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AB191903

Anti-Interferon alpha 1 antibody

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(5 Publications)

Rabbit Polyclonal Interferon alpha 1 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human IFNA1 aa 50-150.

View Alternative Names

IFNA13, IFNA1, Interferon alpha-1/13, IFN-alpha-1/13, Interferon alpha-D, LeIF D

1 Images
Western blot - Anti-Interferon alpha 1 antibody (AB191903)
  • WB

Supplier Data

Western blot - Anti-Interferon alpha 1 antibody (AB191903)

All lanes:

Western blot - Anti-Interferon alpha 1 antibody (ab191903)

Lane 1:

HEK-293T (Human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate

Lane 2:

NIH/3T3 (Mouse embryo fibroblast cell line) whole cell lysate

Lane 3:

H9c2 (Rat heart myoblast cell line) whole cell lysate

Predicted band size: 22 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human IFNA1 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.

P01562

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab191903 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Interferon alpha 1 (IFN-α1) is a type I interferon with significant antiviral and immunomodulatory activities. Alternate names include interferon alpha and IFNA1. This protein weighs approximately 19 kDa and expresses predominantly in leukocytes. It interacts with specific cell surface receptors to initiate various protective mechanisms in the cell. Researchers often study IFN-alpha-1 protein using techniques like interferon alpha ELISA and IFN-α ELISA for its effective quantification in experimental analyses.
Biological function summary

Interferon alpha 1 functions as an important player in the immune response against viral infections. It belongs to a family of cytokines that signal through the JAK-STAT pathway to induce the expression of interferon-stimulated genes (ISGs). IFN-α1 operates independently and does not form large complexes with other proteins ensuring a focused response to pathogens. This protein's role is critical for the initiation of immune responses and limiting the spread of viruses within the host organism.

Pathways

Interferon alpha 1 activates intracellular signaling cascades mainly the JAK-STAT pathway and NF-κB pathway. These pathways have important roles in cellular defense mechanisms. In the JAK-STAT pathway IFN-α1 interacts closely with other interferons and cytokines to enhance antiviral states. Through these pathways it shares functional relationships with proteins such as STAT1 and IRF7 which are critical for mounting effective antiviral defenses.

Interferon alpha 1 relates closely to conditions like hepatitis C and multiple sclerosis. It has therapeutic applications in these diseases due to its immunoregulatory effects. IFN-α1 interacts with various immune system components including major histocompatibility complex (MHC) proteins to modulate immune responses. Abnormalities in IFN-α1 signaling or expression can exacerbate inflammatory and autoimmune disorders linking it to both protective and pathological roles in human health.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes : a protein kinase and an oligoadenylate synthetase.
See full target information IFNA1
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Genes 14: PubMed37628607

2023

TRIM25 Suppresses Rabies Virus Fixed HEP-Flury Strain Production by Activating RIG-1-Mediated Type I Interferons.

Applications

Unspecified application

Species

Unspecified reactive species

Boyue Zhang,Ting Cai,Hongling He,Xuezhe Huang,Yongwen Luo,Shile Huang,Jun Luo,Xiaofeng Guo

International journal of molecular sciences 24: PubMed37446070

2023

TRIM21 Promotes Rabies Virus Production by Degrading IRF7 through Ubiquitination.

Applications

Unspecified application

Species

Unspecified reactive species

Boyue Zhang,Ting Cai,Hongling He,Xuezhe Huang,Guie Chen,Yanqin Lai,Yongwen Luo,Shile Huang,Jun Luo,Xiaofeng Guo

Biotechnology letters 43:1357-1369 PubMed33796959

2021

MiR-103/miR-107 inhibits enterovirus 71 replication and facilitates type I interferon response by regulating SOCS3/STAT3 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Baizhi Huang,Haiping Chen,Yanbing Zheng

Journal of cellular biochemistry 122:958-968 PubMed31773798

2019

Role of miR-106-mediated mitogen-activated protein kinase signaling pathway in oxidative stress injury and inflammatory infiltration in the liver of the mouse with gestational hypertension.

Applications

Unspecified application

Species

Unspecified reactive species

Zhihui Wang,Xiufang Bao,Limeng Song,Yuying Tian,Ping Sun

Advances in clinical and experimental medicine : official organ Wroclaw Medical University 27:165-171 PubMed29521058

2018

Splenectomy delays fracture healing by affecting the level of tumor necrosis factor alpha, interleukin 6 and bone morphogenetic protein.

Applications

Unspecified application

Species

Unspecified reactive species

Wanan Xiao,Xiaoxiao Yang,Yang Wang,Jianjun Li
View all publications
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