Rabbit Polyclonal Interferon alpha/beta receptor 1 antibody. Suitable for IF, IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human IFNAR1.
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- American journal of translational research 13:12094-121062021Efficient mutagenesis targeting the gene in mice using a combination of Cas9 protein and dual gRNAs.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZhihui Liu,Zongxiang Chen,Jingya Di,Zhisong Wang,Yongxia Zhang,Jinshan Li,Liyou An,Giorgio Antonio Presicce,Lanjun Liu,Fuliang DuPubMed 34786147
- Journal of translational medicine 19:172021A monocentric phase I study of vemurafenib plus cobimetinib plus PEG-interferon (VEMUPLINT) in advanced melanoma patients harboring the V600BRAF mutation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesEster Simeone,Giosuè Scognamiglio,Mariaelena Capone,Diana Giannarelli,Antonio M Grimaldi,Domenico Mallardo,Gabriele Madonna,Marcello Curvietto,Assunta Esposito,Fabio Sandomenico,Francesco Sabbatino,Nicholas L Bayless,Sarah Warren,SuFey Ong,Gerardo Botti,Keith T Flaherty,Soldano Ferrone,Paolo A AsciertoPubMed 33407577
- Scientific reports 10:67402020Cochlear supporting cells function as macrophage-like cells and protect audiosensory receptor hair cells from pathogens.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYushi Hayashi et. al.PubMed 32317718
- Arthritis & rheumatology (Hoboken, N.J.) 71:133-1422018Salivary Gland Stem Cells Age Prematurely in Primary Sjögren's Syndrome.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSarah Pringle,Xiaoyan Wang,Gwenny M P J Verstappen,Janneke H Terpstra,Clarence K Zhang,Aiqing He,Vishal Patel,Rhiannon E Jones,Duncan M Baird,Fred K L Spijkervet,Arjan Vissink,Hendrika Bootsma,Robert P Coppes,Frans G M KroesePubMed 29984480
- Stem cells and development 20:709-192010Efficacy assessment of interferon-alpha-engineered mesenchymal stromal cells in a mouse plasmacytoma model.Applications:IHC-FrReactive species:MouseSilvia Sartoris,Marta Mazzocco,Martina Tinelli,Matteo Martini,Federico Mosna,Veronica Lisi,Stefano Indraccolo,Lidia Moserle,Tiziana Cestari,Anna Pia Riviera,Francesco Bifari,Giuseppe Tridente,Giovanni Pizzolo,Mauro KramperaPubMed 20695752
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human IFNAR1. The exact immunogen used to generate this antibody is proprietary information. Database link P17181
Reactivity data
Select an application| IF | IHC-P | |
|---|---|---|
| Human | Tested | Tested |
IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100.00000 - 1/500.00000 | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/50.00000 - 1/100.00000 | Notes - |
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Target data
Function
Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa) (PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:2153461, PubMed:21854986, PubMed:24075985, PubMed:31270247, PubMed:33252644, PubMed:35442418, PubMed:7813427). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response (PubMed:10049744, PubMed:21854986, PubMed:7665574). Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another (PubMed:21854986, PubMed:32972995, PubMed:7665574, PubMed:7813427). The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors (PubMed:21854986, PubMed:32972995, PubMed:7526154, PubMed:7665574, PubMed:7813427). STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes (PubMed:19561067, PubMed:21854986, PubMed:32972995, PubMed:7665574, PubMed:7813427, PubMed:9121453). Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).
Alternative names
IFNAR, IFNAR1, Interferon alpha/beta receptor 1, IFN-R-1, IFN-alpha/beta receptor 1, Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1, Type I interferon receptor 1, CRF2-1
Recommended products
Rabbit Polyclonal Interferon alpha/beta receptor 1 antibody. Suitable for IF, IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human IFNAR1.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human IFNAR1. The exact immunogen used to generate this antibody is proprietary information. Database link P17181
- Purification technique
- Affinity purification Immunogen
- Concentration
- Purification notes
ab62693 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Stable for 12 months at -20°C
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Interferon alpha/beta receptor 1 also known as IFNAR1 is an important component of the interferon receptor complex which includes the interferon beta receptor (IFNBR) and the broader class of interferon receptors. IFNAR1 is a transmembrane protein with a molecular mass of approximately 100 kDa. It shows expression in various tissues but predominantly in cells of the immune system. This expression pattern enables IFNAR1 to play a central role in mediating responses to interferon alpha and beta which are cytokines important in the immune response.
- Biological function summary
IFNAR1 partners with interferon alpha receptor 2 (IFNAR2) to form a functional receptor complex. This complex binds interferons alpha and beta triggering signal transduction cascades vital for antiviral defense. Through this interaction IFNAR1 facilitates cellular immune responses including the activation of antiviral genes and modulation of cell proliferation. IFNAR1's role extends beyond immediate immune response influencing processes like cell differentiation and apoptosis.
- Pathways
IFNAR1 is a participant in the JAK-STAT signaling pathway a significant pathway for transmitting cytokine signals. Upon interferon binding it activates the associated Janus kinases (JAKs) which in turn phosphorylate signal transducers and activators of transcription (STATs) specifically STAT1 and STAT2. This chain of events results in the transcription of interferon-stimulated genes that provide antiviral defenses and promote immune regulation. IFNAR1's engagement in these pathways makes it an integral part of immune system communication.
- Associated diseases and disorders
IFNAR1 associates strongly with autoimmune diseases and viral infections. In lupus an autoimmune disorder dysregulation in interferon signaling involving IFNAR1 contributes to disease progression. Moreover in viral infections like hepatitis C the response of IFNAR1 to interferon therapies can influence treatment outcomes. Understanding these connections facilitates therapeutic strategies that target interferon pathways for improved disease management.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Immunofluorescence - Anti-Interferon alpha/beta receptor 1 antibody (ab62693)
Immunofluorescent analysis of HepG2 cells labeling interferon alpha/beta receptor with ab62693. The image on the right is blocked with the synthesized peptide prior to imunnoflurescent labeling.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Interferon alpha/beta receptor 1 antibody (ab62693)
ab62693 at 1/50 dilution staining Interferon alpha/beta receptor 1 in human brain by Immunohistochemistry, Paraffin-embedded tissue, in the absence or presence of the immunising peptide.
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