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AB9807

Anti-IP10 antibody

4

(9 Reviews)

|

(42 Publications)

Rabbit Polyclonal IP10 antibody. Suitable for WB, sELISA and reacts with Recombinant full length protein - Rat, Recombinant full length protein - Human samples. Cited in 42 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CXCL10.

View Alternative Names

INP10, SCYB10, CXCL10, C-X-C motif chemokine 10, 10 kDa interferon gamma-induced protein, Small-inducible cytokine B10, Gamma-IP10, IP-10

2 Images
Sandwich ELISA - Anti-IP10 antibody (AB9807)
  • sELISA

Supplier Data

Sandwich ELISA - Anti-IP10 antibody (AB9807)

ab9807 detecting IP-10 by sandwich ELISA.

Western blot - Anti-IP10 antibody (AB9807)
  • WB

Unknown

Western blot - Anti-IP10 antibody (AB9807)

All lanes:

Western blot - Anti-IP10 antibody (ab9807) at 1 µg/mL

All lanes:

Western blot - Recombinant rat IP10 protein (<a href='/en-us/products/proteins-peptides/recombinant-rat-ip10-protein-ab75477'>ab75477</a>) at 0.1 µg

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (<a href='/en-us/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-preadsorbed-ab97080'>ab97080</a>) at 1/5000 dilution

Predicted band size: 10 kDa

true

Exposure time: 30s

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Light chain type

unknown

Carrier free

No

Reacts with

Human, Rat

Applications

WB, sELISA

applications

Immunogen

Recombinant Full Length Protein corresponding to Human CXCL10.

P02778

Reactivity data

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Product details

Although some customers have been successful in IHC we no longer batch test in this application.

Properties and storage information

Form
Lyophilized
Reconstitution
Reconstitute with 200µl of sterile water.
Purification technique
Affinity purification Immunogen
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

IP10 also known as CXCL10 is a small cytokine belonging to the CXC chemokine family. It has a molecular mass of approximately 8.7 kDa. IP10 is secreted by several cell types such as monocytes endothelial cells and fibroblasts in response to interferon-gamma (IFN-γ). This protein is involved in immune responses and exhibits various roles especially in chemoattracting cells. Researchers often measure IP10 concentrations using ELISA kits such as the IP-10 ELISA to study its expression levels in different biological contexts.
Biological function summary

IP10 plays a role in modulating the activities of immune cells. It attracts T cells eosinophils monocytes and natural killer (NK) cells by binding to the CXCR3 receptor. IP10 is not part of a larger complex but interacts with other cytokines to influence cell migration and the immune response. High levels of IP10 can reflect strong immune activation which is why it is often measured in inflammatory conditions using standard assays like the IP-10 ELISA kits.

Pathways

The role of IP10 lies within the Th1-type immune response pathway. In this pathway IP10 works alongside other chemokines to recruit and activate immune cells to sites of inflammation or infection. It synergizes with IFN-γ to propagate immune signals. IP10 is also linked with the CXCR3 receptor which plays a critical role in these pathways providing a connection to other proteins such as CXCL9 and CXCL11 which have similar functions in cell-mediated immunity.

IP10 is associated with conditions like multiple sclerosis and rheumatoid arthritis. Elevated IP10 levels often correlate with disease activity in these disorders making it a potential biomarker for disease progression. The protein interacts with other inflammatory mediators such as TNF-α in regulating immune activity within these disease contexts. IP10's involvement in recruiting immune cells contributes to the pathogenic inflammation observed in these conditions.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Target data

Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (PubMed : 11157474, PubMed : 22652417, PubMed : 7540647). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization (PubMed : 12750173, PubMed : 19151743). In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation (PubMed : 12663757, PubMed : 12750173). Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (By similarity).
See full target information CXCL10

Publications (42)

Recent publications for all applications. Explore the full list and refine your search

Arthritis research & therapy 27:173 PubMed40890810

2025

Transforming growth factor beta (TGF-β) induces type 1 interferon signalling in systemic sclerosis keratinocytes through the chloride intracellular channel 4 (CLIC4).

Applications

Unspecified application

Species

Unspecified reactive species

Christopher W Wasson,Sophie L Dibb,Begoña Caballero-Ruiz,Ifeoluwa E Bamigbola,Stefano Di Donato,Eva M Madourie-Clavane,Rebecca Wells,Vishal Kakkar,Enrico De Lorenzis,Jessica Bryon,Emma Derrett-Smith,Christopher P Denton,Yasser El-Sherbiny,Paul J Meakin,Rebecca L Ross,Francesco Del Galdo

International journal of molecular medicine 56: PubMed40682832

2025

Kirenol relieves rheumatoid arthritis by targeting the TWEAK/Fn14 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Zixin Chen,Jinxuan Wang,Lijuan Xiao,Zhihui Chen,Wenchuan Luo,Wen Xu,Ya Lin,Mei Huang,Yuqian Zhang,Yinghao Wang,Yaping Chen,Lihong Nan

Frontiers in cellular and infection microbiology 14:1391824 PubMed39045132

2024

Pathoimmunological analyses of fatal E11 infection in premature infants.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Luo,Lixia Wang,Zhengrong Chen,Ming Liu,Yixue Zhao,Yucan Wu,Bing Huang,Ping Wang

American journal of translational research 15:2676-2689 PubMed37193135

2023

CXCL5 knockdown attenuated gemcitabine resistance of pancreatic cancer through regulation of cancer cells and tumour stroma.

Applications

Unspecified application

Species

Unspecified reactive species

Nien-Hung Lee,Yi Ma,Ching-Seng Ang,Chelsea Dumesny,Nhi Huynh,Yang Yang,Kai Wang,Mehrdad Nikfarjam,Hong He

Thoracic cancer 14:881-892 PubMed36811283

2023

Circ_0001667 accelerates breast cancer proliferation and angiogenesis through regulating CXCL10 expression by sponging miR-6838-5p.

Applications

Unspecified application

Species

Unspecified reactive species

Xu Zhang,Jiami Huang,Jiayun Wang,Yongheng Li,Guohua Hu,He Li

Frontiers in pharmacology 13:905966 PubMed35795557

2022

Curcumenol Mitigates the Inflammation and Ameliorates the Catabolism Status of the Intervertebral Discs Inhibiting the TNFα/NFκB Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao Yang,Baixing Li,Haijun Tian,Xiaofei Cheng,Tangjun Zhou,Jie Zhao

Nature protocols 17:190-221 PubMed35022619

2022

Routine culture and study of adult human brain cells from neurosurgical specimens.

Applications

Unspecified application

Species

Unspecified reactive species

Thomas I-H Park,Leon C D Smyth,Miranda Aalderink,Zoe R Woolf,Justin Rustenhoven,Kevin Lee,Deidre Jansson,Amy Smith,Sheryl Feng,Jason Correia,Peter Heppner,Patrick Schweder,Edward Mee,Mike Dragunow

Journal of the European Academy of Dermatology and Venereology : JEADV 36:144-153 PubMed34585800

2021

Epigallocatechin-3-gallate exhibits anti-inflammatory effects in a human interface dermatitis model-implications for therapy.

Applications

Unspecified application

Species

Unspecified reactive species

C Braegelmann,D Niebel,S Ferring-Schmitt,T Fetter,J Landsberg,M Hölzel,M Effern,N Glodde,S Steinbuch,T Bieber,J Wenzel

Scientific reports 11:18007 PubMed34504204

2021

Role of CXCL10 in the progression of in situ to invasive carcinoma of the breast.

Applications

Unspecified application

Species

Unspecified reactive species

Milim Kim,Hye Yeon Choi,Ji Won Woo,Yul Ri Chung,So Yeon Park

Diagnostics (Basel, Switzerland) 11: PubMed34200333

2021

Active Ratio Test (ART) as a Novel Diagnostic for Ovarian Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Sung-Woog Kang,Adam Rainczuk,Martin K Oehler,Thomas W Jobling,Magdalena Plebanski,Andrew N Stephens
View all publications

Product promise

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