Anti-Islet Cell antibody [LIV3D3]

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

The clusters of hormone-producing cells regulate blood glucose levels. The islet cells function as part of the endocrine system of the pancreas with beta cells being the most common and significant component. The interaction between different cell types within the islet facilitates the fine-tuning of insulin and glucagon secretion maintaining glucose homeostasis. Islet cells do not work alone; they interact with nerves and blood vessels forming a critical interface between hormone secretion and systemic circulation.

Pathways

Islet cell function integrates within the insulin signaling pathway and the glucagon signaling pathway. These pathways maintain glucose stability in the bloodstream. Insulin secretion involves cascades like the PI3K/Akt pathway which talks with insulin receptors on target tissues. Relation to glucagon occurs through the cAMP-dependent pathway influencing gluconeogenesis and glycogenolysis. Islet cells communicate with proteins such as GLUT2 and glucokinase important in glucose sensing and metabolism.