JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB172007

Anti-Integrin beta 8 antibody

4

(1 Review)

|

(2 Publications)

Mouse Polyclonal Integrin beta 8 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Integrin beta-8.

View Alternative Names

Integrin beta-8, ITGB8

1 Images
Western blot - Anti-Integrin beta 8 antibody (AB172007)
  • WB

Supplier Data

Western blot - Anti-Integrin beta 8 antibody (AB172007)

All lanes:

Western blot - Anti-Integrin beta 8 antibody (ab172007) at 1 µg/mL

Lane 1:

ITGB8 transfected 293T lysate at 15 µL

Lane 2:

Non-transfected 293T lysate at 15 µL

Predicted band size: 86 kDa

true

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human Integrin beta-8.

P26012

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Integrin beta 8 also known as β8 integrin or ITGB8 is a transmembrane protein that functions mechanically as part of the integrin family. It forms heterodimers with the alpha v subunit resulting in the integrin alpha v beta 8 complex. This complex plays a role in cell adhesion and signaling by binding to extracellular matrix proteins like latency-associated peptide TGF-β. Integrin beta 8 is expressed in various tissues notably in the brain lungs and intestinal epithelium. The protein has a mass of approximately 85 kDa.
Biological function summary

Integrin beta 8 participates in the regulation of cellular processes such as growth differentiation and migration. The integrin alpha v beta 8 complex serves as a receptor for latent TGF-β activation an important step in modulating TGF-β signaling. This activation influences processes such as extracellular matrix remodeling and immune response regulation. Integrin beta 8 interacts with actin cytoskeleton regulatory proteins to mediate these cellular changes.

Pathways

Integrin beta 8 influences both TGF-β and Wnt signaling pathways. Its role in TGF-β pathway involves activation of latent TGF-β impacting tissue homeostasis and immune regulation. In connection to Wnt signaling integrin beta 8 modulates cell proliferation and differentiation. The protein shares functional relations with other integrins like integrin beta 6 which also interacts with similar ligands and pathways coordinating cellular response during development and repair processes.

Integrin beta 8 associates with conditions like brain tumors and fibrosis. For example its upregulation in glioblastoma multiforme contributes to the invasive properties of tumor cells by modulating TGF-β signaling similar to the role observed with integrin beta 6 in fibrotic diseases. This connection emphasizes the therapeutic potential of targeting integrin beta 8 to mitigate disease progression and improve treatment efficacy.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Integrin alpha-V : beta-8 (ITGAV : ITGB8) is a receptor for fibronectin (PubMed : 1918072). It recognizes the sequence R-G-D in its ligands (PubMed : 1918072). Integrin alpha-V : beta-6 (ITGAV : ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (Probable). Required during vasculogenesis (By similarity).
See full target information Integrin beta-8
style
left-column

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Open life sciences 16:667-681 PubMed34250246

2021

Long noncoding RNA HULC contributes to paclitaxel resistance in ovarian cancer via miR-137/ITGB8 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Bo Huang,Min Wei,Li Hong

PloS one 10:e0144187 PubMed26642205

2015

The Expression of miR-375 Is Associated with Carcinogenesis in Three Subtypes of Lung Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yi Jin,Yalan Liu,Jin Zhang,Wei Huang,Hongni Jiang,Yingyong Hou,Chen Xu,Changwen Zhai,Xue Gao,Shuyang Wang,Ying Wu,Hongguang Zhu,Shaohua Lu
View all publications
style
left-column
style
left-column
style
right-column

Alternative Products

Primary Antibodies

AB243023

Anti-Integrin beta 8 antibody [CL7290]

Immunocytochemistry/ Immunofluorescence - Anti-Integrin beta 8 antibody [CL7290] (AB243023)

  • 0
  • 0

Complementary Products

Primary Antibodies

AB179475

Anti-Integrin alpha V antibody [EPR16800]

RabMAb|Recombinant

Western blot - Anti-Integrin alpha V antibody [EPR16800] (AB179475)

  • 5
  • 10
Primary Antibodies

AB30394

Anti-Integrin beta 1 antibody [12G10]

KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-Integrin beta 1 antibody [12G10] (AB30394)

  • 5
  • 9
Secondary Antibodies

AB150113

Goat Anti-Mouse IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (AB150113)

  • 5
  • 15
Primary Antibodies

AB7817

Anti-alpha smooth muscle Actin antibody [1A4]

KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-alpha smooth muscle Actin antibody [1A4] (AB7817)

  • 5
  • 105

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com