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AB243023

Anti-Integrin beta 8 antibody [CL7290]

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(1 Publication)

Mouse Monoclonal Integrin beta 8 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Integrin beta-8 aa 550-700.

View Alternative Names

Integrin beta-8, ITGB8

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-Integrin beta 8 antibody [CL7290] (AB243023)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Integrin beta 8 antibody [CL7290] (AB243023)

Immunocytochemistry/Immunofluorescence analysis of WM-115 cells labeling Integrin beta 8 using ab243023 at 4 μg/ml (green). Nuclear probe is visualized in blue, microtubules in red.

Western blot - Anti-Integrin beta 8 antibody [CL7290] (AB243023)
  • WB

Supplier Data

Western blot - Anti-Integrin beta 8 antibody [CL7290] (AB243023)

All lanes:

Western blot - Anti-Integrin beta 8 antibody [CL7290] (ab243023) at 1 µg/mL

All lanes:

Human eye tissue lysate

Predicted band size: 86 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

CL7290

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

Recombinant Fragment Protein within Human Integrin beta-8 aa 550-700. The exact immunogen used to generate this antibody is proprietary information.

P26012

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "2-10 mg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100</p>" }, "Rabbit": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Purification notes
Purified from TCS.
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Integrin beta 8 also known as β8 integrin or ITGB8 is a transmembrane protein that functions mechanically as part of the integrin family. It forms heterodimers with the alpha v subunit resulting in the integrin alpha v beta 8 complex. This complex plays a role in cell adhesion and signaling by binding to extracellular matrix proteins like latency-associated peptide TGF-β. Integrin beta 8 is expressed in various tissues notably in the brain lungs and intestinal epithelium. The protein has a mass of approximately 85 kDa.
Biological function summary

Integrin beta 8 participates in the regulation of cellular processes such as growth differentiation and migration. The integrin alpha v beta 8 complex serves as a receptor for latent TGF-β activation an important step in modulating TGF-β signaling. This activation influences processes such as extracellular matrix remodeling and immune response regulation. Integrin beta 8 interacts with actin cytoskeleton regulatory proteins to mediate these cellular changes.

Pathways

Integrin beta 8 influences both TGF-β and Wnt signaling pathways. Its role in TGF-β pathway involves activation of latent TGF-β impacting tissue homeostasis and immune regulation. In connection to Wnt signaling integrin beta 8 modulates cell proliferation and differentiation. The protein shares functional relations with other integrins like integrin beta 6 which also interacts with similar ligands and pathways coordinating cellular response during development and repair processes.

Integrin beta 8 associates with conditions like brain tumors and fibrosis. For example its upregulation in glioblastoma multiforme contributes to the invasive properties of tumor cells by modulating TGF-β signaling similar to the role observed with integrin beta 6 in fibrotic diseases. This connection emphasizes the therapeutic potential of targeting integrin beta 8 to mitigate disease progression and improve treatment efficacy.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Integrin alpha-V : beta-8 (ITGAV : ITGB8) is a receptor for fibronectin (PubMed : 1918072). It recognizes the sequence R-G-D in its ligands (PubMed : 1918072). Integrin alpha-V : beta-6 (ITGAV : ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (Probable). Required during vasculogenesis (By similarity).
See full target information Integrin beta-8
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell death discovery 8:454 PubMed36371410

2022

LINC00472 inhibits cell migration by enhancing intercellular adhesion and regulates H3K27ac level via interacting with P300 in renal clear cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Songmao Wang,Cheng Luo,Bing Li,Shikuan Zhang,Weijie Liao,Qilei Xin,Naihan Xu,Weidong Xie,Yuanchang Zhu,Yaou Zhang
View all publications
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Product promise

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