Anti-Involucrin antibody [IVRN/2113R]
- Recombinant
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(1 Publication)
Rabbit Recombinant Monoclonal Involucrin antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human IVL.
View Alternative Names
Involucrin, IVL
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Involucrin antibody [IVRN/2113R] (AB234403)
Formalin-fixed, paraffin-embedded human tonsil tissue stained for Involucrin with ab234403 in immunohistochemical analysis.
Reactivity data
Properties and storage information
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Purification notes
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Appropriate short-term storage conditions
Appropriate long-term storage conditions
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Supplementary information
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Biological function summary
Involucrin serves as a critical substrate in the formation of the CCE by providing reactive sites for cross-linking with other proteins like loricrin and small proline-rich proteins. This cross-linking process occurs due to the action of transglutaminases which bond glutamine residues of involucrin with lysine residues in other proteins reinforcing the skin's protective barrier. Involucrin is a part of the protein network integral to keratinocyte terminal differentiation playing a distinctive role in the formation of a resilient and impermeable skin surface.
Pathways
Involucrin contributes directly within the epidermal differentiation complex (EDC) supporting the skin barrier's structural stability and resilience. The protein prominently acts in the terminal differentiation pathway in conjunction with other structural proteins such as filaggrin and keratins. This pathway forms a protective barrier that resists mechanical stress and environmental insults functioning together to provide a robust defense against external factors.
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Target data
Publications (1)
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Oncology letters 28:468 PubMed39119236
2024
Applications
Unspecified application
Species
Unspecified reactive species
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