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AB168413

Anti-Interferon alpha10 antibody

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(1 Publication)

Rabbit Polyclonal Interferon alpha10 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human IFNA10.

View Alternative Names

Interferon alpha-10, IFN-alpha-10, Interferon alpha-6L, Interferon alpha-C, LeIF C, IFNA10

1 Images
Western blot - Anti-Interferon alpha10 antibody (AB168413)
  • WB

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Western blot - Anti-Interferon alpha10 antibody (AB168413)

All lanes:

Western blot - Anti-Interferon alpha10 antibody (ab168413) at 1 µg/mL

Lane 1:

Interferon alpha10 transfected 293T cell line lysate

Lane 2:

Non-transfected 293T cell line lysate

Predicted band size: 22 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human IFNA10.

P01566

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Interferon alpha10 also known as IFN-α10 is a protein belonging to the type I interferon family. It has a molecular mass of approximately 20 kDa. This protein is known for its role in immune response and is expressed in various cell types including lymphocytes and dendritic cells. IFN-α10 functions as a cytokine meaning it is important for communication between cells to initiate and regulate the defense against pathogens.
Biological function summary

IFN-α10 plays an important role in antiviral defense immune surveillance and modulation of the immune response. This cytokine can interfere with viral replication processes within host cells assisting the body's natural defenses in controlling viral infections. IFN-α10 is part of the cytokine signaling complex engaging with cell surface receptors to initiate the JAK-STAT signaling pathway. This induces the expression of genes responsible for antiviral activities and immune modulation.

Pathways

IFN-α10 engages in the JAK-STAT pathway and this influences cell survival cell proliferation and apoptosis. It interacts with other proteins like STAT1 and STAT2 which are critical for transmitting signals from cytokine receptors to the cell nucleus. IFN-α10 is also involved in the antiviral pathway working in conjunction with other interferons such as IFN-β to enhance the immune system's ability to combat viral infections.

IFN-α10 has links to conditions such as viral hepatitis and systemic lupus erythematosus (SLE). In the context of viral hepatitis IFN-α10's anti-viral actions help to control viral replication within the liver. In SLE there is often an upregulation of type I interferons including IFN-α10 which can contribute to disease pathogenesis by affecting immune regulation. IFN-α10 connects to other interferons such as IFN-α2 within these diseases both of which play roles in moderating immune responses and influencing disease progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes : a protein kinase and an oligoadenylate synthetase.
See full target information IFNA10
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of biological chemistry 300:107783 PubMed39303913

2024

Downregulation of the mA reader YTHDC2 upregulates exosome content in lung adenocarcinoma via inhibiting IFIT and OAS family members.

Applications

Unspecified application

Species

Unspecified reactive species

Zhixin Yin,Lifang Ma,Xiaoting Tian,Qi Sun,Congcong Zhang,Yikun Wang,Yayou Miao,Xiangfei Xue,Yongjie Wang,Jiayi Wang,Xiao Zhang,Xumin Hou
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Product promise

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