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AB20200

Anti-Interferon alpha 1 antibody [ST29]

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(3 Publications)

Mouse Monoclonal Interferon alpha 1 antibody. Suitable for sELISA and reacts with Recombinant full length protein - Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human IFNA1.

View Alternative Names

IFNA13, IFNA1, Interferon alpha-1/13, IFN-alpha-1/13, Interferon alpha-D, LeIF D

1 Images
Sandwich ELISA - Anti-Interferon alpha 1 antibody [ST29] (AB20200)
  • sELISA

Unknown

Sandwich ELISA - Anti-Interferon alpha 1 antibody [ST29] (AB20200)

Standard Curve for Interferon alpha (Analyte : ab48750) dilution range 1pg/ml to 1ug/ml using Capture Antibody Mouse monoclonal [ST29] to Interferon alpha (ab20200) at 5ug/ml and Detector Antibody Rabbit polyclonal to Interferon alpha (Biotin) (ab84257) at 0.5ug/ml.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

ST29

Isotype

IgG1

Light chain type

unknown

Carrier free

No

Applications

sELISA

applications

Immunogen

Recombinant Full Length Protein corresponding to Human IFNA1.

P01562

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Recombinant full length protein - Human": { "sELISA-species-checked": "testedAndGuaranteed", "sELISA-species-dilution-info": "5 µg/mL", "sELISA-species-notes": "<p></p>" } } }
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Product details

Myeloma: NS2
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A/G
Storage buffer
Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Interferon alpha 1 (IFN-α1) is a type I interferon with significant antiviral and immunomodulatory activities. Alternate names include interferon alpha and IFNA1. This protein weighs approximately 19 kDa and expresses predominantly in leukocytes. It interacts with specific cell surface receptors to initiate various protective mechanisms in the cell. Researchers often study IFN-alpha-1 protein using techniques like interferon alpha ELISA and IFN-α ELISA for its effective quantification in experimental analyses.
Biological function summary

Interferon alpha 1 functions as an important player in the immune response against viral infections. It belongs to a family of cytokines that signal through the JAK-STAT pathway to induce the expression of interferon-stimulated genes (ISGs). IFN-α1 operates independently and does not form large complexes with other proteins ensuring a focused response to pathogens. This protein's role is critical for the initiation of immune responses and limiting the spread of viruses within the host organism.

Pathways

Interferon alpha 1 activates intracellular signaling cascades mainly the JAK-STAT pathway and NF-κB pathway. These pathways have important roles in cellular defense mechanisms. In the JAK-STAT pathway IFN-α1 interacts closely with other interferons and cytokines to enhance antiviral states. Through these pathways it shares functional relationships with proteins such as STAT1 and IRF7 which are critical for mounting effective antiviral defenses.

Interferon alpha 1 relates closely to conditions like hepatitis C and multiple sclerosis. It has therapeutic applications in these diseases due to its immunoregulatory effects. IFN-α1 interacts with various immune system components including major histocompatibility complex (MHC) proteins to modulate immune responses. Abnormalities in IFN-α1 signaling or expression can exacerbate inflammatory and autoimmune disorders linking it to both protective and pathological roles in human health.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes : a protein kinase and an oligoadenylate synthetase.
See full target information IFNA1
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Infectious diseases and therapy 13:2053-2070 PubMed39097549

2024

Safety, Tolerability, and Pharmacokinetics of Nebulized GB05-Human IFNα1b Inhalation Solution: A Randomized, Placebo-Controlled, Dose-Escalation Phase I Study in Healthy Chinese Adult Volunteers.

Applications

Unspecified application

Species

Unspecified reactive species

Hengxin Peng,Wenjun Zhang,Yanqing Lin,Huiming Li,Suofu Qin

Integrative biology : quantitative biosciences from nano to macro 9:857-867 PubMed29098213

2017

Single-cell analysis of early antiviral gene expression reveals a determinant of stochastic IFNB1 expression.

Applications

Unspecified application

Species

Unspecified reactive species

Sultan Doğanay,Maurice Youzong Lee,Alina Baum,Jessie Peh,Sun-Young Hwang,Joo-Yeon Yoo,Paul J Hergenrother,Adolfo García-Sastre,Sua Myong,Taekjip Ha

Journal of immunology (Baltimore, Md. : 1950) 133:3096-101 PubMed6491281

1984

Monoclonal antibodies that distinguish between subspecies of human interferon-alpha and that detect interferon oligomers.

Applications

Unspecified application

Species

Unspecified reactive species

M Shearer,J Taylor-Papadimitriou,D Griffin,F Balkwill
View all publications
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Product promise

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