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AB179921

Anti-IP6K2 antibody

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(3 Publications)

Rabbit Polyclonal IP6K2 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, African green monkey samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human IP6K2.

View Alternative Names

IHPK2, TCCCIA00113, IP6K2, Inositol hexakisphosphate kinase 2, InsP6 kinase 2, InsP6K2, P(i)-uptake stimulator, PiUS

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IP6K2 antibody (AB179921)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IP6K2 antibody (AB179921)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human small intestine tissue labeling IP6K2 with ab179921 at 20 μg/ml.

Immunocytochemistry/ Immunofluorescence - Anti-IP6K2 antibody (AB179921)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-IP6K2 antibody (AB179921)

Immunofluorescent analysis of COS-7 (African green monkey kidney fibroblast-like cell line) cells labeling IP6K2 with ab179921 at 1/100 dilution. The image on the right is treated with the synthesized peptide.

Western blot - Anti-IP6K2 antibody (AB179921)
  • WB

Supplier Data

Western blot - Anti-IP6K2 antibody (AB179921)

All lanes:

Anti-RFPL1 antibody (<a href='/en-us/products/unavailable/rfpl1-antibody-ab172291'>ab172291</a>) at 1/500 dilution

Lane 1:

HUVEC cell lysate

Lane 2:

Jurkat cell lysate

Lane 3:

COLO cell lysate

Lane 4:

COLO cell lysate with Immunizing peptide

Predicted band size: 49 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human, African green monkey

Applications

IHC-P, WB, ICC/IF

applications

Immunogen

Synthetic Peptide within Human IP6K2. The exact immunogen used to generate this antibody is proprietary information.

Q9UHH9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "20 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "African green monkey": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/500", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The IP6K2 protein also known as inositol hexakisphosphate kinase 2 functions mechanically as an enzyme that converts inositol hexakisphosphate (IP6) into diphosphoinositol pentakisphosphate (IP7). It has a molecular mass of about 55 kDa. This kinase is widely expressed in various tissues with significant levels found in the brain and testes. IP6K2 activity plays a role in cellular energy homeostasis and signaling.
Biological function summary

IP6K2 influences several cellular processes including apoptosis and cell cycle regulation. It operates as a part of protein complexes that mediate the synthesis of inositol pyrophosphates which are important secondary messengers in cells. Through these roles IP6K2 helps regulate physiological functions such as insulin signaling and energy balance. Its interactions with various binding partners also enable it to influence cell survival and growth parameters.

Pathways

IP6K2 is actively involved in the inositol phosphate metabolism and apoptosis pathways. Inositol phosphate metabolism involves a range of signaling molecules where IP6K2 contributes to the generation of key signaling lipids. It works in conjunction with other kinases such as IP6K1 and phosphatidylinositol 3-kinase (PI3K) facilitating complex cellular activities. Through these pathways IP6K2 modulates processes that are essential for maintaining cell viability and proper cellular responses to external stimuli.

Dysregulation of IP6K2 has associations with several conditions including cancer and metabolic disorders. Altered IP6K2 function can influence cancer development by affecting apoptotic pathways where it interacts with key proteins such as p53 to regulate cell death. In metabolic disorders the kinase's role in insulin signaling connects it to metabolic issues like type 2 diabetes as its involvement in signal transduction impacts glucose homeostasis and insulin sensitivity.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5).
See full target information IP6K2
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

The Journal of biological chemistry 299:102928 PubMed36681123

2023

Inositol pyrophosphate profiling reveals regulatory roles of IP6K2-dependent enhanced IP metabolism in the enteric nervous system.

Applications

Unspecified application

Species

Unspecified reactive species

Masatoshi Ito,Natsuko Fujii,Saori Kohara,Shuho Hori,Masayuki Tanaka,Christopher Wittwer,Kenta Kikuchi,Takatoshi Iijima,Yu Kakimoto,Kenichi Hirabayashi,Daisuke Kurotaki,Henning J Jessen,Adolfo Saiardi,Eiichiro Nagata

Biosensors 12: PubMed35323432

2022

Magnetic Immunosensor Coupled to Enzymatic Signal for Determination of Genomic DNA Methylation.

Applications

Unspecified application

Species

Unspecified reactive species

Yitao Liang,Bin Zhang,Zexin Xue,Xuesong Ye,Bo Liang

Bioengineered 13:3370-3382 PubMed35156508

2022

LINC00467 facilitates the proliferation, migration and invasion of glioma via promoting the expression of inositol hexakisphosphate kinase 2 by binding to miR-339-3p.

Applications

Unspecified application

Species

Unspecified reactive species

Yin Zhang,Yaxuan Zhang,Sen Wang,Boqiang Cao,Daling Hu,Junli Jia,Yuhang Wang,Luyao Chen,Jiaming Li,Hongyi Liu,Huamin Tang
View all publications
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Product promise

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