AB224765

Anti-INTS11 antibody

Name: Anti-INTS11 antibody (ab224765) | Abcam
Brand: Abcam Limited
SKU: AB224765
Price: 645 USD
Availability: InStock

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(1 Publication)

Rabbit Polyclonal INTS11 antibody. Suitable for IHC-P and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human INTS11 aa 400-500.

View Alternative Names

CPSF3L, RC68, INTS11, Integrator complex subunit 11, Int11, Cleavage and polyadenylation-specific factor 3-like protein, Protein related to CPSF subunits of 68 kDa, CPSF3-like protein, RC-68

4 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-INTS11 antibody (AB224765)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-INTS11 antibody (AB224765)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human placenta tissue labeling INTS11 with ab224765 at a 1/200 dilution.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-INTS11 antibody (AB224765)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human uterine cervix tissue labeling INTS11 with ab224765 at a 1/200 dilution.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-INTS11 antibody (AB224765)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human testis tissue labeling INTS11 with ab224765 at a 1/200 dilution.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-INTS11 antibody (AB224765)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human stomach tissue labeling INTS11 with ab224765 at a 1/200 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Rat, Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human INTS11 aa 400-500. The exact immunogen used to generate this antibody is proprietary information.

Q5TA45

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": " Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": " Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Rat": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": " Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

INTS11 also known as Integrator Complex Subunit 11 is an important component of the integrator complex involved in transcriptional regulation. It weighs approximately 52 kDa. INTS11 shows expression in various tissues with higher levels in testis brain and skeletal muscle. It acts as a subunit of the Integrator complex playing a role in the processing of small nuclear RNA (snRNA).

Biological function summary

The integrator complex containing INTS11 associates with the C-terminal domain of RNA polymerase II. This connection suggests its role in RNA processing events. INTS11 in collaboration with other subunits like INTS9 contributes to the cleavage and 3'-end processing of nascent snRNAs. The accurate processing of snRNA is essential for proper spliceosome formation and function impacting overall RNA maturation.

Pathways

INTS11 participates in RNA splicing and processing related pathways including the major spliceosomal pathway. It forms a vital axis with INTS9 another integrator complex subunit to assist in proper RNA transcription termination and processing. Its activity intersects with RNA polymerase II emphasizing its influence on RNA biosynthesis and turnover.

Mutations and dysregulation in INTS11 have been linked to neurological disorders and certain cancers. Disruption in its expression or function can lead to faulty RNA processing and splicing highlighting its impact on cellular homeostasis. Additionally INTS11 shows interaction with proteins like cyclin-dependent kinase CDK8 suggesting its regulatory effects on cell cycle and transcriptional control.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

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Target data

Catalytic component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed : 23904267).

See full target information INTS11

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

DNA repair 95:102946 PubMed32853826

2020

C17orf53 is identified as a novel gene involved in inter-strand crosslink repair.

Applications

Unspecified application

Species

Unspecified reactive species

Chao Wang,Zhen Chen,Dan Su,Mengfan Tang,Litong Nie,Huimin Zhang,Xu Feng,Rui Wang,Xi Shen,Mrinal Srivastava,Megan E McLaughlin,Traver Hart,Lei Li,Junjie Chen

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-INTS11 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-INTS11 antibody (AB224765)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-INTS11 antibody (AB224765)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-INTS11 antibody (AB224765)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-INTS11 antibody (AB224765)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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