AB232986

Anti-ISLR antibody

Name: Anti-ISLR antibody (ab232986) | Abcam
Brand: Abcam Limited
SKU: AB232986
Price: 525 USD
Availability: InStock

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(3 Publications)

Rabbit Polyclonal ISLR antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ISLR.

View Alternative Names

UNQ189/PRO215, ISLR, Immunoglobulin superfamily containing leucine-rich repeat protein

5 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ISLR antibody (AB232986)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ISLR antibody (AB232986)

Formalin-fixed, paraffin-embedded human stomach tissue stained for ISLR with ab232986 at 20 μg/ml in immunohistochemical analysis.

Secondary used : HRP-Linked Goat anti-Rabbit IgG polyclonal at 2 μg/ml. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ISLR antibody (AB232986)

Formalin-fixed, paraffin-embedded human kidney tissue stained for ISLR with ab232986 at 20 μg/ml in immunohistochemical analysis.

Secondary used : HRP-Linked Goat anti-Rabbit IgG polyclonal at 2 μg/ml. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ISLR antibody (AB232986)

Formalin-fixed, paraffin-embedded human prostate tissue stained for ISLR with ab232986 at 20 μg/ml in immunohistochemical analysis.

Secondary used : HRP-Linked Goat anti-Rabbit IgG polyclonal at 2 μg/ml. DAB staining.

Supplier Data

Western blot - Anti-ISLR antibody (AB232986)

All lanes:

Western blot - Anti-ISLR antibody (ab232986) at 2 µg/mL

All lanes:

Human serum

Secondary

All lanes:

HRP-linked Guinea pig anti-Rabbit at 1/2000 dilution

Predicted band size: 46 kDa

false

Supplier Data

Western blot - Anti-ISLR antibody (AB232986)

All lanes:

Western blot - Anti-ISLR antibody (ab232986) at 2 µg/mL

All lanes:

Recombinant human ISLR protein

Secondary

All lanes:

HRP-Linked Guinea pig Anti-Rabbit Ab at 1/2000 dilution

Predicted band size: 46 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human ISLR.

O14498

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Purification notes

Antigen-specific affinity chromatography followed by Protein A affinity chromatography.

Storage buffer

pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ISLR also known as Immunoglobulin Superfamily Containing Leucine-rich Repeat is a protein found in various tissues. With a mass of approximately 97 kDa this protein functions mechanically through its involvement in cellular adhesion and signal transduction. ISLR is highly expressed in stromal and immune cell types indicating its role in tissue architecture and immune responses. Its structure includes leucine-rich repeats and immunoglobulin-like domains contributing to its role in cell-cell interaction and communication.

Biological function summary

ISLR participates in critical processes such as cell migration and tissue homeostasis. It is a part of specific protein complexes that mediate interaction with extracellular matrix components and modulate signaling pathways important for immune function. ISLR’s involvement in these complexes suggests it contributes to maintaining the balance between cell proliferation and differentiation which is necessary for proper tissue maintenance. Furthermore its expression pattern highlights its influence on stromal-immune system interactions.

Pathways

ISLR integrates itself into the Wnt signaling pathway and TGF-beta signaling which are fundamental for cellular development and homeostasis. ISLR interacts with other proteins such as beta-catenin and SMADs reflecting its regulatory role in these pathways. These associations point towards its involvement in managing cellular responses to external stimuli and ambiance changes important for cell fate decisions and tissue regeneration.

ISLR shows a strong association with cancer progression and fibrosis. Elevated ISLR expression has been observed in tumor microenvironments implicating its role in promoting an environment conducive to cancer cell survival and proliferation. Additionally the interaction between ISLR and TGF-beta-related proteins can enhance fibrotic responses leading to pathological tissue scarring. Understanding these connections helps in unraveling ISLR's contributions to disease mechanisms potentially presenting targets for therapeutic intervention.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

See full target information ISLR

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

International journal of clinical oncology 29:771-779 PubMed38600426

2024

Progressive changes in the protein expression profile of alveolar septa in early-stage lung adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Toru Kimura,Takashi Akazawa,Yu Mizote,Harumi Nakamura,Miki Sakaue,Tomohiro Maniwa,Yasushi Shintani,Keiichiro Honma,Hideaki Tahara,Jiro Okami

Journal of translational medicine 21:817 PubMed37974228

2023

HOXD9/miR-451a/PSMB8 axis is implicated in the regulation of cell proliferation and metastasis via PI3K/AKT signaling pathway in human anaplastic thyroid carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Yong Zhong,Fan Yu,Ling Yang,Yu Wang,Lin Liu,Chengyou Jia,Haidong Cai,Jianshe Yang,Shiyang Sheng,Zhongwei Lv,Li Weng,Bo Wu,Xiaoping Zhang

International journal of molecular medicine 48: PubMed34713300

2021

Silencing of inhibits tumour progression and glycolysis by inactivating the IL‑6/JAK/STAT3 pathway in non‑small cell lung cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Peng Zhang,Zhen Li,Guangming Yang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-ISLR antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ISLR antibody (AB232986)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ISLR antibody (AB232986)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ISLR antibody (AB232986)

Western blot - Anti-ISLR antibody (AB232986)

Western blot - Anti-ISLR antibody (AB232986)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

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