Rabbit Polyclonal Integrin beta 5 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 29 publications.
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- Experimental and therapeutic medicine 26:5322023Integrin β5 is an independent prognostic marker for intrahepatic cholangiocarcinoma in a Chinese population.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLixing Ma,Kang Song,Jinfeng ZangPubMed 37869645
- Frontiers in endocrinology 11:6138792021SHCBP1 Promotes Papillary Thyroid Carcinoma Carcinogenesis and Progression Through Promoting Formation of Integrin and Collagen and Maintaining Cell Stemness.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHoufa Geng,Mengzhe Guo,Wei Xu,Xiu Zang,Tingting Wu,Fei Teng,Yu Wang,Xuekui Liu,Xiuli Wang,Qiang Sun,Jun LiangPubMed 33716952
- Journal of cellular and molecular medicine 24:996-10092019Irisin reverses intestinal epithelial barrier dysfunction during intestinal injury via binding to the integrin αVβ5 receptor.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJianbin Bi,Jia Zhang,Yifan Ren,Zhaoqing Du,Teng Li,Tao Wang,Lin Zhang,Mengzhou Wang,Zheng Wu,Yi Lv,Rongqian WuPubMed 31701659
- Frontiers in cellular neuroscience 12:4892018ROCK Inhibitor Y27632 Induced Morphological Shift and Enhanced Neurite Outgrowth-Promoting Property of Olfactory Ensheathing Cells via YAP-Dependent Up-Regulation of L1-CAM.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYijian Li et. al.PubMed 30618636
- Molecular microbiology 110:82-942018The Streptococcus agalactiae cell wall-anchored protein PbsP mediates adhesion to and invasion of epithelial cells by exploiting the host vitronectin/α integrin axis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGiuseppe Valerio De Gaetano et. al.PubMed 30030946
- Oncotarget 9:26130-261432018Heat shock protein 90 inhibitors augment endogenous wild-type p53 expression but down-regulate the adenovirally-induced expression by inhibiting a proteasome activity.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKuan Chai et. al.PubMed 29899847
- Journal of experimental & clinical cancer research 37:172018Integrin-β5, a miR-185-targeted gene, promotes hepatocellular carcinoma tumorigenesis by regulating β-catenin stability.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZhikun Lin et. al.PubMed 29386044
- Pharmacology research & perspectives 5:2017An integrin antagonist (MK-0429) decreases proteinuria and renal fibrosis in the ZSF1 rat diabetic nephropathy model.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiaoyan Zhou,Ji Zhang,Robin Haimbach,Wei Zhu,Rosemary Mayer-Ezell,Margarita Garcia-Calvo,Elizabeth Smith,Olga Price,Yanqing Kan,Emanuel Zycband,Yonghua Zhu,Maarten Hoek,Jason M Cox,Lijun Ma,David E Kelley,Shirly PintoPubMed 28971604
- Journal of cell science 130:3481-34952017The deubiquitylase USP10 regulates integrin β1 and β5 and fibrotic wound healing.Applications:Unspecified applicationReactive species:Unspecified reactive speciesStephanie R Gillespie et. al.PubMed 28851806
- Journal of the American Society of Nephrology : JA 28:1998-20052017Pharmacologic Blockade of v1 Integrin Ameliorates Renal Failure and Fibrosis .Applications:Unspecified applicationReactive species:Unspecified reactive speciesYongen Chang et. al.PubMed 28220032
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.6
Preservative: 0.1% Sodium azide
Constituents: PBS, 1% BSA- Form
Liquid
- Clonality
Polyclonal
Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
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Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
| Mouse | Predicted |
| Rat | Predicted |
| Hamster | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/50 | Notes Perform heat-mediated antigen retrieval before commencing with IHC staining protocol. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Hamster | Dilution info - | Notes - |
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3 products for Alternative Product
Target data
Function
Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.(Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C.
Alternative names
Integrin beta-5, ITGB5
Recommended products
Rabbit Polyclonal Integrin beta 5 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 29 publications.
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.6
Preservative: 0.1% Sodium azide
Constituents: PBS, 1% BSA- Form
Liquid
- Clonality
Polyclonal
- Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
- Purification technique
Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage duration
1-2 weeks
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
This product is FOR RESEARCH USE ONLY. For commercial use, please contact partnerships@abcam.com.
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Integrin beta 5 also known as integrin ß5 is a protein that plays an important role in cell adhesion and signal transduction. It is a component of the integrin family known to mediate interactions between cells and the extracellular matrix (ECM). This protein with a molecular mass of around 90 kDa is expressed in various tissues predominantly in epithelial cells. Integrin beta 5 partners with the alpha V subunit to form the alpha V beta 5 integrin complex which facilitates specific ligand binding such as to vitronectin.
- Biological function summary
Integrin beta 5 contributes to processes like cell migration proliferation and survival often occurring at cell surfaces. It is a part of the integrin complex which plays an important role in these cellular behaviors. Through its interaction with ECM proteins integrin beta 5 influences key biological activities and assists in maintaining tissue architecture. The activity of this integrin impacts how cells respond to their microenvironment influencing cellular fate decisions that are vital to growth and repair mechanisms.
- Pathways
Several signaling pathways involve integrin beta 5. It actively participates in the MAPK/ERK and PI3K/AKT pathways which are essential for transmitting signals that promote cell proliferation and survival. Additionally this integrin works closely with other proteins such as focal adhesion kinase (FAK) and Src family kinases integrating signals that modulate cellular responses to mechanical and biochemical cues from the ECM.
- Associated diseases and disorders
Integrin beta 5 shows involvement in cancer pathogenesis and fibrotic diseases. In cancer its expression correlates with processes such as tumor cell invasion and metastasis impacting prognosis in various cancers including lung and breast cancer. The protein is related to other integrins and ECM components like integrin alpha V and fibronectin contributing to tumor progression. Additionally in fibrotic diseases the dysregulation of integrin beta 5 influences the remodeling of the ECM linking to proteins such as transforming growth factor-beta (TGF-beta) to facilitate pathological tissue changes.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Integrin beta 5 antibody (ab15459)
Human small intestine (ab29276) stained with anti-Integrin beta 5 antibody, ab15459 by Immunohistochemistry (FFPE-sections).
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