IP and ChIP antibodies

Our immunoprecipitation (IP) and chromatin immunoprecipitation (ChIP) antibodies have been used in over 10,000 scientific publications. We continually validate and perform QC testing on our antibodies in ChIP and IP to ensure optimal performance.

IP antibodies

IP antibodies are used to isolate their target proteins from a cell or tissue sample, often in conjunction with other proteins and molecules bound to the target protein. Typically, the isolated fraction is then analyzed using gel electrophoresis, western blotting, and other techniques to quantify the amount of target protein and other proteins in that complex.

ChIP antibodies

ChIP is a form of IP, where the antibody is specific for a protein found in or associated with chromatin. For instance, using an antibody against a histone or a transcription factor. Typically, the DNA sequence pulled down in the IP is analyzed using either quantitative PCR (qPCR) or sequencing to help understand which proteins and post-translational modifications of histones and other proteins are associated with specific genes.

Developing ChIP antibodies, particularly for histone modifications, is a cornerstone of our foundation. Abcam began in the lab of Professor Sir Tony Kouzarides, where postdoctoral researcher Jonathan Milner was working on histone biology. That early research helped shape our commitment to supporting scientists with reliable, high-quality antibodies.

Our ChIP-grade antibodies are carefully validated and QC tested for use in ChIP.