AB236392

Anti-IRF2BP1 antibody [OTI3A6]

Name: Anti-IRF2BP1 antibody [OTI3A6] (ab236392) | Abcam
Brand: Abcam Limited
SKU: AB236392
Price: 525 USD
Availability: InStock

Be the first to review this product! Submit a review

(1 Publication)

Mouse Monoclonal IRF2BP1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human IRF2BP1 aa 450 to C-terminus.

View Alternative Names

Interferon regulatory factor 2-binding protein 1, IRF-2-binding protein 1, IRF-2BP1, Probable E3 ubiquitin-protein ligase IRF2BP1, Probable RING-type E3 ubiquitin transferase IRF2BP1, IRF2BP1

7 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IRF2BP1 antibody [OTI3A6] (AB236392)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IRF2BP1 antibody [OTI3A6] (AB236392)

Paraffin-embedded human prostate carcinoma tissue stained for IRF2BP1 using ab236392 at 1/500 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IRF2BP1 antibody [OTI3A6] (AB236392)

Paraffin-embedded human thyroid tissue stained for IRF2BP1 using ab236392 at 1/500 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IRF2BP1 antibody [OTI3A6] (AB236392)

Paraffin-embedded human liver tissue stained for IRF2BP1 using ab236392 at 1/500 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IRF2BP1 antibody [OTI3A6] (AB236392)

Paraffin-embedded human breast tissue stained for IRF2BP1 using ab236392 at 1/500 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IRF2BP1 antibody [OTI3A6] (AB236392)

Paraffin-embedded human kidney tissue stained for IRF2BP1 using ab236392 at 1/500 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IRF2BP1 antibody [OTI3A6] (AB236392)

Paraffin-embedded human breast adenocarcinoma tissue stained for IRF2BP1 using ab236392 at 1/500 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IRF2BP1 antibody [OTI3A6] (AB236392)

Paraffin-embedded human prostate tissue stained for IRF2BP1 using ab236392 at 1/500 dilution in immunohistochemical analysis.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

OTI3A6

Isotype

IgG2b

Carrier free

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human IRF2BP1 aa 450 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q8IU81

style

left-column

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500", "IHCP-species-notes": "<p>Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 8.5 before commencing with IHC staining protocol.</p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

style

left-column

style

left-column

Properties and storage information

Form

Liquid

Purification technique

Affinity purification

Purification notes

Purified from cell culture supernatant.

Storage buffer

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

style

left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

IRF2BP1 also known as Interferon Regulatory Factor 2 Binding Protein 1 is a protein involved in regulating gene expression. It has a molecular mass of approximately 64 kDa. This protein plays a role as a transcriptional corepressor meaning it helps repress the activity of certain genes. IRF2BP1 is expressed in various tissues with notable expression in immune cells which suggests its involvement in immune system regulation.

Biological function summary

IRF2BP1 interacts with other proteins to modulate transcriptional repression. It forms part of a complex that includes other co-repressors which collaborate to regulate gene expression tightly. One of its main functions is to inhibit the activity of IRF2 an important transcription factor involved in innate immunity. This inhibition allows for fine-tuning of the immune response and helps maintain immune homeostasis.

Pathways

IRF2BP1 functions within the interferon signaling pathway playing a regulatory role by modulating IRF2 activity. This pathway is important for responding to viral infections and other immune challenges. By interacting with IRF2 IRF2BP1 controls gene expression related to immune response. Additionally IRF2BP1 is involved in pathways related to transcriptional regulation where it may impact the expression of genes under specific conditions.

IRF2BP1 has associations with autoimmune diseases and cancer. Its role in repressing IRF2 suggests that dysregulation could lead to imbalances in the immune response potentially contributing to conditions like systemic lupus erythematosus. Furthermore its activity links to cancer where aberrant expression or function might result in disrupted cell growth and apoptosis. In these contexts IRF1 another immune regulatory protein may interact with IRF2BP1 impacting the outcomes related to such diseases.

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation.

See full target information IRF2BP1

style

left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of experimental & clinical cancer research : CR 41:13 PubMed34996491

2022

INPP5F translocates into cytoplasm and interacts with ASPH to promote tumor growth in hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Qianlei Zhou,Jianhong Lin,Yongcong Yan,Shiyu Meng,Hao Liao,Ruibin Chen,Gui He,Yue Zhu,Chuanchao He,Kai Mao,Jie Wang,Jianlong Zhang,Zhenyu Zhou,Zhiyu Xiao

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-IRF2BP1 antibody [OTI3A6]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IRF2BP1 antibody [OTI3A6] (AB236392)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IRF2BP1 antibody [OTI3A6] (AB236392)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IRF2BP1 antibody [OTI3A6] (AB236392)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IRF2BP1 antibody [OTI3A6] (AB236392)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IRF2BP1 antibody [OTI3A6] (AB236392)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IRF2BP1 antibody [OTI3A6] (AB236392)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IRF2BP1 antibody [OTI3A6] (AB236392)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Product promise