Mouse Monoclonal Integrin alpha 3 antibody. Suitable for ICC, WB, IHC-Fr and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Human Integrin alpha-3 conjugated to Keyhole Limpet Haemocyanin.
IgG1
Mouse
Preservative: 0.09% Sodium azide
Constituents: PBS
Liquid
Monoclonal
ICC | WB | IHC-Fr | |
---|---|---|---|
Human | Expected | Expected | Expected |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.(Microbial infection) Integrin ITGA3:ITGB1 may act as a receptor for R.delemar CotH7 in alveolar epithelial cells, which may be an early step in pulmonary mucormycosis disease progression.
MSK18, ITGA3, MSK18, Integrin alpha-3, CD49 antigen-like family member C, FRP-2, Galactoprotein B3, VLA-3 subunit alpha, GAPB3
Mouse Monoclonal Integrin alpha 3 antibody. Suitable for ICC, WB, IHC-Fr and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Human Integrin alpha-3 conjugated to Keyhole Limpet Haemocyanin.
IgG1
Mouse
Preservative: 0.09% Sodium azide
Constituents: PBS
Liquid
Monoclonal
54B3
Affinity purification Protein G
Recognizes specifically the cytoplasmic domain of integrin subunit a3B which is present in microvascular structures in brain and heart.
Cytoplasmic domain of a3B Integrin.
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
The integrins, finally, form a large family of glycosylated transmembrane proteins that act as dimers of an alpha and a beta subunit in interconnecting the cytoskeleton and the extracellular matrix.
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This supplementary information is collated from multiple sources and compiled automatically.
Integrin alpha 3b also known as ITGA3 is a transmembrane receptor that facilitates cell adhesion and signal transduction. It partners with beta subunits frequently beta 1 to form integrin complexes such as alpha3beta1. The mass of Integrin alpha 3b is about 113 kDa. This protein is mainly expressed in epithelial cells and keratinocytes where it aids in maintaining cell structure and communication with the extracellular matrix.
Integrin alpha 3b plays an important role in cell-matrix interactions and intracellular signaling. It is part of the integrin family participating in the formation of focal adhesion complexes. These complexes facilitate the binding of cells to laminin and fibronectin essential for cell migration proliferation and differentiation. Additionally Integrin alpha 3b influences cell survival through its signaling pathways affecting processes like wound healing and tissue repair.
Integrin alpha 3b contributes significantly to the MAPK and PI3K/AKT signaling pathways. These pathways are involved in cell growth and survival. The integrin signaling promotes interactions with proteins such as FAK and Src which are essential for transmitting signals from the extracellular environment to the interior of the cell. Through these interactions Integrin alpha 3b modulates cellular responses to external stimuli and regulates cytoskeletal dynamics.
Integrin alpha 3b shows associations with cancer progression and fibrosis. In cancer abnormal expression or function of the ITGA3 gene can lead to increased metastasis and tumor invasiveness. Research suggests that interactions with proteins like MMP9 contribute to these pathogenic processes. In fibrosis the imbalance between cell adhesion and migration results in excessive tissue scarring where integrin signaling is disrupted. Understanding the role of Integrin alpha 3b in these conditions can offer insights into therapeutic interventions targeting these pathways.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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