AB198826

Anti-ITGA11 antibody

Name: Anti-ITGA11 antibody. Rabbit polyclonal (ab198826) | Abcam
Brand: Abcam Limited
SKU: AB198826

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(10 Publications)

Rabbit Polyclonal ITGA11 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 10 publications. Immunogen corresponding to Synthetic Peptide within Human ITGA11.

View Alternative Names

MSTP018, ITGA11, Integrin alpha-11

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITGA11 antibody (AB198826)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITGA11 antibody (AB198826)

Immunohistochemical staining of paraffin-embedded human liver cancer tissue labeling ITGA11 using ab198826 at a 1/200 dilution.

Supplier Data

Western blot - Anti-ITGA11 antibody (AB198826)

6% SDS PAGE

All lanes:

Western blot - Anti-ITGA11 antibody (ab198826) at 1/200 dilution

All lanes:

Mouse skeletal muscle tissue lysate at 40 µg

Predicted band size: 133 kDa

Observed band size: 150 kDa

false

Exposure time: 3min

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human ITGA11. The exact immunogen used to generate this antibody is proprietary information.

Q9UKX5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ITGA11 also known as Integrin alpha-11 functions mechanically as an alpha subunit that combines with the beta-1 subunit to form a collagen receptor integrin complex. The protein has a mass of approximately 135 kDa and its expression occurs mainly in fibroblastic cells located within connective tissue including areas like skin and lungs. ITGA11 plays a role in cell adhesion helping mediate interactions between cells and the extracellular matrix which is essential for tissue structure and function.

Biological function summary

ITGA11 influences various cellular processes including cell migration proliferation and differentiation. The protein is part of the alpha-11 beta-1 integrin complex that specifically binds to interstitial collagens. This interaction allows ITGA11 to facilitate communication signals that control cellular behavior. Its effective function in collagen recognition establishes ITGA11 as important for maintaining the structural integrity and repair of tissues particularly during injury or developmental processes.

Pathways

ITGA11 integrates into the collagen-mediated signaling pathway which connects to cellular responses to the extracellular matrix. In particular ITGA11 interacts with other proteins like integrin beta-1 to affect cell survival and movement. Another important pathway involving ITGA11 is the TGF-beta signaling pathway where it contributes to matrix reorganization and fibroblast activation both significant in tissue development and repair mechanisms.

ITGA11 shows association with fibrotic diseases and certain cancers. In fibrosis excessive collagen deposition occurs and ITGA11's interaction with collagen and its regulatory role in fibroblasts can exacerbate this condition. This relationship links ITGA11 to proteins like integrin beta-1 and TGF-beta which are involved in fibrotic tissue transformation. In cancer ITGA11 supports tumor stroma formation contributing to cancer cell survival and spread emphasizing its importance in tumor biology and as a potential therapeutic target.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Integrin alpha-11/beta-1 is a receptor for collagen.

See full target information ITGA11

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Publications (10)

Recent publications for all applications. Explore the full list and refine your search

Molecular medicine reports 31: PubMed39791208

2025

NGR1 reduces neuronal apoptosis through regulation of ITGA11 following subarachnoid hemorrhage.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Hou,Lihan Zhang,Wenzhe Ma,Yong Jiang

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 37:e22946 PubMed37219464

2023

TRPV4 regulates β1 integrin-mediated cell-matrix adhesions and collagen remodeling.

Applications

Unspecified application

Species

Unspecified reactive species

Chenfan Ji,Yongqiang Wang,Qin Wang,Andrew Wang,Aiman Ali,Christopher A McCulloch

Bioengineered 12:11909-11921 PubMed34802381

2021

Inhibition of integrin subunit alpha 11 restrains gastric cancer progression through phosphatidylinositol 3-kinase/Akt pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Haijun Zhang,Lin Zhang,Ming Lu

Frontiers in cell and developmental biology 9:678670 PubMed34504839

2021

Cancer-Associated Fibroblasts Promote Vascular Invasion of Hepatocellular Carcinoma via Downregulating Decorin-integrin β1 Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaobo Zheng,Peng Wang,Li Li,Jing Yu,Chune Yu,Liangliang Xu,Lian Li,Fuzhen Dai,Lei Feng,Hong Zou,Xiaobo Chen,Ming Zhang,Mingqing Xu

Molecular oncology 15:1507-1527 PubMed33682233

2021

Cancer-associated fibroblast migration in non-small cell lung cancers is modulated by increased integrin α11 expression.

Applications

Unspecified application

Species

Unspecified reactive species

Moe Iwai,Miniwan Tulafu,Shinsaku Togo,Hideya Kawaji,Kotaro Kadoya,Yukiko Namba,Jin Jin,Junko Watanabe,Takahiro Okabe,Moulid Hidayat,Issei Sumiyoshi,Masayoshi Itoh,Yu Koyama,Yasuhiko Ito,Akira Orimo,Kazuya Takamochi,Shiaki Oh,Kenji Suzuki,Yoshihide Hayashizaki,Koji Yoshida,Kazuhisa Takahashi

International journal of oncology 57:1333-1347 PubMed33174014

2020

Long non‑coding RNA FEZF1‑AS1 facilitates non‑small cell lung cancer progression via the ITGA11/miR‑516b‑5p axis.

Applications

Unspecified application

Species

Unspecified reactive species

Heng Song,Hui Li,Xiaosong Ding,Minglei Li,Haitao Shen,Yuehong Li,Xianghong Zhang,Lingxiao Xing

Journal of cellular and molecular medicine 24:11814-11827 PubMed32885592

2020

Comparative proteomic analysis of osteogenic differentiated human adipose tissue and bone marrow-derived stromal cells.

Applications

Unspecified application

Species

Unspecified reactive species

Mehran Dadras,Caroline May,Johannes Maximilian Wagner,Christoph Wallner,Mustafa Becerikli,Stephanie Dittfeld,Bettina Serschnitzki,Lukas Schilde,Annika Guntermann,Christina Sengstock,Manfred Köller,Dominik Seybold,Jan Geßmann,Thomas Armin Schildhauer,Marcus Lehnhardt,Katrin Marcus,Björn Behr

OncoTargets and therapy 13:5323-5335 PubMed32606750

2020

Connexin 43 Modulates the Cellular Resistance to Paclitaxel via Targeting β-Tubulin in Triple-Negative Breast Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yun Fu,Xiaoyin Sun,Zhangyuan Gu,Zhigang Zhuang

eLife 8: PubMed30632962

2019

Integrin alpha11 is an Osteolectin receptor and is required for the maintenance of adult skeletal bone mass.

Applications

Unspecified application

Species

Unspecified reactive species

Bo Shen,Kristy Vardy,Payton Hughes,Alpaslan Tasdogan,Zhiyu Zhao,Rui Yue,Genevieve M Crane,Sean J Morrison

Journal of cellular physiology 233:8884-8895 PubMed29851084

2018

Elevated transforming growth factor β signaling activation in β-actin-knockout mouse embryonic fibroblasts enhances myofibroblast features.

Applications

Unspecified application

Species

Unspecified reactive species

Xin Xie,Piergiorgio Percipalle

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-ITGA11 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITGA11 antibody (AB198826)

Western blot - Anti-ITGA11 antibody (AB198826)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (10)

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