AB169241

Anti-IPMK antibody

Name: Anti-IPMK antibody (ab169241) | Abcam
Brand: Abcam Limited
SKU: AB169241
Price: 535 USD
Availability: InStock

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(2 Publications)

Mouse Polyclonal IPMK antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human IPMK.

View Alternative Names

IMPK, IPMK, Inositol polyphosphate multikinase

2 Images

Immunocytochemistry/ Immunofluorescence - Anti-IPMK antibody (AB169241)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-IPMK antibody (AB169241)

Immunocytochemistry/ Immunofluorescence analysis of HeLa cells labeling IPMK with ab169241 at 10μg/ml.

Unknown

Western blot - Anti-IPMK antibody (AB169241)

All lanes:

Western blot - Anti-IPMK antibody (ab169241) at 1 µg/mL

Lane 1:

IPMK transfected 293T lysate at 15 µL

Lane 2:

Non-transfected 293T lysate at 15 µL

Secondary

All lanes:

Goat Anti-Mouse IgG at 1/2500 dilution

Predicted band size: 47 kDa

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Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Full Length Protein corresponding to Human IPMK.

Q8NFU5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Chimpanzee": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Common marmoset": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rabbit": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rhesus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The inositol polyphosphate multikinase (IPMK) also known as Ipk2 or Arg82 functions as an important enzyme that catalyzes the phosphorylation of inositol phosphates. IPMK performs its functions by converting inositol 145-trisphosphate to inositol 1345-tetrakisphosphate. The protein weighs approximately 45 kDa and is expressed in various tissues including the brain liver and kidney. In these tissues IPMK interacts with cellular components to regulate its activity further.

Biological function summary

The enzyme IPMK plays a significant role in cellular signaling processes and acts as a part of the inositol phosphate metabolic pathway. It participates in the regulation of gene expression by associating with transcription factors and chromatin remodeling complexes. Researchers have identified it as contributing to both nuclear and cytoplasmic signaling and its impact on processes like cell proliferation and apoptosis is well documented.

Pathways

IPMK engages in critical intracellular signaling networks such as the PI3K/AKT pathway which influence cell growth and survival. It links with other proteins like PI3K enhancing the pathway's browser of growth factors. In the inositol signaling pathway IPMK interacts with kinases and phosphatases illustrating its function in modulating cellular responses to external stimuli. These pathways help with the organism's development and maintenance by guiding important cellular functions.

IPMK has been associated with conditions like cancer and neurodegenerative disorders. In cancer its regulation of the PI3K/AKT pathway associates it with oncogenic processes where abnormal cell growth occurs. In neurodegenerative disorders studies suggest IPMK interaction with proteins involved in neuroprotection like AKT may influence disease progression. This relationship opens avenues for therapeutic strategies targeting IPMK and its related pathways to mitigate the adverse effects of these diseases.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

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Target data

Inositol phosphate kinase with a broad substrate specificity (PubMed : 12027805, PubMed : 12223481, PubMed : 28882892, PubMed : 30420721, PubMed : 30624931). Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) (PubMed : 12027805, PubMed : 12223481, PubMed : 28882892, PubMed : 30624931). Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) (PubMed : 12223481). Phosphorylates inositol 1,4,5,6-tetrakisphosphate (Ins(1,4,5,6)P4) (By similarity). Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3,4,5-trisphosphate (PubMed : 28882892, PubMed : 30420721). Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Binding of these highly phosphorylated inositol phosphates to MLKL mediates the release of an N-terminal auto-inhibitory region, leading to activation of the kinase. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed : 29883610). Required for normal embryonic development, probably via its role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) and inositol hexakisphosphate (InsP6) (By similarity).

See full target information IPMK

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

General physiology and biophysics 44:337-348 PubMed40567076

2025

Exosomal microRNA-22-3p influences oxidative stress injury and neuronal apoptosis in Alzheimer's disease via targeting KDM6B.

Applications

Unspecified application

Species

Unspecified reactive species

Luzy Zhang

International journal of biological sciences 19:537-551 PubMed36632464

2023

Ebastine exerts antitumor activity and induces autophagy by activating AMPK/ULK1 signaling in an IPMK-dependent manner in osteosarcoma.

Applications

Unspecified application

Species

Unspecified reactive species

Zhen Pan,Shi-Jie Li,Hua Guo,Zhao-Hui Li,Xiang Fei,Shi-Min Chang,Qing-Cheng Yang,Dong-Dong Cheng

View all publications

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Product promise

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-IPMK antibody

Immunocytochemistry/ Immunofluorescence - Anti-IPMK antibody (AB169241)

Western blot - Anti-IPMK antibody (AB169241)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

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