Anti-ISCA2 antibody

Supplementary info

Activity summary

ISCA2 also known as Iron-Sulfur Cluster Assembly 2 is a protein involved in the assembly of iron-sulfur clusters essential for various cellular processes. This protein has a molecular weight of approximately 14 kDa. ISCA2 is expressed in numerous tissues including the heart liver and skeletal muscles. It plays a fundamental role in the synthesis of these clusters which are integral for electron transfer and enzymatic reactions.

Biological function summary

The protein ISCA2 participates in the maturation of iron-sulfur cluster-containing proteins critical for mitochondrial function. As part of a larger complex ISCA2 collaborates with other proteins like ISCA1 and IBA57 to facilitate the transfer and insertion of these clusters into target proteins. This action supports the stability and functionality of key mitochondrial enzymes assisting in cellular respiration and redox homeostasis.

Pathways

Iron-sulfur cluster biogenesis involves ISCA2 and integrates into critical pathways like the mitochondrial respiratory chain and the citric acid cycle. Within these pathways ISCA2 operates alongside related proteins such as NFS1 and FXN ensuring proper cluster delivery and activity. These pathways are vital for maintaining cellular energy production and metabolic balance emphasizing ISCA2’s significant role.

Associated diseases and disorders

ISCA2 mutations have been implicated in mitochondrial diseases like multiple mitochondrial dysfunctions syndrome (MMDS). This disorder includes neurologic abnormalities due to defective mitochondrial protein function. ISCA2 is connected to MMDS alongside proteins such as ISCA1 and IBA57 which also partake in the cluster assembly machinery highlighting the protein’s broader importance in human health.