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AB9388

Anti-Interferon alpha 2b antibody [4E10]

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(1 Publication)

Anti-Interferon alpha 2b antibody [4E10] (ab9388) is a mouse monoclonal antibody detecting Interferon alpha 2b in Western Blot. Suitable for Human.

- Trusted since 2002

View Alternative Names

IFNA2A, IFNA2B, IFNA2C, IFNA2, Interferon alpha-2, IFN-alpha-2, Interferon alpha-A, LeIF A

1 Images
Western blot - Anti-Interferon alpha 2b antibody [4E10] (AB9388)
  • WB

Unknown

Western blot - Anti-Interferon alpha 2b antibody [4E10] (AB9388)

Immunoblot of human interferon alpha 2b using monoclonal antibody 4E10 at a dilution of 1 : 500 (4 μg/ml).
Lane 1 - interferon alpha 2b
Lane 2 - prestained standard proteins.

Immunoblot of human interferon alpha 2b using monoclonal antibody 4E10 at a dilution of 1 : 500 (4 μg/ml).
Lane 1 - interferon alpha 2b
Lane 2 - prestained standard proteins.

All lanes:

Western blot - Anti-Interferon alpha 2b antibody [4E10] (ab9388)

Predicted band size: 22 kDa

false

  • HRP

    HRP Anti-Interferon alpha 2b antibody [4E10]

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

4E10

Isotype

IgG1

Light chain type

unknown

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human IFNA2.

P01563

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "<p></p>" } } }
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Product details

Anti-Interferon alpha 2b antibody [4E10] (ab9388) is a mouse monoclonal antibody and is validated for use in WB.

Abcam's high quality validation processes ensure Anti-Interferon alpha 2b antibody [4E10] (ab9388) has high sensitivity and specificity.

Anti-Interferon alpha 2b antibody [4E10] (ab9388) specifically detects Interferon alpha 2b (UniProt ID: P01563; Molecular weight: 22kDa) and is sold in 100 µL selling sizes.

Antibody clone 4E10 is also available pre-conjugated to a variety of labels for your convenience - HRP (ab5258).

Interferon alpha 2b helps the immune system fight viral infections and certain cancers by enhancing the body's natural defense mechanisms. Interferon alpha 2b has been implicated in hepatitus B and C, lymphoma and malignant melanoma
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Interferon alpha 2b also known as IFN-alpha 2b or alpha 2b interferon is a type I interferon protein with an average molecular weight of approximately 19000 Daltons. The protein plays a role in the immune response by exhibiting antiviral antiproliferative and immunomodulatory activities. It is expressed mainly in leukocytes such as lymphocytes macrophages and dendritic cells. Researchers can buy interferon online for laboratory uses or create custom alpha 2b interferon for specific research needs.
Biological function summary

Interferon alpha 2b stimulates the immune system to attack pathogens by enhancing antigen presentation and activating natural killer cells and macrophages. It does not function as part of a complex and it acts independently to initiate an antiviral state in cells and increase the host's defense mechanisms. Its role in regulating cell growth and differentiation adds to its importance in maintaining immune homeostasis.

Pathways

Interferon alpha 2b is involved in the JAK-STAT signaling pathway which induces transcription of interferon-stimulated genes that orchestrate an immune response. Additionally it plays a role in the interferon signaling pathway which contributes to innate immunity. Proteins related to it through these pathways include STAT1 and STAT2 which collaborate with IFN alpha-b protein to transmit signals from extracellular stimuli to the nucleus resulting in gene activation.

Interferon alpha 2b is associated with chronic hepatitis C and certain types of cancer including melanoma. It engages with viral proteins in hepatitis C aiming to clear the virus and reduce liver damage. In cancer the antiproliferative properties of interferon alpha 2b help to inhibit tumor cell growth. In these contexts it connects with proteins such as PKR which helps mediate antiviral and anti-tumor responses.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Produced by macrophages, IFN-alpha have antiviral activities.
See full target information IFNA2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature cell biology 8:46-54 PubMed16341206

2005

Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells.

Applications

Unspecified application

Species

Unspecified reactive species

Oleg O Glebov,Nicholas A Bright,Benjamin J Nichols
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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