Anti-IP-10 antibody [RP23040081]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

IP-10 also known as CXCL10 is a chemokine with a molecular weight of approximately 8.7 kDa. It functions by binding to the CXCR3 receptor a process that regulates immune responses. IP-10 is expressed in a variety of cells such as monocytes epithelial cells and fibroblasts particularly during inflammatory states. Its expression occurs in response to interferons especially IFN-γ indicating its role in immune system activity.

Biological function summary

The protein functions in the recruitment of immune cells like activated T-cells and NK cells to sites of inflammation or infection. It acts independently and is not known to be part of a larger protein complex. IP-10 plays an important role in promoting inflammation thereby contributing to the host defense mechanisms against microbial pathogens. It participates actively in immune surveillance and responses to various pathogens by attracting the immune cells to where they are needed.

Pathways

The chemokine is integral to the inflammatory response and cellular immune response pathways. Throughout these pathways IP-10 operates alongside various cytokines and chemokines such as CXCL9 and CXCL11 which also bind to the CXCR3 receptor. These proteins together modulate leukocyte movement and activities leading to immunity against pathogens as well as regulation of inflammatory processes.

Associated diseases and disorders

IP-10 has connections with multiple sclerosis and hepatitis C. In multiple sclerosis elevated IP-10 levels correlate with disease severity and progression involving interactions with other chemokines like MCP-1. For hepatitis C IP-10 helps in mediating liver inflammation and fibrosis linking its activity closely with interleukins such as IL-10. Its elevation in these diseases makes IP-10 a potential biomarker for monitoring disease progression and response to therapy.