an assay dependent concentration.

Notes

-

Expected
Expected

Species

Human

Dilution info

Use at an assay dependent concentration.

Notes

-

Target data

Function

Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.(Microbial infection) Integrin ITGA3:ITGB1 may act as a receptor for R.delemar CotH7 in alveolar epithelial cells, which may be an early step in pulmonary mucormycosis disease progression.

Alternative names

Recommended products

Mouse Monoclonal Integrin alpha 3 antibody. Suitable for ICC, WB, IHC-Fr and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Human Integrin alpha-3 conjugated to Keyhole Limpet Haemocyanin.

Key facts

Isotype

IgG1

Form

Liquid

Clonality

Monoclonal

Immunogen
  • Synthetic Peptide within Human Integrin alpha-3 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link P26006
Clone number

54B3

Purification technique

Affinity purification Protein G

Specificity

Recognizes specifically the cytoplasmic domain of integrin subunit a3B which is present in microvascular structures in brain and heart.

Epitope

Cytoplasmic domain of a3B Integrin.

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

The integrins, finally, form a large family of glycosylated transmembrane proteins that act as dimers of an alpha and a beta subunit in interconnecting the cytoskeleton and the extracellular matrix.

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Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Integrin alpha 3b also known as ITGA3 is a transmembrane receptor that facilitates cell adhesion and signal transduction. It partners with beta subunits frequently beta 1 to form integrin complexes such as alpha3beta1. The mass of Integrin alpha 3b is about 113 kDa. This protein is mainly expressed in epithelial cells and keratinocytes where it aids in maintaining cell structure and communication with the extracellular matrix.

Biological function summary

Integrin alpha 3b plays an important role in cell-matrix interactions and intracellular signaling. It is part of the integrin family participating in the formation of focal adhesion complexes. These complexes facilitate the binding of cells to laminin and fibronectin essential for cell migration proliferation and differentiation. Additionally Integrin alpha 3b influences cell survival through its signaling pathways affecting processes like wound healing and tissue repair.

Pathways

Integrin alpha 3b contributes significantly to the MAPK and PI3K/AKT signaling pathways. These pathways are involved in cell growth and survival. The integrin signaling promotes interactions with proteins such as FAK and Src which are essential for transmitting signals from the extracellular environment to the interior of the cell. Through these interactions Integrin alpha 3b modulates cellular responses to external stimuli and regulates cytoskeletal dynamics.

Associated diseases and disorders

Integrin alpha 3b shows associations with cancer progression and fibrosis. In cancer abnormal expression or function of the ITGA3 gene can lead to increased metastasis and tumor invasiveness. Research suggests that interactions with proteins like MMP9 contribute to these pathogenic processes. In fibrosis the imbalance between cell adhesion and migration results in excessive tissue scarring where integrin signaling is disrupted. Understanding the role of Integrin alpha 3b in these conditions can offer insights into therapeutic interventions targeting these pathways.

Product promise

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