AB7166

Anti-Integrin alpha V beta 3 antibody [BV3]

Name: Anti-Integrin alpha V beta 3 antibody [BV3] (ab7166) | Abcam
Brand: Abcam Limited
SKU: AB7166
Price: 470 USD
Availability: InStock
Rating: 4 (11 reviews)

(11 Reviews)

(36 Publications)

Anti-Integrin alpha V beta 3 antibody [BV3] (ab7166) is a mouse monoclonal antibody detecting Integrin alpha V beta 3 in Flow Cytometry, IP, IHC-P, IHC-Fr, ICC/IF. Suitable for Chicken, Human, Rat.

- Over 20 publications
- Trusted since 2002

View Alternative Names

CD51, MSK8, VNRA, VTNR, ITGAV, Integrin alpha-V, Vitronectin receptor, Vitronectin receptor subunit alpha

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

BV3

Isotype

IgG1

Carrier free

Reacts with

Rat, Chicken, Human

Applications

ICC/IF, IP, IHC-Fr, Flow Cyt, IHC-P

applications

Specificity

This monoclonal antibody binds to human CD51 and Cd61 integrins present on human endothelium cells.

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Reactivity data

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Product details

What is this antibody validated in?
Anti-Integrin alpha V beta 3 antibody [BV3] (ab7166) is a mouse monoclonal antibody and is validated for use in Flow Cytometry (Flow Cyt), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunohistochemistry (IHC-Fr), Immunocytochemistry/immunofluorescence (ICC/IF) in Chicken, Human, Rat samples.

Trusted by the scientific community
Anti-Integrin alpha V beta 3 [BV3] (ab7166) was first used in a scientific publication in 2002 and has been cited over 20 times in peer-reviewed journals.

Reviewed by scientists
Anti-Integrin alpha V beta 3 [BV3] (ab7166) has over 5 independent reviews from customers.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Storage buffer

Preservative: 0.1% Sodium azide Constituents: 0.2% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Integrin alpha V beta 3 also known as integrin αvΒ3 or avb3 integrin is a transmembrane receptor with a molecular weight of about 140 kDa. This protein is composed of the alpha V (αv) and beta 3 (Β3) subunits. Integrin αvΒ3 is widely expressed in various cell types including endothelial cells osteoclasts and some tumor cells. Its function involves mechanical interaction with the extracellular matrix (ECM) allowing cells to adhere to ECM proteins such as vitronectin and fibronectin. This integrin plays an important role in cell adhesion migration and survival.

Biological function summary

Integrin alpha V beta 3 engages in various cellular processes by serving as a part of integrin complexes. It mediates signal transduction from the ECM to the cell interior influencing cellular responses such as shape changes survival and proliferation. The receptor regulates angiogenesis which is the formation of new blood vessels and osteoclast-mediated bone resorption. These functions are essential for tissue remodeling and repair. The integrin can also modulate immune responses by interacting with immune cells affecting inflammation and wound healing processes.

Pathways

Integrin alpha V beta 3 is an important component in signaling pathways such as the PI3K/AKT and MAPK pathways. These pathways facilitate the integrin's role in cell migration growth and survival. It interacts with proteins like focal adhesion kinase (FAK) and SRC kinase bridging signals from the ECM to intracellular signaling cascades. The integrin's ability to bind ligands and initiate these pathways makes it an important player in cellular responses to the extracellular environment influencing how cells align mechanically and biochemically.

Integrin alpha V beta 3 has significant associations with cancer progression and osteoporosis. In various cancers including melanoma and breast cancer overexpression of this integrin supports tumor angiogenesis and metastasis connecting its role with angiogenic growth factors and matrix metalloproteinases. In osteoporosis it collaborates with proteins like osteopontin promoting osteoclast attachment to the bone matrix thereby influencing bone degradation. Understanding its role in these disorders highlights potential therapeutic targets for inhibiting unwanted angiogenesis and excessive bone resorption.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV : ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed : 23125415). ITGAV : ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed : 20682778). ITGAV : ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed : 18441324). ITGAV : ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed : 28302677). ITGAV : ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed : 19578119). ITGAV : ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed : 28873464). ITGAV : ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed : 29030430). ITGAV : ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed : 18635536, PubMed : 25398877). ITGAV : ITGB3 and ITGAV : ITGB6 act as receptors for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (PubMed : 12807887, PubMed : 17158881). Integrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV : ITGB6 or ITGAV : ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed : 15184403, PubMed : 22278742, PubMed : 28117447). ITGAV : ITGB3 acts as a receptor for CD40LG (PubMed : 31331973). ITGAV : ITGB3 acts as a receptor for IBSP and promotes cell adhesion and migration to IBSP (PubMed : 10640428).. (Microbial infection) Integrin ITGAV : ITGB5 acts as a receptor for Adenovirus type C.. (Microbial infection) Integrin ITGAV : ITGB5 and ITGAV : ITGB3 act as receptors for Coxsackievirus A9 and B1.. (Microbial infection) Integrin ITGAV : ITGB3 acts as a receptor for Herpes virus 8/HHV-8.. (Microbial infection) Integrin ITGAV : ITGB6 acts as a receptor for herpes simplex 1/HHV-1.. (Microbial infection) Integrin ITGAV : ITGB3 acts as a receptor for Human parechovirus 1.. (Microbial infection) Integrin ITGAV : ITGB3 acts as a receptor for West nile virus.. (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

See full target information ITGAV

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Publications (36)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 25: PubMed39596225

2024

PKCα Activation via the Thyroid Hormone Membrane Receptor Is Key to Thyroid Cancer Growth.

Applications

Unspecified application

Species

Unspecified reactive species

Mateo N Campos Haedo,Johanna A Díaz Albuja,Sandra Camarero,Florencia Cayrol,Helena A Sterle,María M Debernardi,Marina Perona,Melina Saban,Glenda Ernst,Julián Mendez,María A Paulazo,Guillermo J Juvenal,María C Díaz Flaqué,Graciela A Cremaschi,Cinthia Rosemblit

iScience 27:110676 PubMed39262784

2024

Modulating the extracellular matrix to treat wound healing defects in Ehlers-Danlos syndrome.

Applications

Unspecified application

Species

Unspecified reactive species

Kindra M Kelly-Scumpia,Maani M Archang,Prabhat K Purbey,Tomohiro Yokota,Rimao Wu,Jackie McCourt,Shen Li,Rachelle H Crosbie,Philip O Scumpia,Arjun Deb

Journal of biomedical science 31:87 PubMed39237980

2024

Neuroprotective effects of intranasal extracellular vesicles from human platelet concentrates supernatants in traumatic brain injury and Parkinson's disease models.

Applications

Unspecified application

Species

Unspecified reactive species

Liling Delila,Ouada Nebie,Nhi Thao Ngoc Le,Kelly Timmerman,Deng-Yao Lee,Yu-Wen Wu,Ming-Li Chou,Luc Buée,Szu-Yi Chou,David Blum,David Devos,Thierry Burnouf

Drug delivery and translational research 14:2629-2641 PubMed38498080

2024

RGD-coated polymeric microbubbles promote ultrasound-mediated drug delivery in an inflamed endothelium-pericyte co-culture model of the blood-brain barrier.

Applications

Unspecified application

Species

Unspecified reactive species

Christopher Hark,Junlin Chen,Julia Blöck,Eva Miriam Buhl,Harald Radermacher,Robert Pola,Michal Pechar,Tomáš Etrych,Quim Peña,Anne Rix,Natascha I Drude,Fabian Kiessling,Twan Lammers,Jan-Niklas May

Oncology letters 27:14 PubMed38028179

2023

CBX7 is involved in the progression of cervical cancer through the ITGβ3/TGFβ1/AKT pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Ping Tian,Jinglan Deng,Cailing Ma,Ainipa Miershali,Gulikezi Maimaitirexiati,Qi Yan,Yating Liu,Hatimihan Maimaiti,Yuting Li,Changhui Zhou,Jingqin Ren,Lu Ding,Rong Li

Heliyon 9:e20185 PubMed37809806

2023

Fibronectin promotes tumor progression through integrin αvβ3/PI3K/AKT/SOX2 signaling in non-small cell lung cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jin-Long Wu,Cheng-Feng Xu,Xu-Hui Yang,Ming-Song Wang

International journal of molecular sciences 24: PubMed37108248

2023

Adhesion to the Brain Endothelium Selects Breast Cancer Cells with Brain Metastasis Potential.

Applications

Unspecified application

Species

Unspecified reactive species

Bai Zhang,Xueyi Li,Kai Tang,Ying Xin,Guanshuo Hu,Yufan Zheng,Keming Li,Cunyu Zhang,Youhua Tan

Ophthalmic research 66:144-150 PubMed36037800

2022

Expression of Osteopontin and Integrin αvβ3 Receptor in Retina of Diabetic Guinea Pigs with High Myopia.

Applications

Unspecified application

Species

Unspecified reactive species

Jinghong Dong,Lingfei Hu,Chenhao Li,Rongrong Zhang,Minmin Zheng,Xueji Wu,Changfan Wu

Drug delivery and translational research 13:1195-1211 PubMed35816231

2022

Profiling target engagement and cellular uptake of cRGD-decorated clinical-stage core-crosslinked polymeric micelles.

Applications

Unspecified application

Species

Unspecified reactive species

Federica De Lorenzi,Larissa Yokota Rizzo,Rasika Daware,Alessandro Motta,Maike Baues,Matthias Bartneck,Michael Vogt,Marc van Zandvoort,Leonard Kaps,Qizhi Hu,Marielle Thewissen,Luca Casettari,Cristianne J F Rijcken,Fabian Kiessling,Alexandros Marios Sofias,Twan Lammers

Bioactive materials 20:179-193 PubMed35663336

2022

A bioactive material with dual integrin-targeting ligands regulates specific endogenous cell adhesion and promotes vascularized bone regeneration in adult and fetal bone defects.

Applications

Unspecified application

Species

Unspecified reactive species

Dake Hao,Ruiwu Liu,Tomas Gonzalez Fernandez,Christopher Pivetti,Jordan Elizabeth Jackson,Edwin Samuel Kulubya,Hong-Jiang Jiang,Hai-Yang Ju,Wen-Liang Liu,Alyssa Panitch,Kit S Lam,J Kent Leach,Diana L Farmer,Aijun Wang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Integrin alpha V beta 3 antibody [BV3]

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Specificity

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Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (36)

Product promise