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AB46783

Anti-IPL-1/STK13/Aurora C antibody [EP1011Y]

1

(1 Review)

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(2 Publications)

Rabbit Recombinant Monoclonal IPL-1/STK13/Aurora C antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications.

View Alternative Names

AIE2, AIK3, AIRK3, ARK3, STK13, AURKC, Aurora kinase C, Aurora 3, Aurora/IPL1-related kinase 3, Aurora/IPL1/Eg2 protein 2, Serine/threonine-protein kinase 13, Serine/threonine-protein kinase aurora-C, ARK-3, Aurora-related kinase 3

1 Images
Western blot - Anti-IPL-1/STK13/Aurora C antibody [EP1011Y] (AB46783)
  • WB

Unknown

Western blot - Anti-IPL-1/STK13/Aurora C antibody [EP1011Y] (AB46783)

All lanes:

Western blot - Anti-IPL-1/STK13/Aurora C antibody [EP1011Y] (ab46783) at 1/1000 dilution

All lanes:

HepG2 lysate at 10 µg

Secondary

All lanes:

goat anti rabbit HRP at 1/2000 dilution

Predicted band size: 36 kDa

Observed band size: 36 kDa

false

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EP1011Y

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

This antibody is not recommended in tissue lysate testing.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Stable for 12 months at -20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

IPL-1 also known as STK13 or Aurora C is a serine/threonine protein kinase with a molecular mass of approximately 39 kDa. It expresses mainly in testis and ovarian tissue playing a significant role in cell division. As a member of the Aurora kinase family IPL-1 functions mechanistically in regulating the centrosome during cell cycle progression ensuring the proper segregation of chromosomes during mitosis and meiosis. The protein undergoes phosphorylation to activate its kinase activity which is essential for its role in chromatin modification and assembly of microtubules.
Biological function summary

IPL-1 functions in chromosomal alignment and cytokinesis during cell division. It forms part of the chromosomal passenger complex (CPC) along with INCENP Survivin and Borealin. This complex is essential for correcting errors in chromosome segregation. IPL-1's activity helps maintain genomic stability by ensuring that cells divide correctly. Given its role in the chromosomal passenger complex IPL-1 is critical in monitoring and controlling the accurate distribution of genetic material between daughter cells.

Pathways

IPL-1 is intricately involved in cellular processes like the mitotic spindle checkpoint and the regulation of the mitotic cell cycle. It interacts with other proteins such as Aurora B which shares similar functions in the mitotic pathway. IPL-1 helps coordinate the activities of these pathways and proteins to ensure orderly cell division. Through these pathways IPL-1 influences the balance of cell proliferation and cell death which is important for normal organismal development and function.

Misregulation of IPL-1 is associated with cancers including ovarian and testicular cancer. Aberrant expression or activation of IPL-1 can lead to chromosomal instability contributing to tumorigenesis. Additionally the overexpression of Aurora kinase family members including IPL-1 often co-occurs with Cyclin B1 dysregulation in cancer cells. The connection between IPL-1 and Cyclin B1 highlights potential therapeutic targets for cancer treatment as researchers continue to explore strategies for inhibiting IPL-1 to restore normal cell cycle control in tumor cells.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Also plays a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.
See full target information AURKC
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Molecular therapy. Nucleic acids 23:731-742 PubMed33575118

2021

Targeting the 5' untranslated region of as a therapeutic strategy for spinal muscular atrophy.

Applications

Unspecified application

Species

Unspecified reactive species

Audrey M Winkelsas,Christopher Grunseich,George G Harmison,Katarzyna Chwalenia,Carlo Rinaldi,Suzan M Hammond,Kory Johnson,Melissa Bowerman,Sukrat Arya,Kevin Talbot,Matthew J Wood,Kenneth H Fischbeck

Cell death & disease 11:1021 PubMed33257688

2020

BRDT promotes ovarian cancer cell growth.

Applications

Unspecified application

Species

Unspecified reactive species

Ling Chen,Shang Cai,Jing-Mei Wang,Ying-Ying Huai,Pei-Hua Lu,Qian Chu
View all publications
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Product promise

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