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AB118201

Anti-ISOC2 antibody

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(1 Publication)

Rabbit Polyclonal ISOC2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ISOC2 aa 1 to C-terminus.

View Alternative Names

Isochorismatase domain-containing protein 2, ISOC2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ISOC2 antibody (AB118201)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ISOC2 antibody (AB118201)

ab118201, at 1/100 dilution, staining ISOC2 in formalin-fixed, paraffin-embedded Human fetal liver tissue showing nuclear staining, by Immunohistochemistry.

Western blot - Anti-ISOC2 antibody (AB118201)
  • WB

Unknown

Western blot - Anti-ISOC2 antibody (AB118201)

All lanes:

Western blot - Anti-ISOC2 antibody (ab118201) at 1/500 dilution

Lane 1:

PANC-1 cell

Lane 2:

Human fetal liver lysate

Predicted band size: 22 kDa

Observed band size: 22 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human ISOC2 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q96AB3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Lyophilized
Reconstitution
Reconstitute in 200 µL of water
Purification technique
Affinity purification Immunogen
Purification notes
ab118201 is purified by a protein affinity column.
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The ISOC2 protein also known as Isochorismatase Domain Containing 2 is an enzyme with a molecular mass of approximately 30 kDa. This protein localizes in the cytoplasm and is expressed in several tissues including the liver and kidney. ISOC2 functions as an isochorismatase involved in catalyzing hydrolysis reactions which play roles in diverse cellular processes. The enzyme's distinct domain structure allows it to participate effectively in its mechanical roles within the cell.
Biological function summary

The function of ISOC2 extends to participating in cellular metabolic processes. It often functions within protein complexes that modulate specific biochemical pathways. ISOC2's enzymatic activity links with pathways regulating metabolite flux and cellular homeostasis which is essential for maintaining cellular equilibrium. The enzyme's contribution to these pathways emphasizes its role in stabilizing intracellular environments.

Pathways

ISOC2 interacts with metabolic pathways particularly those involving core physiological metabolites. It shows connections to regulatory pathways such as the cholesterol biosynthesis pathway. In these pathways ISOC2 may interact with other related proteins like HMGCR which plays a major role in cholesterol synthesis. The involvement of ISOC2 in these pathways highlights its importance in maintaining metabolic stability.

ISOC2 links to metabolic syndromes and conditions like hypocholesterolemia and liver dysfunction. These conditions often involve disruptions in metabolic pathways where ISOC2 exerts significant regulatory effects. Additionally ISOC2's activity can connect to HMGCR as disruptions in cholesterol homeostasis can lead to metabolic-related diseases. Understanding the role of ISOC2 in these disorders aids in identifying potential therapeutic targets.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information ISOC2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Haematologica 100:585-94 PubMed25637050

2015

ANGPTL7 regulates the expansion and repopulation of human hematopoietic stem and progenitor cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yiren Xiao,Zhiwu Jiang,Yin Li,Wei Ye,Bei Jia,Minjie Zhang,Yan Xu,Donghai Wu,Liangxue Lai,Yaoyu Chen,Yingjun Chang,Xiaojun Huang,Hudan Liu,Guoliang Qing,Pentao Liu,Yangqiu Li,Bing Xu,Mei Zhong,Yao Yao,Duanqing Pei,Peng Li
View all publications
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Product promise

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