JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB9938

Anti-IP10 antibody

3

(3 Reviews)

|

(14 Publications)

Rabbit Polyclonal IP10 antibody. Suitable for WB and reacts with Mouse samples. Cited in 14 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Mouse Cxcl10.

View Alternative Names

Crg2, Ifi10, Inp10, Scyb10, Cxcl10, C-X-C motif chemokine 10, 10 kDa interferon gamma-induced protein, C7, Interferon-gamma induced protein CRG-2, Small-inducible cytokine B10, Gamma-IP10, IP-10

1 Images
Western blot - Anti-IP10 antibody (AB9938)
  • WB

Unknown

Western blot - Anti-IP10 antibody (AB9938)

Western blot performed with ab9938 at 0.2 ug/ml
Lane 1 : MultiMark MultiColor Standard (Invitrogen)
Lane 2 : 250 ng Murine IP-10
Lane 3 : 125 ng Murine IP-10
Lane 4 : 62.5 ng Murine IP-10
Lane 5 : 31.25 ng Murine IP-10
Lane 6 : 15.625 ng Murine IP-10
Lane 7 : 7.8 ng Murine IP-10
Lane 8 : 3.9 ng Murine IP-10
Lane 9 : 1.95 ng Murine IP-10
Lane 10 : 0.975 ng Murine IP-10
Lane 11 : 0.4875 ng Murine IP-10
Lane 12 0.24 ng Murine IP-10

All lanes:

Western blot - Anti-IP10 antibody (ab9938)

Predicted band size: 10 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

Unknown

Light chain type

unknown

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Mouse Cxcl10.

P17515

Specificity

This antibody does not cross-react with murine CXCL9 and CXCL11.

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p>To detect mIP-10 by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 µg/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant mIP-10 is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.</p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Lyophilized
Reconstitution
Reconstitute with 200µl of sterile water.
Purification technique
Affinity purification Immunogen
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

IP10 also known as CXCL10 is a small cytokine belonging to the CXC chemokine family. It has a molecular mass of approximately 8.7 kDa. IP10 is secreted by several cell types such as monocytes endothelial cells and fibroblasts in response to interferon-gamma (IFN-γ). This protein is involved in immune responses and exhibits various roles especially in chemoattracting cells. Researchers often measure IP10 concentrations using ELISA kits such as the IP-10 ELISA to study its expression levels in different biological contexts.
Biological function summary

IP10 plays a role in modulating the activities of immune cells. It attracts T cells eosinophils monocytes and natural killer (NK) cells by binding to the CXCR3 receptor. IP10 is not part of a larger complex but interacts with other cytokines to influence cell migration and the immune response. High levels of IP10 can reflect strong immune activation which is why it is often measured in inflammatory conditions using standard assays like the IP-10 ELISA kits.

Pathways

The role of IP10 lies within the Th1-type immune response pathway. In this pathway IP10 works alongside other chemokines to recruit and activate immune cells to sites of inflammation or infection. It synergizes with IFN-γ to propagate immune signals. IP10 is also linked with the CXCR3 receptor which plays a critical role in these pathways providing a connection to other proteins such as CXCL9 and CXCL11 which have similar functions in cell-mediated immunity.

IP10 is associated with conditions like multiple sclerosis and rheumatoid arthritis. Elevated IP10 levels often correlate with disease activity in these disorders making it a potential biomarker for disease progression. The protein interacts with other inflammatory mediators such as TNF-α in regulating immune activity within these disease contexts. IP10's involvement in recruiting immune cells contributes to the pathogenic inflammation observed in these conditions.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity) (PubMed : 28623423). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (PubMed : 18624292, PubMed : 19017990, PubMed : 28468883). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation (By similarity). Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (PubMed : 15456824).
See full target information Cxcl10
style
left-column

Publications (14)

Recent publications for all applications. Explore the full list and refine your search

Small science 5:2500208 PubMed40837039

2025

Cerium Oxide Nanoparticles Achieve Long-Lasting Senescence Inhibition in an Aging Mouse Model of Sarcopenia via Reactive Oxygen Species Scavenging and CILP2 Downregulation.

Applications

Unspecified application

Species

Unspecified reactive species

Wei-Chih Lien,Yu-Ling Yu,Ya-Jyun Liang,Chia-Yih Wang,Yang-Chen Lin,Huei-Cih Chang,Feng-Huei Lin,Hui-Min David Wang

PLoS pathogens 21:e1013051 PubMed40245000

2025

RNF149 modulates the type I IFN innate antiviral immune responses through degrading IRF3.

Applications

Unspecified application

Species

Unspecified reactive species

Mengyun Wu,Jiamin Cai,Guodong Qiao,Xiaoping Li,Ji Zhou,Fei Xu,Yunfei Ye,Yufeng Wang,Xuena Xu,Jiaoyang Li,Xiaoyu Tian,Yu Shao,Chunsheng Dong,Zhengrong Chen,Chuangli Hao,Yi Yang,Jinping Zhang

ASN neuro 17:2472070 PubMed40063988

2025

A Brain Endothelial Cell Caveolin-1/CXCL10 Axis Promotes T Cell Transcellular Migration Across the Blood-Brain Barrier.

Applications

Unspecified application

Species

Unspecified reactive species

Troy N Trevino,Ali A Almousawi,Remy Martins-Goncalves,Andrea Ochoa-Raya,KaReisha F Robinson,Genesis L Abad,Leon M Tai,Suellen D Oliveira,Richard D Minshall,Sarah E Lutz

International journal of molecular sciences 24: PubMed37445879

2023

Skin Wound following Irradiation Aggravates Radiation-Induced Brain Injury in a Mouse Model.

Applications

Unspecified application

Species

Unspecified reactive species

Mang Xiao,Xianghong Li,Li Wang,Bin Lin,Min Zhai,Lisa Hull,Alex Zizzo,Wanchang Cui,Juliann G Kiang

Bioengineering & translational medicine 8:e10346 PubMed36684074

2023

Therapeutic potential of nanoceria pretreatment in preventing the development of urological chronic pelvic pain syndrome: Immunomodulation via reactive oxygen species scavenging and SerpinB2 downregulation.

Applications

Unspecified application

Species

Unspecified reactive species

Wei-Chih Lien,Xin-Ran Zhou,Ya-Jyun Liang,Congo Tak-Shing Ching,Chia-Yih Wang,Fu-I Lu,Huei-Cih Chang,Feng-Huei Lin,Hui-Min David Wang

Marine drugs 19: PubMed33805447

2021

Combination of Fish Oil and Selenium Enhances Anticancer Efficacy and Targets Multiple Signaling Pathways in Anti-VEGF Agent Treated-TNBC Tumor-Bearing Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Chih-Hung Guo,Simon Hsia,Chieh-Han Chung,Yi-Chun Lin,Min-Yi Shih,Pei-Chung Chen,Guoo-Shyng W Hsu,Ciou-Ting Fan,Chia-Lin Peng

Nature neuroscience 24:234-244 PubMed33526922

2021

CNS fibroblasts form a fibrotic scar in response to immune cell infiltration.

Applications

Unspecified application

Species

Unspecified reactive species

Cayce E Dorrier,Dvir Aran,Ezekiel A Haenelt,Ryan N Sheehy,Kimberly K Hoi,Lucija Pintarić,Yanan Chen,Carlos O Lizama,Kelly M Cautivo,Geoffrey A Weiner,Brian Popko,Stephen P J Fancy,Thomas D Arnold,Richard Daneman

PLoS neglected tropical diseases 14:e0008223 PubMed32324736

2020

Study of Usutu virus neuropathogenicity in mice and human cellular models.

Applications

Unspecified application

Species

Unspecified reactive species

Marion Clé,Jonathan Barthelemy,Caroline Desmetz,Vincent Foulongne,Lina Lapeyre,Karine Bolloré,Edouard Tuaillon,Nejla Erkilic,Vasiliki Kalatzis,Sylvie Lecollinet,Cécile Beck,Nelly Pirot,Yaël Glasson,Fabien Gosselet,Maria Teresa Alvarez Martinez,Philippe Van de Perre,Sara Salinas,Yannick Simonin

Virologica Sinica 35:614-625 PubMed32314275

2020

IP10, KC and M-CSF Are Remarkably Increased in the Brains from the Various Strains of Experimental Mice Infected with Different Scrapie Agents.

Applications

Unspecified application

Species

Unspecified reactive species

Jia Chen,Cao Chen,Chao Hu,Lian Liu,Ying Xia,Lin Wang,Wei Yang,Hai-Yan Wu,Wei Zhou,Kang Xiao,Qi Shi,Yuezhang Wu,Zhi-Bao Chen,Xiao-Ping Dong

JCI insight 4: PubMed30728335

2019

Cxcr3-expressing leukocytes are necessary for neurofibroma formation in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Jonathan S Fletcher,Jianqiang Wu,Walter J Jessen,Jay Pundavela,Jacob A Miller,Eva Dombi,Mi-Ok Kim,Tilat A Rizvi,Kashish Chetal,Nathan Salomonis,Nancy Ratner
View all publications
style
left-column
style
left-column
style
right-column

Alternative Products

Primary Antibodies

AB9807

Anti-IP10 antibody

Sandwich ELISA - Anti-IP10 antibody (AB9807)

  • 4
  • 9
Primary Antibodies

AB214668

Anti-IP10 antibody [EPR20764]

RabMAb|Recombinant|KO Validated

Western blot - Anti-IP10 antibody [EPR20764] (AB214668)

  • 0
  • 0
Primary Antibodies

AB137018

Anti-IP10 antibody [EPR7850]

RabMAb|Recombinant|KO Validated

Indirect ELISA - Anti-IP10 antibody [EPR7850] (AB137018)

  • 0
  • 0
Primary Antibodies

AB224678

Anti-IP10 antibody [EPR20764] - BSA and Azide free

RabMAb|Recombinant|KO Validated

Western blot - Anti-IP10 antibody [EPR20764] - BSA and Azide free (AB224678)

  • 0
  • 0

Complementary Products

Assay Kits

AB173194

Human IP-10 ELISA Kit

SimpleStep

ELISA - Human IP-10 ELISA Kit (AB173194)

  • 5
  • 1
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB288437

Anti-CXCR3 antibody [EPR25373-32]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CXCR3 antibody [EPR25373-32] (AB288437)

  • 4
  • 1
Primary Antibodies

AB45690

Anti-CCL4/MIP-1 beta antibody [EP521Y]

RabMAb|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-CCL4/MIP-1 beta antibody [EP521Y] (AB45690)

  • 1
  • 1
Primary Antibodies

AB68428

Anti-GFAP antibody [EPR1034Y] - Astrocyte Marker

BOND RX™ Validated|20ul selling size|RabMAb|Advanced Validation|Recombinant

Multiplex immunohistochemistry - Anti-GFAP antibody [EPR1034Y] - Astrocyte Marker (AB68428)

  • 5
  • 19

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com