Rabbit Polyclonal INTS11 antibody. Suitable for IHC-P and reacts with Human, Mouse, Rat samples. Immunogen corresponding to Recombinant Fragment Protein within Human INTS11 aa 400-500.
Images
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
Liquid
- Clonality
Polyclonal
Immunogen
- Recombinant Fragment Protein within Human INTS11 aa 400-500. The exact immunogen used to generate this antibody is proprietary information. Database link Q5TA45
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
| Mouse | Expected |
| Rat | Expected |
| Cow | Predicted |
| Orangutan | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/50.00000 - 1/200.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/50.00000 - 1/200.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Species Rat | Dilution info 1/50.00000 - 1/200.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Cow, Orangutan | Dilution info - | Notes - |
Associated Products
Select an associated product type
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Target data
Function
Catalytic component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).
Alternative names
Integrator complex subunit 11, Int11, Cleavage and polyadenylation-specific factor 3-like protein, Protein related to CPSF subunits of 68 kDa, CPSF3-like protein, RC-68, CPSF3L, RC68, INTS11
Recommended products
Rabbit Polyclonal INTS11 antibody. Suitable for IHC-P and reacts with Human, Mouse, Rat samples. Immunogen corresponding to Recombinant Fragment Protein within Human INTS11 aa 400-500.
Alternative names
Integrator complex subunit 11, Int11, Cleavage and polyadenylation-specific factor 3-like protein, Protein related to CPSF subunits of 68 kDa, CPSF3-like protein, RC-68, CPSF3L, RC68, INTS11
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
Liquid
- Clonality
Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human INTS11 aa 400-500. The exact immunogen used to generate this antibody is proprietary information. Database link Q5TA45
- Purification technique
Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage duration
1-2 weeks
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
INTS11 also known as Integrator Complex Subunit 11 is an important component of the integrator complex involved in transcriptional regulation. It weighs approximately 52 kDa. INTS11 shows expression in various tissues with higher levels in testis brain and skeletal muscle. It acts as a subunit of the Integrator complex playing a role in the processing of small nuclear RNA (snRNA).
- Biological function summary
The integrator complex containing INTS11 associates with the C-terminal domain of RNA polymerase II. This connection suggests its role in RNA processing events. INTS11 in collaboration with other subunits like INTS9 contributes to the cleavage and 3'-end processing of nascent snRNAs. The accurate processing of snRNA is essential for proper spliceosome formation and function impacting overall RNA maturation.
- Pathways
INTS11 participates in RNA splicing and processing related pathways including the major spliceosomal pathway. It forms a vital axis with INTS9 another integrator complex subunit to assist in proper RNA transcription termination and processing. Its activity intersects with RNA polymerase II emphasizing its influence on RNA biosynthesis and turnover.
- Associated diseases and disorders
Mutations and dysregulation in INTS11 have been linked to neurological disorders and certain cancers. Disruption in its expression or function can lead to faulty RNA processing and splicing highlighting its impact on cellular homeostasis. Additionally INTS11 shows interaction with proteins like cyclin-dependent kinase CDK8 suggesting its regulatory effects on cell cycle and transcriptional control.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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4 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-INTS11 antibody (ab224765)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded human testis tissue labeling INTS11 with ab224765 at a 1/200 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-INTS11 antibody (ab224765)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded human uterine cervix tissue labeling INTS11 with ab224765 at a 1/200 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-INTS11 antibody (ab224765)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded human placenta tissue labeling INTS11 with ab224765 at a 1/200 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-INTS11 antibody (ab224765)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded human stomach tissue labeling INTS11 with ab224765 at a 1/200 dilution.
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