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AB124163

Anti-IRF2BP2 antibody

3

(4 Reviews)

|

(1 Publication)

Rabbit Polyclonal IRF2BP2 antibody. Suitable for WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human IRF2BP2.

View Alternative Names

Interferon regulatory factor 2-binding protein 2, IRF-2-binding protein 2, IRF-2BP2, IRF2BP2

1 Images
Western blot - Anti-IRF2BP2 antibody (AB124163)
  • WB

Unknown

Western blot - Anti-IRF2BP2 antibody (AB124163)

All lanes:

Western blot - Anti-IRF2BP2 antibody (ab124163) at 1/1 dilution

Lane 1:

HeLa cell lysate at 15 µg

Lane 2:

HeLa cell lysate at 15 µg with blocking peptide

Predicted band size: 61 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human, Mouse

Applications

WB

applications

Immunogen

Synthetic Peptide within Human IRF2BP2. The exact immunogen used to generate this antibody is proprietary information.

Q7Z5L9

Specificity

At least two isoforms of IRF2BP2 are known to exist; this antibody will detect both. This antibody is predicted to not cross-react with any FOXD4 protein family members.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The IRF2BP2 also known as Interferon Regulatory Factor 2 Binding Protein 2 has a mass of approximately 68 kDa. This protein acts mechanically as a transcriptional coregulator. It is involved in the regulation of gene expression by modulating the activity of the transcription factor IRF2. IRF2BP2 is found to be expressed in multiple tissues including the heart spleen and thymus which indicates its broad physiological significance.
Biological function summary

Acting as a transcriptional coregulator IRF2BP2 influences immune response cell differentiation and apoptosis. It functions in conjunction with other cellular components and may form complexes with proteins such as IRF2 and other transcription factors. The protein plays an important role in controlling immune function by either enhancing or suppressing gene expression in response to cellular stimuli.

Pathways

IRF2BP2 involves itself in the immune signaling pathways such as the NF-kB signaling. It also connects to the MAPK signaling pathway which is critical for cellular responses to stress and cytokines. It works closely with proteins such as NF-kB and IRF2 which are significant to these pathways and influence the transcription of target genes.

IRF2BP2 associates with cardiovascular disease and certain inflammatory conditions. In cardiovascular disease this protein may affect heart-related genes mainly through its interaction with IRF2 and possibly through the modulation of inflammatory responses. In inflammatory disorders IRF2BP2 has a regulatory function which involves NF-kB to control excessive inflammatory gene expression influencing disease progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed : 12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed : 21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed : 20702774). Plays a role in immature B-cell differentiation (PubMed : 27016798).
See full target information IRF2BP2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular vision 28:500-506 PubMed37089701

2022

Epac1 and PKA agonists inhibit ROS to reduce NLRP3 inflammasome proteins in retinal endothelial cells.

Applications

Unspecified application

Species

Unspecified reactive species

Li Liu,Youde Jiang,Jena J Steinle
View all publications
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Product promise

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