AB97588

Anti-Integrin alpha V + beta 6 antibody [avB6 53a.2]

Name: Anti-Integrin alpha V + beta 6 antibody [avB6 53a.2] (ab97588) | Abcam
Brand: Abcam Limited
SKU: AB97588
Price: 435 USD
Availability: InStock
Rating: 5 (2 reviews)

(2 Reviews)

(6 Publications)

Anti-Integrin alpha V + beta 6 antibody [avB6 53a.2] (ab97588) is a rat monoclonal antibody detecting Integrin alpha V + beta 6 in Flow Cytometry, ICC/IF, Neut. Suitable for Human.

- Trusted since 2010

View Alternative Names

CD51, MSK8, VNRA, VTNR, ITGAV, Integrin alpha-V, Vitronectin receptor, Vitronectin receptor subunit alpha

Key facts

Host species

Rat

Clonality

Monoclonal

Clone number

avB6 53a.2

Isotype

IgG2a

Carrier free

Reacts with

Human

Applications

Flow Cyt, ICC/IF, FuncS (Neut/Block)

applications

Immunogen

Full Length Protein corresponding to Human ITGAV. The exact immunogen used to generate this antibody is proprietary information.

P06756

Epitope

Extracelllular region of the heterodimer.

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Reactivity data

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Product details

What is this antibody validated in?
Anti-Integrin alpha V + beta 6 antibody [avB6 53a.2] (ab97588) is a rat monoclonal antibody and is validated for use in Flow Cytometry (Flow Cyt), Immunocytochemistry/immunofluorescence (ICC/IF), Neutralising in Human samples.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A/G

Storage buffer

Preservative: 0.02% Sodium azide Constituents: 99.98% PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Integrin αvΒ6 also known as integrin alpha V beta 6 or integrin avb6 is a protein that plays a significant role in cellular adhesion and signaling. This heterodimeric complex consists of alpha V and beta 6 subunits with a molecular weight around 150 kDa. Integrin αvΒ6 is primarily expressed in epithelial cells and remains largely absent in normal tissues but becomes upregulated in activated or injured epithelial tissues. Due to its limited expression under normal conditions integrin αvΒ6 presents a notable interest for research in tissue repair and related processes.

Biological function summary

Integrin αvΒ6 engages in binding with specific ligands such as fibronectin vitronectin and latency-associated peptides. This protein forms a part of a larger integrin family existing as a heterodimer playing an important role in the activation of transforming growth factor-beta (TGF-Β). The interaction between integrin αvΒ6 and its ligands contributes to cell proliferation migration differentiation and modulation of the local cellular environment affecting tissue remodeling and immunity.

Pathways

Integrin αvΒ6 is involved in TGF-Β signaling and the epithelial-mesenchymal transition (EMT) pathway. These pathways are fundamental for regulating developmental processes and tissue repair providing cues for cell fate and homeostasis. Additionally integrin αvΒ6 associates with other proteins including fibronectin and vitronectin enhancing its role in mediating cell-extracellular matrix interactions which supports cellular communication and migration essential for these pathways.

Integrin αvΒ6 has been implicated in conditions like fibrosis and cancer. Its involvement in promoting EMT and activating TGF-Β connects it closely with fibrotic diseases such as idiopathic pulmonary fibrosis where tissue scarring results from excessive collagen deposition. Regarding cancer integrin αvΒ6 expression is often increased in tumors and contributes to tumor progression and metastasis particularly in pancreatic cancer. Integrin αvΒ6 often collaborates with proteins like TGF-Β which actively participate in pathways facilitating these disease processes.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV : ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed : 23125415). ITGAV : ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed : 20682778). ITGAV : ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed : 18441324). ITGAV : ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed : 28302677). ITGAV : ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed : 19578119). ITGAV : ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed : 28873464). ITGAV : ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed : 29030430). ITGAV : ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed : 18635536, PubMed : 25398877). ITGAV : ITGB3 and ITGAV : ITGB6 act as receptors for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (PubMed : 12807887, PubMed : 17158881). Integrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV : ITGB6 or ITGAV : ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed : 15184403, PubMed : 22278742, PubMed : 28117447). ITGAV : ITGB3 acts as a receptor for CD40LG (PubMed : 31331973). ITGAV : ITGB3 acts as a receptor for IBSP and promotes cell adhesion and migration to IBSP (PubMed : 10640428).. (Microbial infection) Integrin ITGAV : ITGB5 acts as a receptor for Adenovirus type C.. (Microbial infection) Integrin ITGAV : ITGB5 and ITGAV : ITGB3 act as receptors for Coxsackievirus A9 and B1.. (Microbial infection) Integrin ITGAV : ITGB3 acts as a receptor for Herpes virus 8/HHV-8.. (Microbial infection) Integrin ITGAV : ITGB6 acts as a receptor for herpes simplex 1/HHV-1.. (Microbial infection) Integrin ITGAV : ITGB3 acts as a receptor for Human parechovirus 1.. (Microbial infection) Integrin ITGAV : ITGB3 acts as a receptor for West nile virus.. (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

See full target information ITGAV

Additional targets

Integrin beta-6,Integrin beta-6,Integrin beta-6

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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 11:8315 PubMed33859325

2021

Integrin αvβ5 heterodimer is a specific marker of human pancreatic beta cells.

Applications

Unspecified application

Species

Unspecified reactive species

Jacqueline V Schiesser,Thomas Loudovaris,Helen E Thomas,Andrew G Elefanty,Edouard G Stanley

Oncogene 39:2624-2637 PubMed32005976

2020

A role for CBFβ in maintaining the metastatic phenotype of breast cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Ran Ran,Hannah Harrison,Nur Syamimi Ariffin,Rahna Ayub,Henry J Pegg,Wensheng Deng,Andrea Mastro,Penny D Ottewell,Susan M Mason,Karen Blyth,Ingunn Holen,Paul Shore

Experimental and therapeutic medicine 14:3880-3886 PubMed29042996

2017

IL-32γ promotes integrin αvβ6 expression through the activation of NF-κB in HSCs.

Applications

Unspecified application

Species

Unspecified reactive species

Hongcan Liu,Xingfei Pan,Hong Cao,Xin Shu,Haixia Sun,Jianxi Lu,Jiayin Liang,Ka Zhang,Fengqin Zhu,Gang Li,Qi Zhang

Human gene therapy 23:960-79 PubMed22708837

2012

Combined fiber modifications both to target α(v)β(6) and detarget the coxsackievirus-adenovirus receptor improve virus toxicity profiles in vivo but fail to improve antitumoral efficacy relative to adenovirus serotype 5.

Applications

Flow Cyt

Species

Human

Lynda Coughlan,Sabari Vallath,Alena Gros,Marta Giménez-Alejandre,N Van Rooijen,Gareth J Thomas,Andrew H Baker,Manel Cascalló,Ramon Alemany,Ian R Hart

Cancer research 68:3295-303 PubMed18451156

2008

alpha vbeta 6 Integrin promotes the invasion of morphoeic basal cell carcinoma through stromal modulation.

Applications

Unspecified application

Species

Unspecified reactive species

Daniel Marsh,Sarah Dickinson,Graham W Neill,John F Marshall,Ian R Hart,Gareth J Thomas

Immunology 107:77-85 PubMed12225365

2002

Regulation of adhesion of AML14.3D10 cells by surface clustering of beta2-integrin caused by ERK-independent activation of cPLA2.

Applications

Unspecified application

Species

Unspecified reactive species

Shigeharu Myou,Xiangdong Zhu,Evan Boetticher,Yimin Qin,Saori Myo,Angelo Meliton,Anissa Lambertino,Nilda M Munoz,Kimm J Hamann,Alan R Leff

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Integrin alpha V + beta 6 antibody [avB6 53a.2]

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Epitope

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Additional targets

Publications (6)

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