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AB114997

Anti-IRF2BP2 antibody

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Rabbit Polyclonal IRF2BP2 antibody. Suitable for IP and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human IRF2BP2 aa 200-300.

View Alternative Names

Interferon regulatory factor 2-binding protein 2, IRF-2-binding protein 2, IRF-2BP2, IRF2BP2

1 Images
Immunoprecipitation - Anti-IRF2BP2 antibody (AB114997)
  • IP

Unknown

Immunoprecipitation - Anti-IRF2BP2 antibody (AB114997)

Immunoprecipitation : 1 mg of HeLa cell lysate immunoprecipitated using ab114997 at 6 µg/mg lysate; 20% of immunoprecipitate was loaded/lane.
Western Blot of immunoprecipitate : Anti-IRF2BP2 antibody at 1 µg/ml.
Developed using the ECL technique
Exposure time : 1 second
Predicted band size : 61 kDa

All lanes:

Immunoprecipitation - Anti-IRF2BP2 antibody (ab114997)

Predicted band size: 54 kDa,61 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IP

applications

Immunogen

Synthetic Peptide within Human IRF2BP2 aa 200-300. The exact immunogen used to generate this antibody is proprietary information.

Q7Z5L9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-10 µg/mg of lysate", "IP-species-notes": "<p></p>" }, "Chimpanzee": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Rhesus monkey": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab114997 was affinity purified using an epitope specific to IRF2BP2 immobilized on solid support.
Storage buffer
pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: 99% Tris citrate/phosphate
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The IRF2BP2 also known as Interferon Regulatory Factor 2 Binding Protein 2 has a mass of approximately 68 kDa. This protein acts mechanically as a transcriptional coregulator. It is involved in the regulation of gene expression by modulating the activity of the transcription factor IRF2. IRF2BP2 is found to be expressed in multiple tissues including the heart spleen and thymus which indicates its broad physiological significance.
Biological function summary

Acting as a transcriptional coregulator IRF2BP2 influences immune response cell differentiation and apoptosis. It functions in conjunction with other cellular components and may form complexes with proteins such as IRF2 and other transcription factors. The protein plays an important role in controlling immune function by either enhancing or suppressing gene expression in response to cellular stimuli.

Pathways

IRF2BP2 involves itself in the immune signaling pathways such as the NF-kB signaling. It also connects to the MAPK signaling pathway which is critical for cellular responses to stress and cytokines. It works closely with proteins such as NF-kB and IRF2 which are significant to these pathways and influence the transcription of target genes.

IRF2BP2 associates with cardiovascular disease and certain inflammatory conditions. In cardiovascular disease this protein may affect heart-related genes mainly through its interaction with IRF2 and possibly through the modulation of inflammatory responses. In inflammatory disorders IRF2BP2 has a regulatory function which involves NF-kB to control excessive inflammatory gene expression influencing disease progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed : 12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed : 21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed : 20702774). Plays a role in immature B-cell differentiation (PubMed : 27016798).
See full target information IRF2BP2
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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