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AB87900

Anti-Interferon alpha 2b antibody [24B10]

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(1 Publication)

Mouse Monoclonal Interferon alpha 2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.

View Alternative Names

IFNA2A, IFNA2B, IFNA2C, IFNA2, Interferon alpha-2, IFN-alpha-2, Interferon alpha-A, LeIF A

3 Images
Western blot - Anti-Interferon alpha 2b antibody [24B10] (AB87900)
  • WB

Unknown

Western blot - Anti-Interferon alpha 2b antibody [24B10] (AB87900)

All lanes:

Western blot - Anti-Interferon alpha 2b antibody [24B10] (ab87900) at 5 µg/mL

All lanes:

Western blot - Recombinant Human Interferon alpha 2b protein (<a href='/en-us/products/proteins-peptides/recombinant-human-interferon-alpha-2b-protein-ab51094'>ab51094</a>) at 0.01 µg

Secondary

All lanes:

Western blot - Goat Anti-Mouse IgG H&L (HRP) preadsorbed (<a href='/en-us/products/secondary-antibodies/goat-mouse-igg-h-l-hrp-preadsorbed-ab97040'>ab97040</a>) at 1/5000 dilution

Predicted band size: 22 kDa

true

Exposure time: 1min

Western blot - Anti-Interferon alpha 2b antibody [24B10] (AB87900)
  • WB

Unknown

Western blot - Anti-Interferon alpha 2b antibody [24B10] (AB87900)

All lanes:

Western blot - Anti-Interferon alpha 2b antibody [24B10] (ab87900) at 5 µg/mL

All lanes:

Western blot - Recombinant Human Interferon alpha 2b protein (<a href='/en-us/products/proteins-peptides/recombinant-human-interferon-alpha-2b-protein-ab51094'>ab51094</a>) at 0.01 µg

Secondary

All lanes:

Western blot - Goat Anti-Mouse IgG H&L (HRP) preadsorbed (<a href='/en-us/products/secondary-antibodies/goat-mouse-igg-h-l-hrp-preadsorbed-ab97040'>ab97040</a>) at 1/5000 dilution

Predicted band size: 22 kDa

true

Exposure time: 1min

Western blot - Anti-Interferon alpha 2b antibody [24B10] (AB87900)
  • WB

Ap1002480****

Western blot - Anti-Interferon alpha 2b antibody [24B10] (AB87900)

All lanes:

Western blot - Anti-Interferon alpha 2b antibody [24B10] (ab87900) at 5 µg/mL

All lanes:

HeLa expressing Interferon alpha 2b recombinant protein. at 10 µg

Secondary

All lanes:

Western blot - Goat Anti-Mouse IgG H&L (HRP) preadsorbed (<a href='/en-us/products/secondary-antibodies/goat-mouse-igg-h-l-hrp-preadsorbed-ab97040'>ab97040</a>) at 1/5000 dilution

Predicted band size: 22 kDa

Observed band size: 21 kDa

true

Exposure time: 3min

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

24B10

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "5 µg/mL", "WB-species-notes": "<p></p>" } } }
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Product details

Want a custom formulation?
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com
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Properties and storage information

Form
Liquid
Purity
IgG fraction
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Interferon alpha 2b also known as IFN-alpha 2b or alpha 2b interferon is a type I interferon protein with an average molecular weight of approximately 19000 Daltons. The protein plays a role in the immune response by exhibiting antiviral antiproliferative and immunomodulatory activities. It is expressed mainly in leukocytes such as lymphocytes macrophages and dendritic cells. Researchers can buy interferon online for laboratory uses or create custom alpha 2b interferon for specific research needs.
Biological function summary

Interferon alpha 2b stimulates the immune system to attack pathogens by enhancing antigen presentation and activating natural killer cells and macrophages. It does not function as part of a complex and it acts independently to initiate an antiviral state in cells and increase the host's defense mechanisms. Its role in regulating cell growth and differentiation adds to its importance in maintaining immune homeostasis.

Pathways

Interferon alpha 2b is involved in the JAK-STAT signaling pathway which induces transcription of interferon-stimulated genes that orchestrate an immune response. Additionally it plays a role in the interferon signaling pathway which contributes to innate immunity. Proteins related to it through these pathways include STAT1 and STAT2 which collaborate with IFN alpha-b protein to transmit signals from extracellular stimuli to the nucleus resulting in gene activation.

Interferon alpha 2b is associated with chronic hepatitis C and certain types of cancer including melanoma. It engages with viral proteins in hepatitis C aiming to clear the virus and reduce liver damage. In cancer the antiproliferative properties of interferon alpha 2b help to inhibit tumor cell growth. In these contexts it connects with proteins such as PKR which helps mediate antiviral and anti-tumor responses.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Produced by macrophages, IFN-alpha have antiviral activities.
See full target information IFNA2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell death & disease 6:e1763 PubMed25973683

2015

XBP1 mitigates aminoglycoside-induced endoplasmic reticulum stress and neuronal cell death.

Applications

Unspecified application

Species

Unspecified reactive species

N Oishi,S Duscha,H Boukari,M Meyer,J Xie,G Wei,T Schrepfer,B Roschitzki,E C Boettger,J Schacht
View all publications
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