Anti-IREB2/IRP2 antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

IREB2 regulates the stability and translation of mRNAs encoding proteins linked to iron uptake storage and utilization. It plays an important role outside of a complex acting primarily on its own to bind transcripts that include ferritin and transferrin receptor mRNAs. Its activity increases under conditions of low iron availability promoting iron uptake and reducing iron sequestration to meet metabolic needs. Through these mechanisms IREB2 helps maintain iron supply for essential enzymes and cellular processes.

Pathways

IREB2 acts as a central player in the iron metabolism pathway influencing both iron import and storage. The pathways it participates in are essential for maintaining cellular and systemic iron balance. It works in coordination with IRP1 forming a regulatory network that adjusts iron homeostasis. Under varying iron concentrations IREB2 modulates expression of its target genes involved in iron transport and storage within the framework of the iron-sulfur cluster biosynthesis pathway.